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Introduction: Nausea and vomiting are a common manifestation in anatomic and functional disorders and these are current complication after general anesthesia and are unpleasent and with secondary complication. Nausea and vomiting are the most common complications after general anesthesia. Materials and Methods: In this study we compared three methods which one of them is droperidol with other methods consisting of IV metoc1opramide and placebo. This controlled study was done in teaching Vali Asr hospital. Total number of patient was 300. Type of sampling was random. Type of operation was laparatomy and all of them had general anesthesia. We divided them in three equal groups (droperidol group, metoclopramide group and placebo group). In this study we used from history and examination and we finished puzzles and we use from statistication. Results: We concluded that there is valuable difference between metoclopramide and droperidol group (with considering P=0.000). The results were shown that: droperidol is more effective than metoclopramide in the prevention of postoperative vomiting after abdominal surgery. Conclusion: With comparison of these data we fined that droperidol is a suggestive and valuable method also effective method in preventing postoperative vomiting. Also finding were shown that there isn't a meaning relation between age the kind of abdominal surgery and postoperative vomiting.

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Introduction:  Atypical  antipsychotic  drugs  in  comparison  with  typical  antipsychotics  produce  fewer  extra  pyramidal  symptoms  at  clinically  effective  doses.  However  there  has  also  been  a  growing  number  of  reports  of  new  onset  diabetes  mellitus  in  patients  receiving  these  drugs. The  aim  of  this  study  was  the  comparison  of  diabetes  mellitus  incidence  in  mentally  janbazan  (Iran-Iraq  war  veterans) undertaken  typical  with  atypical  antipsychotics.
Materials  and  Methods: In  this  study  the  incidence  of  new  onset  Dm  was  assessed in 200  subjects  referred  to  Amiralmomenin  clinic, Isfahan, Iran. Every  patient  was  included  in  this  study  if  he  was  receiving  atypical  or  typical  antipsychotic  drugs  or  combination  of  both  types, at  least  for  one  year.  Sampling  was  convenient. Fasting  blood  sugar, triglyceride  and  cholesterol  before  taking  the  drugs  was  documented  in  their  records. New  onset  DM  was  defined  based  on  126  mg/dl  or  more  for  FBS  which  was  confirmed  with  GTT.  For  comparison  of  FBS  mean  pre  and  post  interventions, NIDDM  incidence, the  relation of  background  variables  with NIDDM  and  the  relation  of  NIDDM  incidence  with  dosages  and  duration  of  drug  therapy, paired t-test, chi-square, logistic  regression  and  ANOVA  were  used.
Results: Subjects  were  divided  into  three  groups  based  on  the  type  of  drugs  used  135 patients  using  typical  antipsychotics  (chlorpromazine, perphenazine, haloperidol, …), 39 patients  using  atypical  antipsychotics  (clozaoine  &  riaperidon)  and  26  patients  receiving  combination  of  drugs. It  was  found  that  DM  developed  following  treatment  in  three  groups  were  12.8%, 6.7%  and  3.8% respectively.  There  was  no  significant  differences  between  three  groups  regarding  the  incidence  of  new  onset  DM.
Conclusion:  Findings  showed  that  patients  treated  with  antipsychotic  drugs  had  a  moderately  increased  risk  of  DM especially  with  atypical  antipsychotics.  It  is  suggested  to  evaluate  every  patients  before  treatment  for  risk  factors  of  DM.
 

