Showing 31 results for Asemi
Shahin Ghasemi, Ali Chehreii, Ali Moghimi, Ali Ehsanabadi, Alireza Biganeh,
Volume 3, Issue 3 (Autumn 2000)
Abstract
Introduction: Meningitis is the inflamination of leptomeninges caused by the infectious and non infectious agents. The most common kinds of infectious meningitis include bacterial. Viral, fungal and mycobacterial meningitis. The three types of infectious meningitis are acute bacterial meningitis, aseptic meningitis and subacute to chronic meningitis which can be differentiated on the basis of CSF findings. Three fourth of the acute bacterial meningitis involve the persons below 15 years old. The etiologist cause of acute bacterial meningitis differs in various age groups. The most reliable criteria in diagnosis are laboratory and clinical findings. The permanent neurologic damages are the main complications that remain forever. Prognosis and mortality rate of meningitis depends on various factors , among which the main factors is the early diagnosis.
Methods and Cases: This is a cross-sectional study performed on 240 patients with meningitis in FIROOZABADi HOSPITAL from 1996 to 1998. Demographic information, about clinical and laboratorial findings have been collected.
Results: The male to female preponderance was 1:3. 81.3% patients had a previous history of headache, 94.4% had fever and 27.1% have defferent states of reduced alertness. 56.2% persons were diagnosed as having viral meningitis, 37% as bacterial meningitis and 6.8% as T.B. meningitis. The cases diagnosed with bacterial meningitis were influenced by the following bacteria in order: Pneumococus (44.9%), Meningococcus(26.5%), Staphylococcus aureus (12.2%), gram negative bacilli (10.3%) and Haemophilus influenza (6.1%). In 2.4% of cases CSF smear and culture were negative. The mortality rate among the patients was 8% and 8% of them developed consequences. The means of ESR duration had significant difference among various groups with different etiologies.
Discussion: In attention rate of similar studies in England and French were 24.2% and 56%. In attention to high prevalence of meningitis in our country, further greater complementary studies see to be necessary.
Reza Ghasemi-Khah , Abdolhossein Dalimi-Asl , Bijhan Hashemi-Malayeri ,
Volume 6, Issue 2 (Summer 2003)
Abstract
Introduction: Considering the importance of hydatid cyst and its pathophysiological effects on the human body, we attempt to propose a method for killing of hydatid cyst protoscoleces in vitro condition using low voltage direct electrical current.
Materials and Methods: After collecting hydatid cyst from infected organs of slaughtered animals, their protoscoleces were cultured in four separated media of hydatid consisting of uid, RPMI, normal saline and Tris buffer. The protoscoleces with the same media were transferred to an electrolysis device, and then various sets of electric current density were applied. For measuring the survival rate of protoscolcces, the same cells movement as well as Eosin staining were used as standard techniques.
Results: Our findings indicated that the survival rate of protoscoleces in hydatid fluid was dependent on the electric current density and the time of the applied current. In this regard, the highest survival rate of 86.3% was observed when electric current density of 42.96 mA/cm2 was applied for one minute; while the survival rate of 0% was observed when an electric current density of 63.5 mA/cm2 was applied for one minute. In the RPMI, normal saline and Tris buffer media, similar results were obtained.
Conclusion: Low voltage of direct current can be used in destroying of protoscoleces during surgery on different body organs without any injury to host tissue and any relapse of the infection.
Ali Ghazavi, Afsaneh Zarganjfar, Ghasem Mosayebi , Bahareh Ghasemi, Shima Ghazali,
Volume 6, Issue 4 (Winter 2003)
Abstract
Introduction: Preclampsia is a pregnancy-specific condition characterized by hypertention, proteinuria and generalized edema. The condition usually occurs in the third trimester and word wide is one of the most common causes of maternal mortality and morbidity. No study concerning the immunological etiology and pathogenesis of preclampsia has been done in Iran. The aim of this study was to evaluate the role of some immunological factors involved in the pathogenesis of preclampsia.
Materials and methods: This research was a clinical trial study. We measured C3, C4, IgG, IgA and IgM levels in 20 women with preclampsia, 20 normal pregnant women and 20 non-pregnant women matched for age, BMI, parity and gestational age. Seven patients had developed severe and thirteen mild preclampsia. After written informed consent was obtained, blood samples of subject group.
