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Introduction: Neisseria  gonorrhoeae  is  a  gram  negative  diplococci  belong  to  family  neisseriacae  and  is  causative  agent  of  gonorrheae.  Culture  and  antibiograme  of  this  bacteria  is  done  lower  than  other  cases  and  determination  rate  of  MIC  in  this  bacteria  is  inly  done  in  reference  laboratories.  The  goal  of  this  study  id  introducing  a  relationship  which  in  studied  population, MIc  more  easily  and  eithout  doing  complex  technical  examinations  is  placed  available  for  physicians.
Materials  and  Methods: In  this  research  on  50  cases  of  Neisseria  gonorrhoeae  isolated  from  patients  with  gonorrhoeae  antibiograme  test  were  done  and  then  for  every  antibiotic  discs  the  zone  of  inhibition  were  measured.  Then  on  the  basis  of  instructions  of  NCCL  for  four  antibiotics  were  planed  to  this  disease (penicillin, tetracycline, spectinomycine  and  ceftriaxone) MIc  on  GC  agar  medium  were  measured  and  between  zone  of  inhibition  as  an  independent  variable  and  MIC  as  a  dependent  variable  linear  regression  is  seen  which  from  this  line  equation  can  understand  how  is  the  relation  between  MIc  and  zone  of  inhibition. It  means  that  wether  this  relationship  is  direct  or  reverse?
Results: The  findings  show  that  in  all  antibiotics  the  relationship  between  zone  of  inhibition  and  MIc  are  negative (reverse)  and  regression  coefient  for  first  three  antibiotics  have  (p<0.0001)  and  for  fourth  antibiotics  has  (p<0.001).
Conclusions: It  means  that  with  probability  less  than  0.0001  for  penicillin, tetracycline, spectinomycine  and  probanility  less  than  0.001  for  ceftriaxone  can  estimate  the  counter  effect  pf  zone  of  inhibition  and  MIc  in  studied  population.
 

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Introduction: Insulin-dependent diabetes mellitus (IDDM) or type 1 diabetes is an organ-specific autoimmune disease that caused by destruction of insulin-producing beta cells of the pancreas. Etiology of this disease is still unknown. It is seen that genetic and environmental factors play an important role for susceptibility to develop type 1 diabetes. The relationship between HLA associated factors and susceptibility to IDDM disease, was reported by several investigators. Also, some studies show that dermatoglyphics is associated with type 1 diabetes. However, it is maybe there is an association between HLA and dermatoglyphics inpatients'with type 1 diabetes and these characteristics could be applied for diagnosis of disease.
Materials and Methods: In this study, the prevalence of HLA (with using standard microlymphocytotoxicity method) and dermatoglyphics determined in 30 Iranian patients with IDDM and 30 normal healthy controls with similar ethnic background and the same geographical area.
Results: A significantly higher frequency of HLA-DQ, A2, DR3 and DQ2 were found in IDDM cases compared to the controls. The results obtain from dermatoglyphics showed that line ab was reduced in male and female type 1 diabetes. The reciever operating chractristics curve showed that the positive point for lines ab in right and left hands were 34.7 and 35.25, respectively.
Discussion: There is no association between HLA and dermatoglyphics.
With considering of genes encoding of HLA separated from genes determining dermatoglyphics, HLA typing and dermatoglyphics seem to be interesting tools for genetic studies related to type 1 diabetes. Further studies are recommended in order to provide more insight into the susceptibility to this disorder.

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Background: Brucellosis is one of the most important diseases among humans and animals. Clinical management of brucellosis due to an increased rate of treatment failure and recurrence is extremely worrying. The aim of this study was to determine the antimicrobial susceptibility pattern of the brucella isolates.

Materials and Methods: From April to September 2014 a total of 30 brucella isolates that were cultured on brucella agar has been studied. The species identification was carried out and to determine the effect of antibiotics on bacteria antibiogram testing was performed by disk diffusion.

Results: In this study, 30 brucella strains were isolated from cultured specimens and antibiogram testing was performed. All microbial positive specimens were sequenced by PCR. All isolates were Brucella melitensis. According to the tests, suceptibility to tetracycline, minocycline, gentamicin, tigecyclin was 100%, to doxycycline 93.3%, co-amoxiclave 66.7%, rifampin 44.7%, streptomycin 86.7%, ciprofloxacin 80%, cotrimoxazole 76.7% and ceftriaxone 73.3%.

Conclusion: This study shows that the predominant strain in our patients was Brucella melitensis. Also, due to high levels of resistance to rifampin to use the other effective drugs like gentamicin, streptomycin, ciprofloxacin or cotrimoxazole in combination with doxycycline or tetracycline.