Journal of Arak University of Medical Sciences

Search published articles

Showing 2 results for Ghatreh Samani

Study of Relationship of Activation and -107 C/T Polymorphism in Paraoxonase 1 Gene with Fatty Acid Diversity in Phospholipids of High Density Lipoprotein

Keyhan Ghatreh Samani, Effat Farrokhi, Morteza Hashemzadeh, Esfandyar Heidarian,
Volume 16, Issue 5 (8-2013)

Abstract

Background: Paraoxonase1 activity shows decline in patients with coronary artery disease. The C to T change in the -107 position of promoter is the most important genetic determinant of serum levels of paraoxonase 1. Study of this polymorphism and its relationship with the type of fatty acid composition of phospholipids in HDL particles can be found in the common pursuit of better medicines and considered in drug treatment.

Materials and Methods: In this descriptive study 265 Patients were selected and divided in two groups based on LDL level (131 in case and 134 in control). Information of subjects were collected from questionnaire and the results of biochemistry and molecular tests. Fatty acids of HDL phospholipids were measured with Gas chromatography technic .

Results: PON1aryl esterase activity, had no significant changes after treatment with lovastatin but paraoxonase activity had more significant increases in the CC genitype of -C/T107 polymorphism. Percent of oleic acid, linoleic acid and icosapentanioc acid in HDL phospholipids were increased by lovastatin.

Conclusion: Treatment with lovastatin in the CC genotype is probably more protective effect against cardiovascular disease. Following treatment, in patients with higher paraoxanase 1 activity Oleic acid and linoleic acid have also increased in HDL phospholipids.

Transvaginal Ultrasound Compared with Serum β-hCG Level for Diagnosis of Ectopic Pregnancy in Symptomatic Patients

Fatemeh Ghatreh Samani, Ali Nourian, Laya Farzadi,
Volume 20, Issue 10 (1-2018)

Abstract

Abstract
Background: Ultrasonography (US) is the most important imaging modality in detecting both intrauterine and ectopic pregnancies. This study aimed to compare serum β-hCG level with Transvaginal Ultrasound in symptomatic patients with ectopic pregnancy.
Materials and Methods: A total of 210 patients with definite diagnosis of ectopic pregnancy were enrolled prospectively. All patients underwent transvaginal US by an experienced radiologist who was blind to the final status of the patient. Serum levels of β-hCG and the time gap between US examination and last menstrual period (LMP) were compared between patients with positive and negative US findings.
Results: US were positive in 194 patients (92.4%) and negative in the remaining 16 patients (7.6%). The two groups were similar in terms of age (median, 31 years vs. 30.5 years, respectively; p=0.57). Both the median time gap between US and LMP (median, 43 days vs. 34 days, p=0.03) and serum level of β-hCG (median, 1027 mIU/ml vs. 172.5 mIU/ml, p<0.001) were significantly higher in patients with positive US findings. Both differences were independent of each other in multivariate analysis. The best discriminative zone was set at a serum β-hCG level of 326 mIU/ml with a sensitivity and specificity of 86.6% and 87.5%, respectively.
Conclusion: According to our findings, both the median serum level of β-hCG and time gap between US and LMP in patients with missed diagnosis of ectopic pregnancy were significantly lower in comparison with correct diagnosis and proposed discriminative zone for serum level of β-hCG in our study is different from the previous studies though further studies are recommended especially in symptomatic patients with suspected ectopic pregnancy.

Page 1 from 1

Designed & Developed by : Yektaweb