Search published articles


Showing 2 results for Ataei
Association of Polymorphism of LRP4 Gene (rs 4752947) among Post Meno-pause Women with Osteoporosis in North of Iran
Saeid Kavoosian, Ali Mohammad Asgharian, Ramin Ataei ,
Volume 19, Issue 8 (11-2016)
Abstract

Abstract

Background: Osteoporosis is describesd as a disorder and skeletal disease that decrease bone strength and increases the risk of a bone fractures. Genetic factors have effect role in the progression of the osteoporosis. The aim of this study was to investigate the association between LRP4 gene polymorphism with osteoporosis in a population of postmenopausal women from north of Iran.

Materials and Methods: In this case-control study, 80 female patients with osteoporosis and 80 healthy females without osteoporosis with average age of 45-60 has been investigated. After DNA extraction from genome samples, polymorphism of LRP4 (rs4752947) gene have been investigated by PCR-RFLP method. Data were analyzed by SPSS software.

Results: Our results showed no significant relationship between polymorphism of LRP4(rs4752947) gene and the risk of osteoporosis disease in two patients and control groups. Also, AT genotype and TT genotype compared with AA genotype increased the chance of disease by 1379 and 3.5, respectively. In addition, TT alleles compared with AA alleles, increased the chance of osteoporosis up to 1.605 times.

Conclusion: Of course, more complementary studies considering other LRP4 gene subtypes with more individuals for better findings are needed.


Phenotypic and genotypic evaluation of biofilm formation in vancomycin-resistant Enterococcus isolates from cancer patients
Sadaf Ataei Alamdari, Mohammad Arjomandzadegan, Mona Nassaj Manizani, Azam Ahmadi,
Volume 29, Issue 1 (3-2026)
Abstract
Background and Aim: Vancomycin-resistant enterococci (VRE) are among the common causes of nosocomial infections, and their ability to form biofilms may contribute to increased antibiotic resistance. This study aimed to evaluate the biofilm-forming ability of VRE isolates and their antibiotic resistance patterns.

Materials and Methods: A total of 70 stool samples were collected from cancer patients. Suspected Enterococcus isolates were identified through biochemical tests including catalase test (negative), growth in 6.5% NaCl, positive PYR test, and bile esculin hydrolysis. In total, 22 Enterococcus isolates were confirmed and preserved for further analysis. Resistance to vancomycin was determined using the Broth microdilution according to CLSI guidelines. Biofilm formation was evaluated using the microtiter plate assay. The presence of biofilm-associated genes gelE and cylA was detected by polymerase chain reaction (PCR).

Findings:
The results showed that 68.2% of the isolates were capable of forming biofilm. Based on optical density in the microtiter plate assay, 27.2% were strong biofilm producers, 13.6% moderate, and 27.2% weak. Additionally, 31.8% of isolates were non-biofilm producers. PCR results revealed that among the 22 isolates, gelE and cylA genes were present in 77.3% and 63.6% of cases, respectively.

Conclusion:
Biofilm formation plays a significant role in enhancing antibiotic resistance in VRE isolates. Identification of biofilm-associated factors can be beneficial in designing effective therapeutic strategies against these bacteria.
Ethical consideration
The ethics approval letter is available with approval ID IR.ARAKMU.REC.1403.047 and approval date 15/11/2023.

Funding:
This research was funded by Arak university of medical sciences, Iran.
 
Page 1 from 1     

© 2026 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb