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Showing 3 results for Hooshmandi
Biochemical Evaluation of the Effects of Iranian Snake (Naja Naja Oxiana) Venom According to the Kidney Indices in Rabbit
Abbas Zaree Mirakabadi, Abdolhamid Angaji, Adele Hooshmandi,
Volume 17, Issue 2 (5-2014)
Abstract

Background: One of the acute effects of snakebite is injury to vital organs including kidneys. This study examines the effects of snake (Najanajaoxiana) venom on renal function.

Materials and Methods: In this experimental study, six male Dutch rabbits with average weight of 1.5± 0.3 kg were selected. Before injection of the venom, blood samples were collected for serum analysis and then the snake (Najanajaoxiana) venom (140µg/kg) was injected intramuscularly. Following venom injection, blood sampling from each rabbit was carried out at hours 1, 3, and 24. All serum samples were separated within two hours and the amounts of creatinine, urea, albumin, and glucose were determined by quantitative detection kits. Statistical analyses were carried out by SPSS software version 21. Obtained information was compared by one-way ANOVA and F and Tukey tests. p value<0.05 was considered significant.

Results: Following venom injection at hours 1, 3, and 24, some serum parameters showed slight changes which were not statistically significant. However, glucose showed a significant increase (71%) at hour 1 (p<0.05). Following venom injection, this returned to normal at hour 24.

Conclusion: Based on the results obtained in the present study, it seems that the Najanajaoxiana venom, unlike the viper species, have no severe effects on the kidney.


The Role of Hippocampal Orexin-1 Receptors (OX1R) in Mediating the Effect of Morphine on CA1 Baseline Synaptic Response and Short Term Synaptic Plasticity
Mehdi Hooshmandi, Narges Hosseinmardi, Mahyar Janahmadi, Fereshteh Motamedi, Azadeh Elahi Mahani, Fatemeh Sadat Aghamiri,
Volume 17, Issue 6 (9-2014)
Abstract

Background: Considering the increased activity of hypothalamic orexinergic neurons due to morphine administration, and its extensive projections to the hippocampus, it is probable that morphine effect on CA1 neuronal function is mediated by orexinergic system. So the effect of hippocampal orexin-1 receptors (OX1R) blockade on CA1 baseline synaptic response and short term synaptic plasticity was investigated.

Materials and Methods: In this experimental study, animals received morphine 10 mg/kg/12h/(SC) for 10 days. SB-334867-A, OX1R antagonist (0.5&mug/0.5 &mul), was microinjected intrahippcampally for OX1R inhibition before each morphine injection. Baseline synaptic response and short term synaptic plasticity were evaluated by field potential recording. fEPSP was recorded from CA1 following Schaffer collaterals stimulation. After Input/Output construction, short term synaptic plasticity was induced by paired pulse stimulations.

Results: Chronic use of morphine did not affect the baseline synaptic response (p>0.05). SB- 334867-A microinjection in CA1 did not have any effect on baseline synaptic response in morphine dependent rats. Morphine increased paired pulse index (PPI) at 80 ms inter pulse interval (IPI, p<0.05). SB-334867-A pretreatment did not affect this morphine induced PPI change.

Conclusion: The results suggest that orexin-1 receptors (OX1R) do not mediate the effect of morphine on baseline synaptic response and short term synaptic plasticity in CA1 area of the hippocampus.


Examining the Prevalence of Hypothyroidism in Pregnant Women with Fetal Echogenic Foci Referred to Amir Al-Momenin Hospital in Semnan from September 2022 to September 2023
Mohammad Javad Gouran, Soodeh Hooshmandi, Sajjad Rahimi Pordanjani,
Volume 28, Issue 3 (8-2025)
Abstract
Introduction: An echogenic intracardiac focus (EIF) is one of the most common non-structural findings on fetal ultrasound, typically detected between 18 and 20 weeks of gestation. EIF is often considered a soft marker in prenatal screening. However, its association with maternal risk factors—particularly endocrine disorders such as hypothyroidism—remains unclear. This study aimed to evaluate the prevalence of hypothyroidism in pregnant women carrying fetuses with EIF and to investigate its correlation with other clinical variables.
Methods: In this cross-sectional study conducted from September 2022 to September 2023 at Amir-al-Momenin Hospital in Semnan, Iran, 100 pregnant women with fetuses diagnosed with EIF confirmed by fetal echocardiography were evaluated. Maternal demographic data, medical history, and fetal sex were collected and statistically analyzed.
Results: The mean maternal age was 41.55 ± 4.0 years, and the mean gestational age was 21.4 ± 3.65 weeks. Hypothyroidism was observed in 7% of the mothers and showed a statistically significant association with the presence of fetal EIF (P = 0.00). Furthermore, hypothyroidism was also significantly associated with underlying maternal diseases and fetal sex. However, no significant association was found between hypothyroidism and maternal age or gestational age.
Conclusions: The findings indicate a noteworthy prevalence of hypothyroidism among pregnant women carrying fetuses with EIF. These results highlight the importance of evaluating maternal thyroid function during pregnancy, particularly in cases where EIF is detected. Further research is recommended to clarify the underlying mechanisms and potential outcomes of this association.
 
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