Akram Ranjbar, Hajar Rajabian, Yhya Jand, Elahe Mirza Zadeh, Akram Esmaili , Sara Ghasemi Nejad , Ali Akbar Malekirad,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: Disturbance between production of free radicals and antioxidant defense is named oxidative stress. One of the main sources of free radicals is smoking that induce oxidative stress.
Materials and Methods: This is a cross sectional study in which questionnaires including information such as age, sex, education, history and number of smoking and history of special disease were filled. Case group were smokers (n=43) who were smoking at least 5 years and their mean age was 37.7 year. The control group was consisted of 43 nonsmokers which were matched for age and sex. They were evaluated for oxidative stress markers including thiobarbituric acid reactive substance (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total thiol (SH) groups and gammaglutamyl transferase (GGT) levels in blood.
Results: Results showed that induction of oxidative stress in smokers as revealed by decreased FRAP (1.89±0.03 vs 2.24±0.04, p=0.01) and plasma Sh groups (0.22±0.08 vs 0.81±0.48, p=0.01) in comparison to those of controls. The activity of GGT and level of LPO increased but were not significant . Also the correlation between history of smoking and oxidative stress was not significant.
Conclusion: It is concluded that smoking have decreased FRAP and SH groups which may put smokers at future consequences of oxidative stress. It seems that improving antioxidant system in smokers is effective.
