Mehrdad Roghani, Torandokht Baluch Nejad Mojarad ,
Volume 7, Issue 4 (Winter 2004)
Abstract
Introduction: Experimental animals like diabetes rats display an augmented nociceptive response to chemical, mechanical and thermal stimuli in long term. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of chard, this study was carried out to evaluate the possible analgesic effect of chard-mixed food intake in male streptozotocin-induced diabetic rats.
Materials and Methods: In this study rats were randomly divided into control, chard-treated control, salicylate-treated control, diabetic, and chard-treated diabetic groups. At the end of experiment, nociceptive response was evaluated in both acute and chronic phases of the standard formalin test based on a four level scale.
Results: Results showed that there was a significant increase in the number of pain scores in both acute and chronic phases in diabetic rats, and administration of chard for one month did not significantly reduce the pain scores in both phases of the test. Meanwhile, sodium salicylate as positive control, only reduced this score in the second phase.
Conclusion: It can be concluded that oral administration of chard for one month despite of its antidiabetic potential could not significantly reduce the nociceptive responses in diabetic rats.
