Introduction: This study was to examine the effects of endurance training and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus.

Materials and Methods: Twenty eight Wistar rats were divided into four groups: (1) Regular diet-sedentary (RD-Sed), (2) Regular diet-Exercise (RD-Exe), (3) HF-sedentary (HF-Sed), and (4) HF- Exercise (HF- Exe) RD-Sed group was regarded as control. Animals in exercise groups received 8-wk endurance training and animals in HF groups were exposed to the HF diet for 8-wk. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at p<0.05.

Results: The results showed that the endurance training had no significant increase in BDNF protein level comparison with the RD-Sd and HF-Sed groups moreover the high-fat diet had no significant effect in BDNF protein level.

Conclusion: According to results of present study, looks applications of endurance training can increase amount of hippocampus BDNF protein level.

Background: Celiac disease (CD) is an immune-mediated inflammation of the small intestine which caused by sensitivity to dietary gluten and related proteins in genetically sensitive individuals. This research aimed to investigate of comparison big five factors of personality and early maladaptive schemas among celiac people and normal people.

Materials and Methods: The research method was ex post facto and statistical population included all people with Celiac whose 108 patients were selected by convenient sampling and 108 normal people were selected by convenient in 4 universities of nursing, psychological, literature and accounting of Azad University in Karaj city. Both groups responded brief five factors questionnaire of NEO personality characteristics and Yang’s early maladaptive schemas. Data were analyzed by using independent t-test, analysis of variance and Multivariate Analysis of Variance, Ben Frooni test, Landa test Wickelz and SPSS version 19.

Results: Results indicated that from five main factors of personality, score of psycho -lesion of patient with celiac were more than normal people. Also, patient’s scores in early maladaptive schemas (emotional baffling, lack of trust, fault/shameless, social recluse/ strangeness, attachment/inefficiency, vulnerability toward loss or sickness, not self –maturing/ engaged, failure, fitness/modesty, self-denial, insufficient self-discipline, servitude, self –sacrifice/ aggressive criteria, extreme criticize and emotional inhibition) were higher in comparison with normal people.

Conclusion: This study revealed that according to influence of early maladaptive schemas on celiac sickness, psychological training courses and schema therapy in order to improve emotional and cognitive patterns of these patients.