Showing 22 results for Fani
Ali Fani, Abbasali Mehrabian, Oskouei, Davari,
Volume 1, Issue 3 (Summer 1997)
Abstract
Ali Fani,
Volume 2, Issue 8 (Autumn 1999)
Abstract
In this survey CRF case from Arak , Shazand and Ashtiyan (769000 population), who have referred to Vali-e Asr general hospital and each case has been observed individually. During two years ( From 22 may 1997 until 21 may 1999), it showed that, 127 CRF patients there were 59 females (44.1%) and 71 males (55.9%). The annual rate was 82.3 per million, 21.25% were rural and 78.75% were urban while the rate of rural population to urban population is 44% to 66%. It seems as is the lower rate of rural patients is due to socioeconomic problems and lack of study, recognition and poor control of diseases, especially in higher ages and it doesn’t necessarily meaning lower rate of this illness in villages. In this survey, the highest rate is seen in glumerolonephritis and then in hypertension and diabetes mellitus which this trend is quite opposite in western societies. The reason probably is the socioeconomic problems as well as lack of patients familiarity with this diseases and the significance of its regular follow up and treatment and using the special treatment exclusively in villages. Also this survey showed that congenital renal disease and obstructive uropathy diseases are calssified in fourth grade of significance from a CRF etiology. This study showed that although the CRF is more popular in men than women. There is no meaningful difference between them.
Ali Fani,
Volume 3, Issue 1 (Spring 2000)
Abstract
A 56 years old female was admitted to our hospital, because of, dyspnea, tachycardia hematemesis and melena. In physical exams she was severely ill, pale, and tachycardia, with decreased breath sounds on the base of right lung, with BP, 100.60, and pulse rate of 120/min. Abdomen was soft In rectal exam streaky fresh blood and melena was observed. Diffuse red populace on face, trunk and oral mucosa were present with recurrent nasal bleeding since last year. In upper GI endoscopy and colonoscopy, diffuse telangectasic lesions in esophagus, stomach, duodenum and entire length of colon and streaky fresh blood in colon were observed, Under conservative treatment her bleeding stopped on the 10th day after treatment. Collagen vascular diseases, coagulopathy and malignancies were ruled out by paraclinical examinations. Senile angiodisplastic diseases which are usually limited to colon and vascular ectasia can not be suggested because the skin and upper gastrointestinal tract is involved. Cancers, polyps and hemorrhoid , were ruled out by endoscopy and colonoscopy. Heriditary Hemorrhagic Telangictasia (HHT) is an Auto-Dom disorder with involvement of oral and gastrointestinal mucosa, skin and viscera. HHT involves capillaries, makes tortuous, fragile bloody spaces which can be manifested through infancy to old age. The most common manifestation of the diseases(in addition to nose bleeding and skin lesions), is the severe gastrointestinal bleeding, often leading to massive blood transfusion. Recommended treatment:
1-Coagulotherapy of hemorrhagic lesions. 2- Estrogen and progesterone therapy. 3- Amino caproic acid therapy for prevention of fibrinolysis. 4- In severe cases , surgical therapy is needed.
Ali Fani,
Volume 3, Issue 2 (Summer 2000)
Abstract
A brief history and the result: Mr V.M> who died at age of 63 because of cardiac attack and his wife doesn’t mention any symptoms of pheo such az hypertension , catecholamine release and so on. From the 7 girls, one died at age of 18 because of hypertension crisis and CVA. The second girl died during bilateral adrenalectomy .Three of them had extension to inferior vena cava. One boy died at age of 12 with clinical signs and symptoms of pheo. The second boy at age of 27 was healthy with no sign and symptom. All of the family were checked for MEN2 and no one had positive finding. On the basis of history, clinical and paraclinical results, it seems that they have familiar bilateral autosomal dominant pheo with high peneterance. The 24hrs urine collection for measuring VMA and free catecholamines was recommended for each patient. Two positive results of three tests are highly sensitive and suggestive to pheo diagnosis. We can use MIBG.1131, tolemerase En.s which is only secreted by tumoral cell as a specific tool for evalution of malignancy. Although pheo is considered as 0.1% of etiology of hypertension, it is a curable cause. Any young patient with labile hypertension, anxiety, palpitation, seating, weight loss must be considered and worked up for pheo.
