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Background: Nowadays, mothers have ceased to breastfeed due to several factors and resort to bottle-feeding or other forms of complementary feeding for their children. This results in physical and emotional problems for children, and socio-economic harms in communities. The aim of this study is to assess the impact of BASNEF model based education on successful breastfeeding in pregnant mothers referring to health centers in Arak. Materials and Methods: This quasi-experimental study was carried out with the participation of 88 pregnant women. The participants were randomly allocated to interuention and control groups. Instructions were given in four sessions on the basis of BASNEF model and behavioral objectives. Eventually, the collected data were analyzed by using statistical tests. Results: Mean scores of knowledge, attitude, enabling factors and subjective norms in the inerurntion group before and after education showed a significant difference in comparison with control group (p<0.001). Conclusion: Model-based education has positive impacts on behavior improvements. Thus, in health programs instead of applying traditional instructions, appying planned education programs based on health education models that have measurable and reliable effects is suggested.

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Background: Molybdenum is an essential trace element for both animals and plants. Molybdenum (Mo), which functions as a cofactor for a limited number of enzymes including xanthine dehyrogenase, aldehyde oxidase, and sulfite oxidase in mammals, is believed to be an essential trace element in animal nutrition. The aim of this study is to evaluate the hepatoprotective potential of sodium molybdate against carbon tetrachloride (CCl4) induced liver damage. Materials and Methods: In an experimental study, adult male rats received daily oral administrations of different doses of sodium molybdate (0.05, 0.1, and 0.2 g/kg bw) along with intrapertioneal CCl4 (50% CCl4 in olive oil, 1 ml/kg bw) twice a week for 28 consecutive days. Results: Histopathological examinations in CCl4-treated rats showed extensive liver injuries characterized by extensive hepatocellular degeneration and necrosis, fat degeneration, and inflammatory cell infiltration while histopathological changes induced by CCl4 were significantly attenuated by sodium molybdate treatment. Conclusion: The results of this study suggest that sodium molybdate could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to the protection of liver by preventing the toxic chemical reactions which generate oxidative stress, lipid peroxidation, and molecular changes which ultimately lead to liver tissue necrosis.

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Background: Pseudomonas aeruginosa is one of the most important causes of nosocomial infection which due to extended spectrum-beta lactamases (ESBLs) and metallo-beta lactamase (MBL) producing strains is resistant to a wide range of antibiotics. The aim of this study was to detect ESBL and MBL producing P.aeruginosa isolated from patients and investigate the effects of methanol extracts of Zataria multiflora, Myrtus communis, and Peganum harmala on them. Materials and Methods: In this experimental study, samples were obtained from 245 patients, referring to Shafa Hospital, Kerman, Iran. ESBLs producing strains were detected by double disk synergy test and phenotypic confirmatory test. In addition, E-test strips were used for MBL detection. P.aeruginosa MIC was determined for cefotaxime, ceftazidime, azteronam, imipenem, and meropenem. Methanol extracts of Zataria multiflora, Peganum harmala, and Myrtus communis plants were prepared by Agar perculation method. Results: Out of 245 patients referring to the burn unit, 120 P.aeruginosa isolates were detected from which 41 contained ESBL but they lacked MBL. 60% of isolates were resistant to cefotaxime, 66% to ceftazidime, 42% to azteronam, 3% to imipenem, and 5% to meropenem. Among the extracts, Zataria multiflora had the highest antibacterial effect on standard strains of P.aeruginosa in comparison with Peganum harmala and Myrtus communis. Conclusion: The prevalence of ESBL producing P.aeruginosa strains is high. In addition, noticing their high antibiotic resistance, utilization of herbs, such as Zataria multiflora may be considered an appropriate alternative for treatment however, more investigations are needed.

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Background: The major aim of this study was synthesis and assay of antimicrobial activity of peptide D28 and its new analogues derivatives as dimeric peptides. Materials and Methods: Three antimicrobial peptides known as D28, Di-D28-Lys,Di-Cys-D28 including 20, 41, 42 residues were synthesized respectively. For peptide synthesis, solid phase peptide synthesis method using blocked amino acids with flourenyl methoxy carbonyl group and for peptide purification HPLC were used. Peptides compositions were confirmed by amino acid analysis and SDS-PAGE electrophoresis. Antimicrobial tests against Staphylococcus aureus and Pseudomonas aeruginosa were performed as disk and well diffusion on plate and by adding to liquid broth culture (Broth macrodilution) in different concentrations. Results: Three required peptides (D28, Di-D28-Lys, Di-Cys-D28) successfully were synthesized. All three peptides were effective against S. aureus, but Di-Cys-D28 on the contrary to two other ones, showed no antimicrobial activity against P. aeruginosa. The inhibitory activity of Di-D28-Lys against P. aeruginosa was more than that of D28 peptide. Conclusion: Improvement of antimicrobial peptides activity through dimerization depends on the methods of dimerization and the strain of bacterium. Di-D28-Lys peptide in comparison with D28 and Di-Cys-D28 showed wide range and more antimicrobial activity. Therefore, Di-D28-Lys peptide could be a suitable antibiotic candidate for future studies.

