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Introduction: Androgenetic alopecia is a very common disease. According to some reports, up to 96% of people have some form of this disease. In this paper we compared the effect of an herbal drug composed of the urticadioica, chamomilla, thymus vulgaris, equisetum arvense and foeniculum vulgare with 2% Minoxidil solution in the treatment of androgenetic alopecia.
Materials and Methods: We evaluated 82 patients suffering from androgenetic alopecia in a double blind prospective study. We counted terminal and vellous hair in 1 square centimeter of the predetermined area of scalp before and after treatment. After 6 months of treatment, the results were evaluated
Results: According to our findings, herbal drug and Minoxidil were effective in regrowthing the hair (45% vs. 35% respectively) and there were no meaningful differences between efficiacies of these two drugs
Conclusion: Herbal drug can be used as an adjunct or as an alternative to Minoxidil for treatment of the androgenetic alopecia.

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Background: The emergence of antibiotic resistance, particularly resistance to methicillin in Staphylococcus aureus has made the treatment process more difficult. Therefore, producing of an effective vaccine seems to be necessary to prevent infections with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a mixture of naloxone and alum has been used to improve the efficacy of a vaccine against MRSA.

Materials and Methods: MRSA 834 strain was grown on TSB medium and the grown cells were harvested and killed by sonication and were used as a vaccine model. Balb/c mice were divided into six groups and the vaccines were either injected alone, with naloxone, alum, or a mixture of naloxone - alum and control group received naloxone and PBS buffer. Total IgG antibody level was measured by ELISA method and finally, the challenge test of this bacterium was performed and the mice were examined regarding the degree of bacteria growth in their kidneys.

Results: The serum level of Total IgG antibody in the mixture of naloxone – alum with MRSA group was shown to be significantly increased (p<0.05). Furthermore, the lowest bacterial load was observed in this group.

Conclusion: It seems that a mixture of naloxone and alum as an adjuvant with the killed methicillin-resistant Staphylococcus aureus enhances the humoral immunity leading to a high level of protection against MRSA infections. Therefore, this seems to be a good option for improving the performance of this vaccine.