Ali Fani,
Volume 3, Issue 3 (Autumn 2000)
Abstract
Acute renal failure (ARF) is common complication in ICU patients(Patients), which causes disturbance of homostasis of, electrolytes, acid-base balance with high mortality Rate, The principle cause of ARF especially in ICU ward are hypotension and Renal hypoperfusion and sepsis complications. This survey was performed with history taking, clinical and Paraclinical evaluation on 952 ICU patients from 21 Jan 1997 to 22 AGu 1999 Vali-Asr Hospital of Arak. From these pts 203 had different degree of ARF, 362 patients were female, 590 male, 5 patients had/chronic renal failure which omitted from study. From 198 patients with ARF 77 (38.9%) were female and 121 (61.1%) were male. Prevalence of ARF in male was 20.6% and in female was 21.4% sex difference is meaningless. The rate of ARF N in this study was 20.9% which there is no meaningful difference with report of western country (20-30). 110(55.5%) patients with ARF were being treated with one aminoglycoside and 66(33.3%) patients were taken aminoglycoside and cephalosporins concomitant compar 40(4.2%) patients with normal renal function. It seems that such nephrotoxic. Total mortality rate in ICU patients was 30.8% and in patients with ARF 116(50.6%) with meaningful difference with PV<0.0001, so ARf intensified most olity rate in ICU patients.
Ali Fani,
Volume 4, Issue 4 (Winter 2001)
Abstract
Introduction: Graves disease is the most prevalent form of thyroxicosis (60-80%), which is caused by an autoimmune reaction. Treating with antithyroid drugs usually lead to prolonged remission in 30%-40% of cases. Paradoxically it is assumed that adding thyroid hormones to the therapy would give more bebefits because of preventing the feedback of TSh to further stimulate the thyroid gland after using antithyroid drug. In this study we compared the effect of adding levothyroxine to the routine therapy in reducing the relapse of thyrotoxicosis.
Material and Method: This was a clinical-trial study in which we compared the two regimens of metimazole plus levothrixine (regimen A), with metimazole alone(regima B), in reducing the graves diseases relapses.
Results: In this 7 years study, 262 patients finished the trial. 137 were assign as group A and 125 cases were assigned to group B. randomely. Graves was most prevalent in 3rd to 5th decades. 52.3% of disease had grade II Goiter. The rate of relapse was 36.4% in group A and 61.6% in group B. during 3 years after discontinuation of therapy.
Conclusion: The peak age of prevalence was found out to be lower than eastern reports (3-5 in comparison to 5-6 decades). Clinical manifestations was not significantly different from other studies. The two regimen results were compared by Or method and calculating Or, in grade I goiter was 0.27 and in grade II was 0.29, grade III was 0.32, which has a meaningful difference and implies regimen A is effective in reducing the prolonged rate of relapse but in garde Iv goiter, there is not significant difference in relapsing in two group.
Ali Fani,
Volume 5, Issue 1 (Spring 2002)
Abstract
Introduction: Inflammatory bowel diseases (IBD), including crohns disease (CD) and ulcerative colitis (UC), belong to the group of inflammatory disease with unknown origin, which primarily involve the gastrointestinal tract but also have extraintestinal manifestations. In western studies, an annual incidence of 5-11 in a hundred is thousands estimated and no similar epidemiological studies have been performed so far in Iran. In this study our goal is to determine the pattern of IBD and its clinical aspects in Arak.
Materials and Methods: In this study of 20 months duration (from april 2000 to sep 2001), all the patients with suspected IBD, referred to specific clinics, were evaluated by careful clinical, paraclinical, colonoscopy and histopathological tests and finally the diagnosis of IBD was made according to these criteria and then the collected data was statistically analyzed.
Results: From the total number of 108 patients , diagnosed with IBD, 97 cases (89.8%) had UC and (10.2%) had CD. From the patients with Uc, 41 (47.4%) were female and 21 (52.6%) were male and in CD patients, 8 cases (72.7%) were female and 27.3% male. 58.8% of UC cases were under 40 yars of age , in 19 cases (19.6%) of patients with UC. The duration of the disease was less than a year. Rectal involvement existed in all the patients with UC. Extraintestinal manifestations were rare except anemia. Patients with CD were all under 30 years old and ileocecal involvement existed in 8 of them with major manifestations of malabsorption syndromes. Recurrent fistulas led to 2 deaths.
