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Showing 3 results for Ghodraty
Comparing the Effects of Sedation Induced by Fentanyl and Remifentanil in Patients Under Mechanical Ventilation
Mohammad Reza Ghodraty, Alireza Pournajafian, Mohammad Niakan, Mohammad Zia Totonchi Ghorbani, Fatemeh Sadat Mazhari,
Volume 18, Issue 10 (1-2016)
Abstract

Background: Reducing the duration of the effect of sedatives and increasing their quality is one of the tasks of ICU staff. The aim of this study is to compare the sedative effects of these medications on neurosurgery patients under mechanical ventilation.

Materials and Methods: In this double-blind clinical trial, 70 patients requiring mechanical ventilation in neurosurgery ICU were enrolled. Patients were randomly assigned to one of remifentanil or fentanyl groups. The first group received 0.05 µg/kg/min remifentanil and the second group received 1 µg/kg/hr fentanyl infusion for sedation and analgesia in the first 24 hours. Sedation score, Minogue scale and hemodynamic parameters were evaluated throughout the study and at regular intervals. 

Results: There was no significant statistical difference in demographic variables such as age, sex, and body weight between two groups. The results of this study showed a significant difference in sedation score (p=0.0001) and Minogue scale (p=0.0001) and both variables were lower in remifentanil group. Also, heart rate (p=0.011) and mean arterial blood pressure (p=0.007) were significantly higher in fentanyl group.

Conclusion: Generally, sedative effect of remifentanil has several relative advantages over older medication of fentanyl and causes more effective sedation and better control of hemodynamic parameters in patients under mechanical ventilation.


Comparison of Anesthetic Depth and Its Relationship with Hemodynamic Changes in Patients Candidate for Total Abdominal Hysterectomy Under General Anesthesia with Propofol or Isofluran Using Bispectral Index
Alireza Kholdebarin, Faranak Rokhtabnak, Mohammadreza Ghodraty, Alireza Pournajafian,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: Hemodynamic changes during surgery are initially controlled by changes in dosage of anesthetics. Decreasing the dose of anesthetics in order to cope with hypotension during surgery may reduce the anesthetic depth and increases the chance of awareness. This study was designed to investigate the depth of anesthesia in patients whose anesthtics is prescribed by controlling blood pressure and is aimed to investigate the possibility of reducing the depth of anesthesia during surgery.
Materials and Methods: In this study, females candidate for hysterectomy underwent general anesthesia according to specific inclusion criteria enrolled in two types of intravenous (propofol) or inhaled (isoflurane) anesthesia. The dose of maintenance anesthetic drugs were increased or decreased during the operation by the anesthetist technician (blinded to the depth of anesthesia) according to specified protocol. At defined intervals, depth of anesthesia was recorded by the anesthetist . Mean of obtained data were analyzed.
Results: In addition to the weight and height similarity, there was no statistically significant difference in systolic, diastolic blood pressure and heart rate in two groups at intervals, between two groups. The median of recorded BIS, which showed depth of anesthesia, was not different in either of the two groups, and no patients during the operation reached the level of awakening and the number above 60.
Conclusion: The traditional method to control hemodynamic changes during surgery by changing the doses of maintenance drugs, does not result in severe changes in the depth of anesthesia and does not significantly increase the BIS to the awareness level.
 

A Comparative Study on the Effectiveness and Onset of Action of Ondansetron and Meperidine in Post-Anesthesia Shivering Treatment
Mohammadreza Ghodraty, Faranak Rokhtabnak, Alireza Kholdebarin, Alireza Pournajafian,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: Postoperative shivering is a common complication after recovering from anesthesia, and due to its subsequent side effects, its prevention and treatment is of special importance for anesthetists. In this study, the efficacy and onset of action of meperidine (which is a potential cause of hemodynamic and respiratory complications) in treatment of post-anesthesia shivering are compared with those of ondansetron.
Methods & Materials: In this clinical trial study, patients with post-anesthetic shivering during recovery were randomly divided into two groups of meperidine (n=27) and ondansetron (n=29). Their shivering scores were recorded every minute for up to 10 minutes. After this time, if patients did not improve, meperidine was used in both groups to treat shivering.
Ethical Considerations The study obtained its ethical approval from the Research Ethics Committee of Iran University of Medical Sciences and has been registered in Iranian Registry of Clinical Trials (IRCT201109224969N3).
Results: The number of patients completely treated at 10 minutes was higher in the meperidine group (P= 0.05), and the decrease in mean shivering score occurred faster in meperidine group (P= 0.047)
Conclusion: Although ondansetron has been shown to be effective in treatment of postoperative shivering, the effectiveness and onset of action of meperidine was clearly better.

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