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Background: Marital conflicts have great impact on social, economic and cultural aspects of the couples and their children. New Psychological interventions like “Imago Relationship Therapy” (IRT) have been widely used for resolving these conflicts. This study examined the efficacy of couple dialogue technique on marital relationship and children`s behavior in Iranian society. Methods and Materials: In a Clinical Trial study eighty consecutive couples refered to general pediatric clinics due to their children’s diseases, randomly allocated to intervention group(couple dialogue technique) and control group (consult usual treatment method) in consultation center. They filled "Distance and Isolation Questionnaire" and "Gottmann Love and Respect Scale" at baseline, post treatment and three months after intervention as follow up all of them. General linear Model with Repeated Measurements was used to analyze the data. Results: In this study, scores of mutual love and respect in marital relationship (Gottmann scale) and scores in Flooding, Loneliness and Retreatment subscales of Distance and Isolation Questionnaire had a better condition in IRT group just after the trial (P<0.05) but after three months, the differences between two groups were only marginal significant (P<0.1). In Parallel lives` subscale, scores were decreased in two groups, but right after trial there was not significant scores of the groups did not difference between scores. Scores after three months in IRT group was significantly lower in compare to control group. Scores of CBCL have not statistically significant differences in both groups at any time (P>0.05). Conclusion: This study revealed couple dialogue technique was an effective intervention in solving marital conflicts in Iranian population but had not a significant effect on children’s behavioral profile. This may be due to other factors or insufficient duration of intervention and needs more investigation and needs more investigation.

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Background: Metronidazole has antibacterial and antiparasitic action. Therefore it can use for treatment inflammatory diseases as Crohn. The effect of metronidazole on human’s blood lipids to reducing levels of LDL and VLDL and increasing level of HDL is under investigation. Target of this research is consideration effect of metronidazole on hyperlipidemia case of death such as coronary artry disrase. Methods and Materials: This study is a triple blind clinical trial was done on 100 voluntaries between 25-65 years old. with hyperlipidemia. Samples divided in two equal groups. The first group received metronidazol, 500mg, BID, for 10 days, and control group received placebo with the same dose. Lipids of serum were measured before and after using drugs, then data analyzed by SPSS software. Results: In metronidazol group amount of total cholesterol, LDL and Triglyceride were significantly less than placebo group. HDL’s amount in metronidazole group was significantly more than placebo group. Conclusion: Significant effect of metronidazole on reducing harmful blood lipids and increasing useful blood lipids. It can be suggested a probable candidate in treatment of hyperlipidemia. Maybe it can use with this application. Although it needs to more study by meta analysis to validate this effect.

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Background: Diabetic patients face many challenges related to their illness and treatment in their life. So they need to use coping strategies for adjustment. The purpose of this study was determined the coping styles among diabetic Iranian patients. Methods and Materials: In a case-control study, 100 consecutive diabetic patients admitted to Amin and Sedigheh Taherah Medical Centers, Isfahan, were selected based on the inclusive and exclusive criteria and compared with one hundred normal people who selected from general population. Data collected by using demographic questionnaire, the Jalowiec Coping Scale, then MANCOVA and co-variance were used to analyze the data. Results: Difference between two groups in coping styles were significant (F=2.835, p=0.005). Significant differences was in supportant coping style (F=11.204, p=0.001). There was no significant difference in other coping styles between two groups. Conclusion: It seems that the diabetic patients likely differ from normal people only in supportant coping style when deal with daily stress. But they are similar to normal people in other coping styles. In addition, both groups use problem solving styles when deal with daily stress. The findings emphasis the role of illness representation to determine coping styles.

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Background: The purpose of this research is to design a Brain-Computer Interface to discriminate the brain signals while the brain images four main directions. To be innovative, the subjects have imaged the aimed directions by power of imagination, and for the first time, the ICA algorithm has been used to detect the aimed signal and to eliminate the artifacts.

Materials and Methods: In this descriptive-ana alytic study, signals are recorded by using a Micromed device and a 19-channel helmet in unipolar mode. The statistical population included three persons in the age range of 25 to 30 and the designed task consisted of 24 slides of four main directions.

Results: Simulations have shown that the best classification accuracy was the outcome of the 2.5-second time windowing and the best choice for extracting features was the AR coefficients of 15 order. There was no significant difference between the classification accuracy of different implementation of the Artificial Neural Network classifier with different number of layers and neurons and different classification functions. In comparison with the Neural Network, the Linear Discriminant Analysis (LDA) showed better classification accuracies.