Conclusion: Although this is not a broad epidemiological study, our effort eas to detect the maximum number of patients with IBD and in regard with 19 cases with less than a year history of the disease. The annual incidence. Of IBD in Arak is estimated to be more than 3.04% in hundred thousand. In the UC from of IBD. less complications (cancer, stenosis and tioxic colon) were found in comparison to western studies and in the case of CD, the prevalence is much lower but is accompanied by more serious GI complications. it is likely that IBD is no less prevalent in this region than the west but it is more missed and undetected which can be resolved by better evaluation of the patients upon admission.
Ali Fani,
Volume 5, Issue 2 (Summer 2002)
Abstract
Introduction: Lower gastrointestinal bleeding (GIB) as well as upper GIB, is one of the most common causes of patients referral to surgen and internist. From patients view, nothing is as terrible as bleeding from mouth or anus. Lower GIB may be benign or malignant, simple or complex. Bleeding may be occult with further weakness, or it may be severe and lead to death. So lower GIB work up from etiological point of view is mandatory.
Materials and Methods: This was an observational and descriptive-analytic study, performed from Jul, 23, 2000 to Aug,11, 2001. In this study, we evaluated patients with gross rectorrhagia referred to aspecial clinics, by history taking, physical examination, anoscopy, rectosigmoidoscopy, colonoscopy and barium enema.
Results: From the total number of 580 cases who completed the study, 55.0% were male and 44.8% female . 401/3% had constipation and rectorrhagia, 14.7% had chronic diarrhea with rectorrhagia and 45% had rectorrhagia with normal bowel habits. From etiological point of view , 20% of patients had hemorrhoid , 12.4% had anal fissures, 10.2% had inflammatory bowel disease (IBD), 9.65% had polyps, 3.1% had infective pocititis and 30.4% were unknown causes.
Conclusion: Gross rectorrhagia is relatively common cause of GIB. Although most of the lesions were of benign nature. in this study, because of serious complications and high morbidity and mortality, IBD, colonic polyps and cancer must be ruled out with complete work up.
Ali Fani,
Volume 5, Issue 3 (Autumn 2002)
Abstract
Introduction: During the history of internal medicine Goiter has always been at the center of attention as one of the most important endemic disorders. It is estimated that about one billion people around the globe are affected with Goiter. Iran is recognized as an cndemic area for Goiter. The aim of this study was to reveal the pattern of distribution of different thyroid disorders in-patients with Goiter in Markazi Province.
Material and methods: It was a descriptive-cross-sectional study that enrolled 2138 patients with Goiter who were selected randomly and by categorized sampling (F=1542, M=596) TSH serum titers were checked for screening and if abnormal, detailed thyroid function tests were done. We used Radon ELISA Kits previously checked with RIA in our study. Patients were first examined for Goiter and graded if Goiter was found, and if it was nodular, the patient was referred for sonography, thyroid scan and FNA. Then the patients were further evaluated based on clinical findings and laboratory results for various thyroid disorders.
Results: In this study we evaluated 2138 pts with Goiter (72% (1542)=F, 28% (596)=M) from which 83.1% had a simple Goiter, 6.94% were hypothyroid, 3.36% had subclinical hypothyroidism. 4.8% were hypothyroid, and 1.17% had subclinical hypothyroidism.
13 pts (0.7%) had nodular Goiter that in one case it was diagnosed as papillary carcinoma. Three patients had coid nodules and the rest had multiple warm nodular or diffuse Goiters. In 44.3% of cases Goiter was in grade IA and in 34% cases it was graded as IB. Goiter was the most prevalence (32.5%) in 10-19 age group and it was least prevalence (2.1%) in pts over 70.
Conclusion: Goiter is endemic in Markazi Province, but its prevalence in the children of recent decade is declining and in previous decades, clinical and subclinical forms of hypothyroidism and hypothyroidism are more prevalent.