Collected serum collected was analyzed for immunological parameters by the single radial immunodiffusion (SRID) method of Mancini.
Results: C4 level was significantly decreased in women with severe preclampsia than in women with mild preclampsia and normal pregnancies, whereas C3 level did not differ between groups. IgG concentration was significantly higher in non-pregnant women than in women with preclampsia and normal pregnancies. There was a significant decrease in IgA concentration in normal pregnant women compared with non-pregnant women. There was a not significant difference between the IgM concentrations of both groups.
Conclusion: Our data show several changes in immunological factors in preclampsia which may contribute to the pathogenesis of the disorder in Iranian women.
Akram Ranjbar, Hajar Rajabian, Yhya Jand, Elahe Mirza Zadeh, Akram Esmaili , Sara Ghasemi Nejad , Ali Akbar Malekirad,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: Disturbance between production of free radicals and antioxidant defense is named oxidative stress. One of the main sources of free radicals is smoking that induce oxidative stress.
Materials and Methods: This is a cross sectional study in which questionnaires including information such as age, sex, education, history and number of smoking and history of special disease were filled. Case group were smokers (n=43) who were smoking at least 5 years and their mean age was 37.7 year. The control group was consisted of 43 nonsmokers which were matched for age and sex. They were evaluated for oxidative stress markers including thiobarbituric acid reactive substance (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total thiol (SH) groups and gammaglutamyl transferase (GGT) levels in blood.
Results: Results showed that induction of oxidative stress in smokers as revealed by decreased FRAP (1.89±0.03 vs 2.24±0.04, p=0.01) and plasma Sh groups (0.22±0.08 vs 0.81±0.48, p=0.01) in comparison to those of controls. The activity of GGT and level of LPO increased but were not significant . Also the correlation between history of smoking and oxidative stress was not significant.
Conclusion: It is concluded that smoking have decreased FRAP and SH groups which may put smokers at future consequences of oxidative stress. It seems that improving antioxidant system in smokers is effective.
Reza Shahmirzaei, Saeed Sadrnia, Hassan Solhi, Ali Ghasemi,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Positive electrocardiogram (ECG) changes in patients with unstable angina or non-ST elevation myocardial infarction are well known, but problem arises when no specific changes in ECG are identified. The aim of this study is to evaluate the prevalence of these changes in hospitalized patients at Amir Kabir Hospital of Arak. Materials and Methods: This study was a cross-sectional one that was conducted on 124 patients hospitalized at the heart emergency ward of Arak Amir Kabir Hospital with unstable angina and non-ST elevation myocardial infarction. ECG changes and serum cardiac enzyme levels were analyzed on admission and 12 hours after admission. Results: According to patients’ history and serum cardiac enzymes, 62 patients had undergone myocardial infarction without ST segment elevation, 98.4% of whom had ECG changes and 1.5% showed no ECG changes. Of the 60 patients, who had been hospitalized with unstable angina, 90% showed ECG changes and the rest 10% revealed no such changes. Conclusion: In comparison to other studies reporting that 50% of patients with unstable angina and non ST elevation myocardial infarction reveal no ECG changes, a high percentage of patients referring with a chest pain to the heart emergency ward of Amir Kabir Hospital, had no significant changes in their ECG and were not hospitalized.
Sedigheh Moghasemi, Saedeh Ziaei, Zainab Haidari,
Volume 14, Issue 1 (3-2011)
Abstract
Background: Sex life is one of the most important aspects of quality of life which is affected by a multitude of factors which can disrupt it. This study compares the effects of two different hormonal therapeutic regimens on sexual performance of postmenopausal women. Materials and Methods: In this randomized clinical trial, a total of 111 healthy postmenopausal women with no absolute contraindication for hormone replacement therapy (HRT) were divided into two groups that received GI-Tibolone 2.5mg/day (N=57) and GII-continuous conjugated estrogen (CE) 0.625mg/day plus medroxyprogestrone acetate (MPA) 2.5mg/day (N=54) for six months. At baseline and after 6 months of treatment, blood samples were collected for determining sexual hormones level. Sexual function was assessed by Female Sexual Function Index (FSFI). Data were analyzed using Spss 16. Results: Of all the participants, 45 women in the tibolone group and 32 women in HRT completed the study. Compared with the baseline values, the tibolone group significantly improved on all the six FSFI domains however, in the HRT group, just two of the six domains, lubrication and pain, got improved. The increase in mean total score and the score of each domain of FSFI except for satisfaction domain in the tibolone group was significantly greater than the HRT group (p<0.05). In the tibolone group, testosterone (p=0.003), FTI (p=0.002), and FEI (p=0.021) increased in comparison to the baseline, whereas SHBG decreased (p<0.001). In GII group, SHBG (p=0.001) significantly increased and tibolone was tolerated better than HRT. Conclusion: In post menopausal women, tibolone is more effective than HRT in improving sexual function scores, especially the desire, arousal, and orgasm domains. Its side effects are also much more acceptable.
