Hamidreza Momeni, Afsane Elyasi,
Volume 3, Issue 2 (Summer 2000)
Abstract
In this research, factors such as animal handling, needle effect for saline injection and blood sampling from retro-orbital sinus, etc… were considered as stress-producing factors. Before percutaneous injection of the sterile saline for determination of the blood glucose base and at certain times after injection, serial blood samples were obtained from retro-orbital sinus and then the blood glucose was measured. The experiments showed that one-time injection of 10mg/kg saline caused a little hyperglycemia and two-time injection of saline at the interval of 90 minutes caused a significant hyperglycemic response in comparison to control group of the mice which received one-time injection of saline. The results of the studies indicate that stress-producing factors cause stimulation of sympathoadrenal and hypothalamus – hypophisis- adrenal axel and as a result it causes an increase in plasma catecolamines and cortisole and finally by different mechanisms causes hyperglycemia.