Mohammad Ali Shariatzadeh, Ghasem Mosayebi, Naser Mahdavi Shahri , Ehsanollah Ghaznavirad, Ali Fani, Abdolrahman Dezfulian, Ali Chehreei ,
Volume 6, Issue 3 (Autumn 2003)
Abstract
Introduction: Insulin-dependent diabetes mellitus (IDDM) or type 1 diabetes is an organ-specific autoimmune disease that caused by destruction of insulin-producing beta cells of the pancreas. Etiology of this disease is still unknown. It is seen that genetic and environmental factors play an important role for susceptibility to develop type 1 diabetes. The relationship between HLA associated factors and susceptibility to IDDM disease, was reported by several investigators. Also, some studies show that dermatoglyphics is associated with type 1 diabetes. However, it is maybe there is an association between HLA and dermatoglyphics inpatients'with type 1 diabetes and these characteristics could be applied for diagnosis of disease.
Materials and Methods: In this study, the prevalence of HLA (with using standard microlymphocytotoxicity method) and dermatoglyphics determined in 30 Iranian patients with IDDM and 30 normal healthy controls with similar ethnic background and the same geographical area.
Results: A significantly higher frequency of HLA-DQ, A2, DR3 and DQ2 were found in IDDM cases compared to the controls. The results obtain from dermatoglyphics showed that line ab was reduced in male and female type 1 diabetes. The reciever operating chractristics curve showed that the positive point for lines ab in right and left hands were 34.7 and 35.25, respectively.
Discussion: There is no association between HLA and dermatoglyphics.
With considering of genes encoding of HLA separated from genes determining dermatoglyphics, HLA typing and dermatoglyphics seem to be interesting tools for genetic studies related to type 1 diabetes. Further studies are recommended in order to provide more insight into the susceptibility to this disorder.
Ali Fani, Iman Fani, Ramin Ghahremani, Abass Mohseni, Hamid Reza Soltani,
Volume 7, Issue 2 (Summer 2004)
Abstract
Introduction: Although more than two decades is passed from the discovery of H.pylori and its role in pathogenesis of upper GI disease, a uniform protocol for H.pylori treatment is not administrated yet. This research is conducted to evaluate knowledge, attitude and practice of physicians about H.pylori disease and treatment and its changes after reading a review article.
Materials and Methods: This is an interventional study. First we prepared a compact, review article for the purpose of teaching H.pylori pathophysiology, diagnosis and treatment. Then thirty questions was brought out to evaluate knowledge, attitude and practice of the physicians about H.pilory diagnosis and treatment. After the first evaluations we gave our article to the physicians to study. One month later we repeated the evaluation with the same questionnaire. Data was analyzed by SPSS software.
Results: 304 physicians participated in this study. The mean evaluated knowledge was 49.64-58.75 with 95% confidence interval; which after education increased to 57.94-74.14 (p<0.05). Mean level of attitude and practice was 53.01-71.67 with 95% confidence interval. After studying it increased to 61.54-80.83 (p<0.05).
Conclusion: The first step of the study showed that test and treat is the protocol of choice for many physicians. After primary evaluation and introducing the compact article there was a noticeable change.
Ali Fani, Iman Fani, Farzaneh Jahani, Mahmood Amini, Mahmood Baghinia , Mohammad Rafiee, Tania Fahimi,
Volume 7, Issue 4 (Winter 2004)
Abstract
Introduction: Acute renal failure (ARF) is one of the relatively incident complications in surgical emergency wards and is defined as increasing serum urea and creatinine and decreasing GRF. In this study we investigated acute renal failure incidence in patients admitted to emergency surgical ward.
Materials and Methods: This is a cross sectional analytical study in which all patients with primary diagnosis of emergency surgery (traumatic or non traumatic) admitted in emergency surgery ward were selected. After history taking and physical assessment patients having history of kidney disease were excluded. Urinalysis, BUN and creatinine tests were performed for all samples. Data was analyzed by SPSS software.
Results: In this study 2100 patients (1280 male) were assessed during a 10 month period. 5.66% of samples had some degree of ARF. 1136 patients undergone surgery due to accidents and trauma (72% multiple trauma and 28% single trauma) and 964 patients due to nontraumatic emergencies. ARF was seen in 6.84% of the first and 4.25% of the second group. ARF incidence in male and female was 5.6% and 5.7% respectively.
