Journal of Arak University of Medical Sciences

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Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats

Javad Sohrabi Asadabad, Zohreh Ghotbeddin, Mohammad Reza Tabandeh,
Volume 20, Issue 9 (12-2017)

Abstract

Abstract
Background: A lot of studies indicate that cancer chemotherapy drugs such as doxorubicin results in memory impairment. On the other hand, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor enhancement. So, in this work, we have studied the co-administration effect of crocin and doxorubicin on avoidance memory and motor activity in adult male rat.
Material and Methods: In this study, 50 male rats were divided into 5 groups: control, sham, doxorubicin, crocin and treated rats with coadministration of doxorubicin and crocin. In crocin group, crocin injected 30mg/kg for 21 days and each rat in the chemotherapy group was treated once a week for 3 weeks with doxorubicin (5mg/kg). Treatment group, received doxorubicin and crocin at the same time. Sham groups administrated with saline. All drugs were injected intraperitoneally. After these procure passive avoidance memory, balance and exploratory behaviors were assessed respectively by shuttle box, rotarod and open field instruments.
Results: Memory in rats which have consumed doxorubicin significantly was decreased compared to other groups (p<0.001). Crocin treatment improved memory impairment following doxorubicin injection (p<0.001). Motor activity in open field and rotarod tests in treatment group showed significantly increased compared to doxorubicin group (p<0.001).
Conclusion: Crocin consumption beside of anticancer drugs such as doxorubicin has protective effect on the bad effects of chemotherapy drugs on memory and movement.

Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety-Like Behavior in Adult Male Rat

Raha Zalkhani, Ahmad Ali Moazedi, Zohreh Ghotbeddin, Mahdi Pourmahdi Borujeni,
Volume 21, Issue 4 (8-2018)

Abstract

Background and Aim: Emotional disorders are prevalent in many epileptic patients. So, in this research, we have studied the efficacy of two treatment methods of seizure on anxiety-like behavior during kindling in adult male rat.
Materials and Methods: 42 male rats were randomly divided into 6 groups: Control, Sham operation, saline-kindled and drug-kindled groups which have received saline or drug 15 minutes before kindling stimulations, and saline-kindled-LFS or drug-kindled-LFS group which have received saline or drug 15 minutes before kindling stimulations and LFS applied after termination of kindling stimulations. Anxiety-like behavior was assessed on the 6th day by using elevated plus maze and open field apparatus.
Findings: kindling significantly increased open arms (OAs) entries percentage, OAs exploration percentage, increasing jumping from elevated plus maze (p<0.001) and rearing frequency in open field apparatus (p<0.05) compared to the sham group. Sodium valproate increased OAs entries percentage and OAs exploration percentage in drug-kindled group compared to sham group (p<0.001). But, there wasn’t any significant difference in jumping from elevated plus maze and rearing in open field compared to sham group. Also, there was no significant change in these parameters in Saline-kindled-LFS, drug-kindled and drug–kindled-LFS groups.
Conclusion: Sodium valproate and LFS, as two therapies controlling epilepsy, decrease anxiety induced by kindling stimulation.

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