Khadijeh Arjmandi Rafsanjani, Ali Chehrei, Majid Chalian, Shayan Shojaei, Ali Fahimi, Pedram Golnary,
Volume 5, Issue 3 (Autumn 2002)
Abstract
Introduction: Wilms' tumor is the most common malignant and primary renal tumor in children. Studies, which have been done in some countries, have introduced numerous factors such as age of incidence, stage, lymphadenopathy, histopathology and etc. Effective in the survival rate of this tumor according to the importance of this tumor in children, we decided to perform a study about the survival rate of Wilms' tumor and the effective factors on it.
Materials and methods: This is an analytic study on 128 patients affected with Wilms' tumor whom referred to the oncology ward of Hazrat-e-Ali Asghar Hospital between 1977 and 2001. In addition to the current status of the patients, demographic characteristics, signs and symptoms, laboratory studies at the time of diagnosis and the stage of the disease were recorded and ultimately survival analysis was performed using the Kaplan-Meier procedure and life table. Cox Regression was used to determine the effective factors.
Results: The mean survival rate was 82.99 months. The number of patients was equal in both genders (64 patients in each gender) and the survival average did not have any significant statistical relationship with gender (power=%92.4). Most of the tumors were in stage 3 at the time of diagnosis. The survival of the patients was reducing significantly with the progression of the stage of tumor (P=0.002). The existence of metastasis (P=0.000, odds ratio=0.207), splenomegaly (P=0.018, odds ratio=0.336), and recurrent (P=0.037, odds ratio=0.184), were significantly reducing the survival of the patient. To determine the severity of effective factors on the survival rate of the patients Cox Regression Method was used in which, absence of metastasis and positive blood group were from well-prognosis predictive factors in these patients.
Conclusion: 5-year survival rate of the patients was 63.28% in this study. Which was lower in comparison with the results of other studies in other countries. This can be the result of delay in consulting with medical centers, the diagnosis method and or the Referral State of this center. Recent studies have shown that age and tumor size has minimal values in the prognosis of the patients due to improvement in the quality of treatment and our study support this idea. Genetic factors will probably be used in determining the survival of these patients and also in thcir treatment.
Ali Fani, Iman Fani, Farzaneh Jahani, Mahmood Amini, Mahmood Baghinia , Mohammad Rafiee, Tania Fahimi,
Volume 7, Issue 4 (Winter 2004)
Abstract
Introduction: Acute renal failure (ARF) is one of the relatively incident complications in surgical emergency wards and is defined as increasing serum urea and creatinine and decreasing GRF. In this study we investigated acute renal failure incidence in patients admitted to emergency surgical ward.
Materials and Methods: This is a cross sectional analytical study in which all patients with primary diagnosis of emergency surgery (traumatic or non traumatic) admitted in emergency surgery ward were selected. After history taking and physical assessment patients having history of kidney disease were excluded. Urinalysis, BUN and creatinine tests were performed for all samples. Data was analyzed by SPSS software.
Results: In this study 2100 patients (1280 male) were assessed during a 10 month period. 5.66% of samples had some degree of ARF. 1136 patients undergone surgery due to accidents and trauma (72% multiple trauma and 28% single trauma) and 964 patients due to nontraumatic emergencies. ARF was seen in 6.84% of the first and 4.25% of the second group. ARF incidence in male and female was 5.6% and 5.7% respectively.
Conclusion: The overall incidence of ARF in this study was not so different from developed countries. ARF was significantly more incident in traumatic (especially multiple trauma) and old aged patients. This factors must be considered as ARF risk factors in emergency wards.