Conclusion: The overall incidence of ARF in this study was not so different from developed countries. ARF was significantly more incident in traumatic (especially multiple trauma) and old aged patients. This factors must be considered as ARF risk factors in emergency wards.
Dr Ghasem Mosayebi, Dr Ehsanola Ghaznavi Rad, Dr Ali Fani, Dr Seyedmohammad Moazenni,
Volume 8, Issue 3 (1-2006)
Abstract
Insulin dependent diabetes mellitus, human leukocyte antigens
Introduction: Insulin dependent diabetes mellitus (IDDM) or type 1 diabetes is created by autoimmune destruction of insulin-producing beta cells of the pancreas in genetically susceptible individuals. The relationship between human leukocyte antigens (HLA) associated factors and susceptibility to IDDM disease, was reported by several investigators. Association with different HLA types depends also on the studied populations. The aim of the present study was to determine HLA antigens which represent a high susceptibility to develop the IDDM disease in this area. Materials and Methods: In this study, the prevalence of HLA class-I and II antigens has been determined in 31 Arakian patients with IDDM and 57 normal healthy controls with similar ethnic background and from the same geographical area. The typing of HLA antigens was carried out using standard microlymphocytotoxicity method. Results: A significantly higher frequency of HLA-A2, A3, B21, DR3 and DQ2 were found in IDDM cases compared to the controls. In contrast, HLA-DR2, DR7 and B53 were represented at a somewhat higher frequency in controls compared to the IDDM patients. Conclusion: These results indicate that HLA-A2, A3, B21, DR3 and DQ2 antigens contribute to susceptibility to IDDM independently and HLA-DR2, DR7 and B53 antigens maybe associated with prevention of IDDM in Arakian patients.
Behnam Ghalenoei, Ali Fani, Shima Monzavi, Masoumeh Shokri,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: Peptic ulcer is a condition in which there is an ulcer in the stomach or duodenum. The incidence of peptic ulcer is 5 to 10% and is more prevalent in men. Infection with helicobacter pylori, NSAIDS, smoking and alcoholism are of the most important risk factors. Another risk factor is the O blood group. Since most research in this field are done abroad this study is done with the aim of determining the relation between ABO blood group and Rh with peptic ulcer. Materials and Methods: In this case-control study, 325 persons with dyspepsia were investigated. These individuals were referred for endoscopy. The case group consisted of 110 persons in whom endoscopy had revealed a peptic ulcer and control group 215 persons in whom endoscopy had showed no sign of ulcer. Blood grouping was performed by slide and tube methods .Chi square test was used for data analysis. Results: Based on the results, patients’ age was between 18-75 years. 68.6% of samples were women because they had more referrals. There was a significant relation between age and sex with peptic ulcer. 25.5% of patients were single and 72.5% married. Among all samples 32.9% had A blood group, 18.5% B, 11.1% AB and 37.5% O and 88% were Rh positive and 12% Rh negative. There was no significant relation between ABO blood group and Rh with peptic ulcer. The gathered data was analyzed using odds ratio, relative risk and Chi square test. Conclusion: Although some investigations have showed correlations between ABO blood group and peptic ulcer, our data showed no correlation. This may be due to the prevalence of helicobacter pylori infection among patients with peptic ulcer which needs more investigations. Other effective factors may be life style and nutrition.
Hossein Sarmadian, Nader Zarinfar, Ali Fani, Fateme Marjan Mousavi, Farshideh Didgar, Mohsen Khaki, Azadeh Mohammad Bagheri, Maryam Karimi,
Volume 11, Issue 3 (9-2008)
Abstract
Background: Metronidazole has antibacterial and antiparasitic action. Therefore it can use for treatment inflammatory diseases as Crohn. The effect of metronidazole on human’s blood lipids to reducing levels of LDL and VLDL and increasing level of HDL is under investigation. Target of this research is consideration effect of metronidazole on hyperlipidemia case of death such as coronary artry disrase. Methods and Materials: This study is a triple blind clinical trial was done on 100 voluntaries between 25-65 years old. with hyperlipidemia. Samples divided in two equal groups. The first group received metronidazol, 500mg, BID, for 10 days, and control group received placebo with the same dose. Lipids of serum were measured before and after using drugs, then data analyzed by SPSS software. Results: In metronidazol group amount of total cholesterol, LDL and Triglyceride were significantly less than placebo group. HDL’s amount in metronidazole group was significantly more than placebo group. Conclusion: Significant effect of metronidazole on reducing harmful blood lipids and increasing useful blood lipids. It can be suggested a probable candidate in treatment of hyperlipidemia. Maybe it can use with this application. Although it needs to more study by meta analysis to validate this effect.