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Background: Use of inappropriate drugs in the elderly is a major health care concern. It is likely to increase adverse drug reactions and induce a substantial increase in health care costs. The aim of study was to evaluate inappropriate drug use in the elderly.

Materials and  Methods: In this cross-sectional study, collecting data were collected from patient’s file for 260 patients aged 60 years who were admitted to Rasoul-e-Akram Hospital in 2012. Potentially inappropriate medications were identified based on the 2012 Beers criteria.

Results: The mean age of the patients was 75±8.3 years. Overall, 58(22.3%) of the patients were treated with potentially inappropriate medications. The most common inappropriately prescribed medications were benzodiazepines, pethidine, and TCAs.

Conclusion: To improve prescription quality in elderly patients in Iran, preparing a scientific criterion or guideline is necessary.

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Background: Today, the consumption of junk food as a snack among children, especially in elementary school students is on the rise. This research has measured Theory of Planned Behavior constructs in this field.

Materials and Methods: This is a cross-sectional and analytical study that was carried out on 217 primary school students in Arak city in 2015. Students were selected according to cluster sampling method. Data collection instrument was a researcher-developed questionnaire consisting of theory of planned behavior constructs such as attitudes, subjective norms, perceived behavioral control, behavioral intention and performance. Reliability and validity of the questionnaire was studied before the study. Multivariate linear regression model was used to determine the most important predictive constructs of students behavior.

Results: In this study, the mean and standard deviation score of attitude (75.41±12.42), subjective norm (78.25±11.20), perceived behavioral control (63.69±17.06), behavicral intention (76.26±15.44), and performance (48.84±24.44) were observed. Based on the results, perceived behavioral control could predict 23 percent change in behavior. There was a direct correlation between the score of constructs and performance(p<0.05). Moreover, there were not any significant differences(p>0.05) between students nutrition and age(r=0.019), weight (r=0.07), height (r=0.12) and BMI (r=0.07).

Conclusion: The results of this study suggested that positive attitude and self-esteem must taken into account to control students diet, in the design of interventions to prevent consuming junk food.

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Background and Aim: Children with Attention Deficit Hyperactivity Disorder are a good target group for cognitive rehabilitation Because their behavioral problems, including inattention, impulsivity, and hyperactivity, have a specific cognitive and cerebral origin. This adaptation of behavior to cognitive function provides an opportunity to repair behavior by strengthening cognitive function. This study aimed to compare the effectiveness of cognitive rehabilitation based on virtual reality technology as a new method and classical cognitive rehabilitation in improving the executive functions of children with attention deficit hyperactivity disorder.
Methods & Materials: This research was a quasi-experimental study using a pre-test-post-test design with a control group. The statistical population included all children aged 7-12 years with Attention Deficit Hyperactivity Disorder in Tehran in 1398 who were selected by convenience sampling method and randomly divided into 3 groups of 12 people. In the pre-test stage, participants were assessed with the Attention Deficit Hyperactivity Disorder Rating Scale and the Computer Integrated Visual and Auditory Test (IVA-2). The first group received a virtual reality-based cognitive rehabilitation package and the second group received a Captain Log computer cognitive rehabilitation package, 12 sessions twice a week. No intervention was performed in the control group during this period. Post-tests were taken from all 3 groups after the intervention. Univariate analysis of covariance (ANCOVA) was used to analyze the data using SPSS software v. 26.
Ethical Considerations: This study was approved by the Research Ethics Committee of the Islamic Azad University, Central Tehran Branch (Code: IR.IAU.CTB.REC.1400.001). 
Results: The results showed that both methods of cognitive rehabilitation intervention had a significant effect on cognitive functions (selective attention, sustained attention) of Attention deficit hyperactivity disorder (ADHD) children (P<0.01). But no significant difference was observed between the mean scores of selective attention and sustained attention in the first experimental group and the second experimental group (P>0.05). 
Conclusion: Virtual reality-based cognitive rehabilitation is as effective as classical cognitive rehabilitation on selective attention and sustained attention in children with ADHD. Virtual reality-based cognitive rehabilitation can be used as a new approach to rehabilitating this disorder.