Showing 7 results for Ashtiyani
Saeid Changizi Ashtiyani , Saeid Khameneh, Hamid Salimi Khaligh ,
Volume 3, Issue 2 (Summer 2000)
Abstract
Arterial baroreflexes are the most important mechanism of cardiovascular system that can respond to rapid blood pressure changes during everyday activities. In this study we have assessed adaptive responses of carotid baroreflexes during isometric & dynamic exercise and compared the results with acute response during rest. The applied work loud in dynamic exercise was 100 watts and in isometric exercise it was 50% of calculated maximum force. Experiments were performed on 12 young male healthy sedentary volunteers aged between 21-28. This study was done in three exercises. In all three protocles, adaptation process during stimulation was assessed by studying of beat to beat R-R interval of ECG. In order to stimulate the carotid baroreceptors neck suction device Eckberg model was used and duration of stimulation was 10 seconds. ECG was taken carefully. Examination of adaptive process during stimulation showed maximal response achieved in resting state is statistically significant compared with that of isometric and dynamic exercise respectively (P<0.038, P<0.007). where as, comparison of adaptive response of rest state with isometric exercise and dynamic exercise was not statistically significant. There is no significant relation between maximal and adaptative response in dynamic and isometric exercises, although in general adaptative process in resting state compared with isometric and dynamic exercise was more pronounced. This observation confirmed that Vagal withdrawal with alimited degree of sympathic stimulation are challenged in this phenomenon. In other words the Sa response to vagal stimulation is related by sympathic stimulation.
Ali Zarei, Saeed Ashtiyani, Fatemeh Rasekh, Ali Asghar Mohamadi, Ayob Gabari,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Hyperlipidemia is an important risk factor for cardiovascular diseases. In this study, the effects of physalis alkekengi extract on the levels of cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL), and triglycerides (TG) were evaluated.
Materials and Methods: In this experimental study, fifty adult male Wistar strain rats were selected and divided into five groups of ten: Control group with a normal diet, control group with a high fat diet receiving interpritoneal injection of saline for 21 days, and treatment groups with fatty diets which received maximum (0.1 g/kg), moderate (0.2 g/kg), and minimum (0.4 g/kg) dose interpritoneal injections of the extract. After this period, blood sampling was done and the obtained results were analyzed through SPSS software.
Results: According to the obtained results, LDL and cholesterol concentrations decreased significantly (P<0.05), whereas HDL and TG plasma concentrations did not reveal any significant changes.
Conclusion: The findings of this study show that such changes are mainly due to the lycopene existing in the plant. Lycopene is a strong antioxidant which inhibits the production of LDL and presumably increases the excretories through releasing cholesterol therefore, it reduces blood cholesterol level and controls cholesterol synthesis.
Hoshang Nagafi, Saeed Changizi Ashtiyani, Saeed Khamene,
Volume 14, Issue 3 (7-2011)
Abstract
Arterial baroreceptors are located in the carotid and aortic arteries and play a pivotal role in rapid control of cardiovascular system. The purpose of this article is to review the effects of baroreceptors stimulation on heart rate at rest and during exercise and cerebral blood flow rate in young and middle aged male and female individuals. There is ample evidence indicating that the arterial baroreflex remains functional during exercise by readjustment which is in direct relation to the intensity of exercise. These adjustments might be done through somatosensory afferents from peripheral regions of the body, pathways obeying central command neurons, or vasopressin and oxytocin pathways that converge into the nucleus tractus solitarii (NTS). Cerebral blood flow autoregulation is a process by which cerebral blood flow is maintained at a fixed rate despite fluctuations in cerebral perfusion pressure. Similar to that in young individuals, this mechanism, despite fluctuations in baroreceptors sensitivity, stabilizes cerebral blood flow rate in a certain range in middle-aged individuals, although with aging the absolute cerebral blood flow rate decreases in both genders. In addition, it has also been shown that after termination of carotid baroreceptors stimulation, heart rate increases which is known as postvagal tachycardia (PVT). It seems that two components, adrenergic and non-adrenergic, are involved in PVT.
Saeed Changizi Ashtiyani, Ali Zarei, Mehrdad Shariati, Jabary, Hasan Ghasemi,
Volume 14, Issue 5 (11-2011)
Abstract
Background: Physalis Alkekengi is a perennial plant with a creeping and ryzumy stem belonging to the solanaceae family. This study investigates the possible effects of Physalis Alkekengi on plasma concentrations of some biochemical factors.