Conclusion: The results of this research are in accordance with the results of the methods such as FMRI and methods based on the brain signals in vowel imagination. In this research, the best classification accuracy was obtained from the Linear Discriminant Analysis classifier by extracting the target signal from the output of the ICA algorithm and extracting the AR coefficients as feature and the 2.5-second time windowing. The Linear Discriminant Analysis classifier result the best classification accuracies.

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Background: Streptokinase is one of the most common and cost effective fibrinolytic drugs for treatment of heart attacks and vein thrombosis. Unlike many advantages over other thrombolytic drugs, administration of streptokinase can produce some complications such as immunologic reactions, hemorrhage and incomplete treatment due to relative short half life. Pegylation is one of the most common methods for improving of these shortcomings.

Materials and Methods: In this study, designing a proper candidate for specific pegylation with cysteine was done by means of SPDBviewer software. After a meaning ful mutation by SOEing PCR method, mutated (sk45cys) and intact SK (ski) genes were cloned in pET26-b vector and the structures were transformed in E.coli. Clones, Afrer growing, were expressed by IpTG and exptression of proteins was confirmed by SDS-PAGE and western blotting. The proteins were purified by affinity chromatography with NiNTA columns and amidolytic activity of purified proteins was assayed using chromogenic method and different concentrations of S2251 substrate.

Results: Results of activity assays showed that amidolytic activity of SK45cys had about 10% increase in comparison to Ski, after 30 minutes of complex formation with plasminogen.

Conclusion: Generally, it was concluded that, considering cys45 as a superficial aminoacid and also relative increase of activity, SK45cys can be considered a suitable protein for specific pegylation.

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Background and Aim: The concept of resilience has been recently extensively considered concerning sports studies; accordingly, in most qualitative studies, it has been used to explore the attitudes of coaches, athletes, and sports psychologists. In this regard, the present study aimed to determine resilience in athletic students based on dark triad personality and psychological wellbeing.
Methods & Materials: This was a descriptive and correlational study. The population of the study consisted of all male students of Guilan University of Physical Education in the first semester of the academic year 2019-2020. A sample of 200 individuals was selected by convenience sampling method; then, the required data were collected using Sheard et al.’s (2009) Resilience Scale for Adults, Jonsson and Webster’s Dark Triad Personality Questionnaire, and Ryff’s 18-item Psychological Wellbeing Scale (1989). The obtained data were analyzed by SPSS using Pearson correlation coefficient and multiple regression analysis.
Ethical Considerations: This study was approved by Research Ethics Committee of Guilan University of Medical Sciences (Code: IR.GUMS.REC.1398.121).
Results: The present research results suggested a positive and significant correlation  between the resilience of the examined athletic students and narcissism (r=0.495, P<0.001), self-acceptance (r=0.598, P<0.001), purposefulness in life (r=0.556, P<0.001), personal growth (r=0.648, P<0.001), the mastery of the environment (r=0.645, P<0.001), positive correlation  with others (r=0.569, P<0.001), and independence (r=0.381, P<0.001). Moreover, there was a significant negative correlation between antisocial behavior (r=-0.557, P<0.001) and Machiavelli’s aspect (r=-0.604, P<0.001), and the explored students’ resilience. Additionally, multiple regression analysis data revealed that dark triad personality and psychological wellbeing predict 62% of resilience in the study subjects.
Conclusion: The current investigation results signified a significant correlation between dark triad personality and psychological wellbeing, and resilience in athletic students. Accordingly, educators and teachers need to pay more attention to the role of psychological wellbeing and different dimensions of athletes’ personalities for promoting the health and performance of students.

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Ryu S, Nam HJ, Jhon M, Lee JY, Kim JM, Kim SW. Trends in suicide deaths before and after the COVID-19 outbreak in Korea. PLoS One