Journal of Arak University of Medical Sciences

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Effect of the Alcoholic Extract of Portulaca Oleracea on Renal Ischemia/Reperfusion Injury in Rats

Majid Askaripour, Syed Reza Fatemi Tabatabaei, Hossein Najafzadehvarzi, Foruzan Hosseini,
Volume 18, Issue 11 (2-2016)

Abstract

Background: Renal injury following ischemia - reperfusion (I/R) is still an unavoidable problem in many remedial and medical situations. Portulaca oleracea (PO) has been known for its anti-oxidative effects. Then, the present study aimed to investigate the effect of ethanolic extract of PO (EEPO) on the renal function and antioxidant status after induction of I/R injury in the rat kidney.

Materials and Methods: A total of 30 rats (Wistar) were divided into five groups (n = 6 each). Sham group: underwent laparotomy without I/R, EEPO group: EEPO administered 300 mg/kg then was operated like sham, I/R group: was underwent renal ischemia/reperfusion only, EEPO150+ I/R and AEPO300+ I/R groups: were administered PO 150 and 300 mg/kg then underwent I/R operation. PO extract was administered for 5 days in the relevant groups by gavage. Serum urea and creatinine (Scr), the level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and total antioxidant activity (TAA) were determined. Data were analyzed by ANOVA and post hoc LSD test. P values of 0.05 or less were considered statistically significant.

Results: Induction of I/R and pretreatment with PO extract, increased the level of superoxide dismutase (SOD) in comparison with sham group (p<0.05, p<0.001). There were no significant differences in the levels of MDA, GSH and TAA among different groups. On the other hand, the Scr and serum urea of the I/R and treated groups were elevated compared to the sham group (p<0.001).

Conclusion: Ethanolic extract of PO did not strongly affect the renal antioxidant status and could not prevent the renal injury following I/R.

Effect of Pilates and Vitamin D Supplementation on Quality of Life (QoL) and Mental Health of Overweight Men: A Randomized Clinical Trial

Nona Fazlollazadeh, Masoumeh Habibian, Babison Askari,
Volume 25, Issue 2 (June & July 2022)

Abstract

Background and Aim Evidence shows that vitamin D deficiency and obesity are associated with impaired physical and mental health. This study aims to investigate the effect of Pilates and vitamin D supplementation on quality of life and mental health of overweight men.
Methods & Materials This is a randomized clinical trial with a pre-test/post-test design. Fifty overweight men were selected by a convenience sampling method and were randomly divided into four groups of control, exercise, supplementation, and exercise+supplementation. The exercise and combined groups performed 8 weeks of Pilates at an intensity of 50-75% of heart rate reserve, three sessions per week. The supplementation and combined groups received 50,000 IU vitamin D capsule once per week. Assessment tools were the 36-item Short Form survey (SF-36) and the General Health Questionnaire (GHQ). The data were analyzed by paired t-test, one-way ANOVA and Kruskal-Wallis test. P˂0.05 was statistically significant.
Ethical Considerations This study was approved by the research ethics committee of Islamic Azad University, Babol Branch, Iran (Code: IR.IAU.BABOL.REC.1398.088).
Results Vitamin D status in subjects was lower than normal (<30 ng/mL) at baseline. Eight weeks of Pilates alone, vitamin D intake alone, and the combined intervention led to a significant increase in SF-36 (10.57%, 9.26% and 15.75%, respectively) and GHQ (12.66%, 10.72% and 17.90%, respectively). However, the effect of combined intervention was higher on the SF-36 (P<0.001) and GHQ (P<0.001) scores compared to two other interventions.
Conclusion It seems Pilates alone, vitamin D supplementation alone, and their combination can improve the quality of life and mental health in overweight people with vitamin D deficiency, where the combined intervention is more effective.

The Role of Hemostatic System and the Importance of Blood Coagulation in COVID-19: A Review Study

Fatemeh Mohammadi, Maryam Nikrou, Kimia Sadeghi, Farid Askarifard, Mohammad Sayyadi,
Volume 25, Issue 2 (June & July 2022)

Abstract

Background and Aim Coronavirus disease 2019 (COVID-19) is a respiratory disorder that can affect many body systems, including the hemostatic system. In this study, we aim to investigate the role of hemostatic system and the blood coagulation in COVID-19.
Methods & Materials In this review study, the articles were searched using the keywords COVID-19, Respiratory infection, and Coagulopathy in Google Scholar, PubMed, Google Springer and Science Direct databases.
Ethical Considerations Ethical principles in writing this article were observed in accordance with the guidelines of the National Ethics Committee and the Committee on Publication Ethics (COPE).
Results Many changes in the coagulation profile of infected patients were reported, including changes in the platelet count, fibrinogen/fibrin degradation product, D-Dimer, fibrinogen, prothrombin time, and activated partial thromboplastin time. With the increase in the number of patients with COVID-19, several studies found out the occurrence of thrombosis and coagulopathy in patients.
Conclusion Due to the increase in the occurrence of coagulation disorders in patients with COVID-19, the administration of anticoagulants is needed for their treatment; it can play an effective role in improving the prognosis of patients.

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