Materials and Methods: Fifty male Wistar rats weighing an average of 190 ± 5 g were divided into five groups of ten: Control group without receiving any substances, control group with 2.0 ml/dl administration of the solvent, and three experimental groups receiving 0.4 (maximum), 0.2 (medium), and 0.1 (minimum) g/kg intra-peritoneal (IP) injections of the drug. The intra-peritoneal (IP) injection of the drug was done for 14 days and after this period, for conducting lab tests, blood sampling was done and the results were analyzed through ANOVA and Tukey test.
Results: According to the results, protein and albumin plasma concentrations showed a significant increase (P<0.05) while creatinine plasma concentration, bilirubin, and urea nitrogen (BUN) did not reveal any significant changes.
Conclusion: This family of plants contains significant amounts of glucocorticoids, such compounds are likely to increase liver and plasma proteins. In addition, due to the presence of compounds, such as physaline, vitamin C, and albumin, this extract is likely to increase blood pressure and, eventually, increase glomerulic refinement and diuretic properties therefore, the absence of significant increases in plasma concentrations of the substances produced by metabolism in plasma seems reasonable
Ali Zarei, Mehrdad Shariati, Shahnaz Shekar Forosh , Saeid Ashtiyani, Fateme Rasekh,
Volume 15, Issue 7 (December 2012)
Abstract
Background:Noticing the side effects associated with chemical drugs, using natural medicinal plants has gained more prominence recently. Physalis alkekengi extract is a medicinal plant belonging to Solanaceae family which similar to most drugs used in traditional medicine, despite possessing a multitude of medicinal properties, has not received sufficient attention. The aim of the present study was to briefly review the effects of Physalis alkekengi extract on the concentration of thyroid hormones, blood cholesterol, some plasma biochemical factors, liver function, immune system, and sexual hormones. Due to the extensive usage of Physalis alkekengi extract in traditional medicine, determining its advantages and possible side effects is of great physiologic and pharmacologic significance. Physalis alkekengi extract due to the presence of such effective substances as alkaloids, lycopene, glucocorticoids, alcoholic agents, and a large amount of vitamin C as well as antioxidant properties can play a significant role in changes in body homeostasis. This study dealt with the function and effect of Physalis alkekengi extract on different body organs through using proper keywords and extensive online search through electronic databases and credible sources. The results of this mini-review showed that Physalis alkekengi extract can bring about various significant changes in different body organs that have not been properly recognized. Therefore, further and more extensive studies should be done on this plant.
Amin Mombeyni, Mehdi Bahmanzade, Abbas Sarami, Saeed Changizi-Ashtiyani, Mohammad Parastesh,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: Following physical activity in various tissues of the body, oxidative stress occurs and affects the antioxidant capacity and consequently the fertility of men negatively. The aim of this study was to investigate the effects of resistance training on oxidative stress and spermatogenesis quality.
Materials and Methods: 20 male rats of Sprague Dawley (weight 200-250, 4 months old) were randomly divided into two groups of resistance training and control group (n = 10). The exercise program included climbing a ladder by hanging the load to the tail for 8 weeks (5 days a week, 3 times 4 repetitions). During the program, the load gradually was increased, and in the last week, it reached to 200% of the animal body weight. After intervention, the mice were anesthetized in separate groups and testicular tissue was isolated to evaluate Malondialdehyde index as an oxidative stress marker and to determine antioxidant capacity by Frap method. Fixation, processing, cutting of testicular tissue and eventually coloring steps were examined by Hematoxylin and Eosin (H & E). The spermatogenesisqualitywas calculated based on Johnson method. The data were analyzed by independent t-test was used and significance level was considered p <0.05.
Findings: Increased Malondialdehyde levels were observed in the treatment group compared to control group (p =0.01). In the training group, the spermatogenesis quality was lower (p =0.013), the antioxidant capacity in the training group was significantly higher than the control group (p=0.83) and there isn’t any significant difference.
Conclusion: The findings indicate thatdue to increased oxidative stress, increasing resistance training may have negative effects on the quality of spermatogenesis and men's fertility. |
Saeed Changizi-Ashtiyani, Majid Ramezani, Hossein Poorcheraghi, Seyed Mohammad Afzali, Parand Pirouzi, Sina Atashi, Ali Zarei,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism.
Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study.
Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.
Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended.
Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases.