Neda Baghy Nia, Shahrbanoo Oryan, Ali Fani, Aliakbar Maleky Rad,
Volume 11, Issue 4 (12-2008)
Abstract
Background: Imbalance between the production of free radicals and the antioxidant defense system causes oxidative stress. The cardamom is the fruit of the Elettaria cardamomum maton which probably has an antioxidant property. Aim of this study is assess of effect of cardamom- tea watery extract on oxidative stress.
Methods and Materials : This clinical trial research was carried out on 54 persons. Firstly 5ml venous blood was collected and the parameter of the oxidative stress in their blood was evaluated. Then they were given every day 3 grams of cardamom and 1 gram of tea as like as 100 ml cardamom- tea watery extract for two weeks. After 2 weeks 5 ml blood was collected and the parameters of oxidative stress in their blood serum was evaluted for the second time. The parameters of first and second group of bloods were compared by SPSS software.
Results : The mean of total antioxidant capacity of serum before and after cardamom- tea extract were 1.96 ± 0.64 m mol/ml and 2.23 ± 0.46 m mol/ml respectively (p=0.009). The mean of lipid peroxidation before and after cardamom- tea were 14.97 ± 3.58 nmol/ml and 12.07 ± 5.91 nmol/ml respectively (p=0/002). The mean of total thiol group before and after cardamom- tea were 0.224 ± 0.200, 0.266 ± 0.166nmol respectively (p=0.141).
Conclusion: The cardamom- tea reduces the amount of lipid peroxidation and enhanced the antioxidant markedly. So, the cardamom- tea decreases the amount of oxidative stress in blood. Ther- fore the cardamom- tea in the people diet is usful.
Ali Hekmatnia, Iman Fani, Ali Fani, Masoud Fazeli, Javad Marashi,
Volume 12, Issue 4 (2-2010)
Abstract
Background: The use of proper contrast agents is very effective in improving the quality of medical imaging. In this study, we dealt with the effect of high PH blackberry juice accompanied with omeprozole in reducing the upper fluid artifact in MRCP images. Methods: This single blinded before-after clinical trial was done with the enrollment of 34 patients. After receiving official agreement from the patients and applying the enrollment criteria, they were ordered to take two 20mg omeprozole capsules the night before the exam. The next day, while they had been held NPO, they were exposed to the first MRCP. After this, they drank 300cc blackberry juice and were re-examined after 15 minutes. The related checklists were printed and three radiologists independently inspected the reduction of artifact checklists and the resolution of images. Eventually, the quality of images and the mean of artifact reductions in the images before and after black berry Juice consumption were compared. Results: Reduction of artifact scores due to gastrological secretions did not show any significant differences before and after black berry juice consumption (2.97±0.37 and 2.89±0/87, respectively). Additionally, no significant changes were observed in the visibility of gall bladder, water ampoula, common hepatic duct, intrahepatic ducts and head of pancreatic duct images. There was a decrease in the common bile duct visibility (p=0.01). In the case of pancreatic duct tail and body visibility, images showed improvements (p=0.04 and 0.03, respectively). Conclusion: Blackberry juice, as a contrast agent, does not seem to have enough paramagnetic metals and does not improve the quality of MRCP.
Ali Fani, Parisa Fani, Mohammad Rafiei, Navid Reza Mashayekhi, Reza Shahmirzaei, Khosro Minavand,
Volume 13, Issue 1 (4-2010)
Abstract
Background: Aspirin (ASA) and helicobacter pylori infection are two major known risk factors for peptic-ulcer. This research aims to examine the interaction between helicobacter pylori and low dose ASA in inducing gastro-intestinal complications. Materials and Methods: The target group consisted of patients with cardiovascular disease who were under low dose ASA therapy. Patients, who had symptoms of dyspepsia, were placed in the case group and those who did not have these symptoms were placed in the control group. 5cc blood samples, required for conducting ELISA Ab., were taken simultaneously in both of the groups. ELISA positive patients underwent UBT test. UBT positive patients were categorized as helicobacter pylori positive and those with negative UBT were placed in the helicobacter pylori negative group. Finally, the ratio of dyspepsia incidence probability to Aspirin usage and helicobacter pylori infection was analyzed. Results: Of the 129 individuals present in the control group and 71 individuals who were in the case group, 72(36%) were UBT positive, and the rest were UBT negative. Of all the patients, 35.5% had dyspepsia and there was a significant difference between UBT positive and UBT negative individuals (p=0.001, OR=6.54). of 43 patients who had signs of intensified dyspepsia 23 persons under went endoscopy assessment which 20 of them were diagnosed with peptic ulcer. Eighty percent of the patients who had developed peptic ulcer, were UBT positive which revealed a significant difference with UBT negative (p=0.001, OR=8.86). Conclusion: In order to reduce gastro-intestinal complications, it is suggested that long term low dose Aspirin takers be subjected for screening and to receive treatment in terms of infection with helicobacter pylori and clinical manifestations.
Ali Fani, Mohsen Ghasedi, Fatemeh Esmaeeliun, Behrouz Alizadeh,
Volume 13, Issue 3 (9-2010)
Abstract
Background: Irritable bowel syndrome (IBS) which is characterized by chronic abdominal pain and changes in bowel movements is the most common gastrointestinal disease. Curcuma is one of the traditional medications which has been considered in treatment of gastrointestinal diseases. In this study, the effects of curcuma on IBS were investigated. Materials and Methods: In a double-blind randomized study, 140 IBS patients after meeting the inclusion and exclusion criteria, regardless of sex and age and based on internist’s diagnosis, were involved. The patients were randomly divided into case (curcuma) and control (placebo) groups which included 69 and 71 patients, respectively. For converting subjective criteria to objective ones, treatment forms were filled out before the treatment and two and four weeks after the treatment according to visual analog scale. Data were analyzed through descriptive statistics and t-test. Results: Using curcuma and placebo before the treatment and two and four weeks after that improved patients’ clinical symptoms except for vomiting (p=0.001) however, no significant differences were observed in the effectiveness of placebo and curcuma on improvement of clinical symptoms of patients in case and control groups (p>0.05). Conclusion: Using curcuma does not offer any significant differences in controlling and reducing the symptoms of IBS in comparison to the placebo, but its application improves the clinical symptoms of IBS patients.
Ali Akbar Malekirad, Ali Fani, Mohammad Abdollahi, Shahrbanoo Oryan, Vahhab Babapor, Seyed Mohhamad Ali Shariat Zadeh, Morteza Davodi,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Lead (Pb) brings about a variety of cognitive, mental, renal, and blood system disorders by inducing oxidative stress. The aim of this study is to compare blood and urine parameters in the workers exposed to Pb and zinc (Zn) with those in the control group. Materials and Methods: An analytical cross-sectional study was conducted with a total number of 134 subjects. The case group included 67 male workers with the age range of 22-65 who had at least worked a minimum of one work shift for two years in the Zn-Pb mine located in the southwest of Arak, Iran. Control subjects consisted of 67 farmers of a village near the mine who had no history of occupational exposure to Pb, Zn, and other metals. Mental disorders were evaluated through the standard Scl-90-R while cognitive disorders were evaluated via the Mini Mental Status Examination (MMSE). Results: The mean level of blood and urine parameters did not reveal significant differences between the two groups. The mean scores of physical complaints, anxiety, and aggression scales were significantly higher in the case group than the control (p<0.05), whereas the mean scores on MMSE did not reveal a significant difference between the two groups. Conclusion: The oxidative stress of Pb led to mental disorders as a result, the mine workers suffered from more psycho- pathology and are in need of greater care. Due to the impacts of Pb and Zn, the proper use of safety equipments and taking daily showers can reduce the risk of absorption of toxic agents and their subsequent hazards for workers.
