Background:  The aim of this study was to investigate the effect of resistance training with different intensities on serum myostatin and follistatin levels in sedentary young women.

Materials and Methods: In this practical and semi experimental study, 24 sedentary young women with range of 20-30 years and BMI 22-25 kg/m² were selected by convenience sampling. Then, the volunteers were randomly assigned into two groups, [resistance training group with low intensity (40-60% of one repetition maximum) and high intensity (70-90% of one repetition maximum)]. The training protocols included: 8 weeks, 3 times a week. Blood samples (5cc) were obtained at baseline and 48 hours after at the end of the study; Also Serum levels of myostatin and follistatin were measured by ELISA methods. Data were analyzed using analysis of variance of repeated measures test by SPSS at the significant level (p<0.05).

Results: There was a significant increase in the levels of follistatin and follistatin to myostatin ratio in high intensity group (p≤0.05). Also there was a significant decrease in the levels of myostatin in high intensity group (p≤0.05); however, there was no significant change in the levels of follistatin, myostatin and follistatin to myostatin ratio in low intensity group (p≥0.05). Also there was no significant change in these variables in high intensity group compared to low intensity group (p≥0.05).

Conclusion: It’s seems that the activation of important myogenic and myostatic factors in sedentary young women need to do high intensity resistance training.

Background: The aim of this study was to investigate the response of the most important angiogenic and angiostatic factors to a session activity before and after a period of L-Arginine supplementation in active men.

Materials and Methods: In this practical and semi experimental study, 22 active men were selected by convenience sampling method and they were randomly assigned into supplement (n=11) and placebo (n=11) groups. Baseline levels of VEGF and endostatin were measured, then subjects participated an exhaustive treadmill protocol in pre-test and post-test. Immediately and two hours after the protocol, 3 cc blood samples were prepared. The subjects used daily 0.1 g.kg^-1 respectively taking l-arginine and placebo for 14 days. The results were analyzed at the significant level (p<0.05).

Results: Immediately after exercise, the levels of VEGF and VEGF to endostatin ratio were significantly decreased in both groups compared to baseline (p≤0.05), and two hours later this change were lower than the baseline value (p≤0.05). The levels of endostatin immediately after exercise were significantly increased in both groups compared to baseline (p≤0.05) and two hours later this change were lower than the baseline value (p≤0.05). Before and after L-Arginine supplementation, the levels, of VEGF and VEGF to endostatin ratio immediately after exercise were not significant(p≥0.05). while this change in the supplementation group were significantly increased two hours after exercise (p≤0.05). There was no significant change in the levels of endostatin between two groups immediately after exercise (p≥0.05); however, these changes were significantly decreased two hours after exercise (p≤0.05).

Conclusion: It seems that short-term L-arginine supplementation probably stimulate angiogenesis factors in response to exercise in active men.