Zatolah Asemi, Mohsen Taghizade, Mansore Samimi,
Volume 14, Issue 2 (5-2011)
Abstract
Background: There is inconsistent evidence indicating that serum Zn deficiency in pregnant women may adversely affect fetal growth. In order to survey this matter in Iran, a study was conducted with the aim of determining the association between serum Zn in pregnant women of Kashan and anthropometric factors of their neonates in 2008-2009.
Materials and Methods: In this eross-secrional study, of all the pregnant women referring to Naghavi Polyclinic of Kashan University of Medical Sciences, 128 women and their neonates were selected. Serum Zn concentration in 6-9 month pregnant women and anthropometric factors of their neonates (weight, height, and head circumference) were measured. Then the relationship between the prevalence of Zn deficiency and the neonates’ anthropometric factors was reported. T-test and stepwise multiple regression analysis were used for data analysis.
Results: Mean weight and height of the infants whose mothers had low serum Zn concentration (below normal) were 130.1g and 0.6 cm less than the infants whose mothers had high Zn concentrations. A significant positive correlation was found between birth size height of the neonates and serum Zn concentration of the mothers (P=0.02).
Conclusion: The results suggest that maternal serum zinc level affects neonates’ height.
Saeed Changizi Ashtiyani, Ali Zarei, Mehrdad Shariati, Jabary, Hasan Ghasemi,
Volume 14, Issue 5 (11-2011)
Abstract
Background: Physalis Alkekengi is a perennial plant with a creeping and ryzumy stem belonging to the solanaceae family. This study investigates the possible effects of Physalis Alkekengi on plasma concentrations of some biochemical factors.
Materials and Methods: Fifty male Wistar rats weighing an average of 190 ± 5 g were divided into five groups of ten: Control group without receiving any substances, control group with 2.0 ml/dl administration of the solvent, and three experimental groups receiving 0.4 (maximum), 0.2 (medium), and 0.1 (minimum) g/kg intra-peritoneal (IP) injections of the drug. The intra-peritoneal (IP) injection of the drug was done for 14 days and after this period, for conducting lab tests, blood sampling was done and the results were analyzed through ANOVA and Tukey test.
Results: According to the results, protein and albumin plasma concentrations showed a significant increase (P<0.05) while creatinine plasma concentration, bilirubin, and urea nitrogen (BUN) did not reveal any significant changes.
Conclusion: This family of plants contains significant amounts of glucocorticoids, such compounds are likely to increase liver and plasma proteins. In addition, due to the presence of compounds, such as physaline, vitamin C, and albumin, this extract is likely to increase blood pressure and, eventually, increase glomerulic refinement and diuretic properties therefore, the absence of significant increases in plasma concentrations of the substances produced by metabolism in plasma seems reasonable
Mohammad Narimani, Saeed Ariapooran, Abbas Abolghasemi, Batool Ahadi,
Volume 15, Issue 2 (June-July 2012)
Abstract
Background: Mindfulness and emotion regulation have important effects on the variables related to mental health in chemical weapons victims. The purpose of this study was to examine the effectiveness of mindfulness-based stress reduction and emotion regulation training on the affect and mood in chemical weapons victims. Materials and Methods: This interventional study was conducted with two experimental groups and a control group including 47 male chemical weapons victims with high scores on the General Health Questionnaire in Sardasht city, Iran, randomly selected and then assigned to mindfulness training, emotion regulation training, and control groups. Mindfulness-based stress reduction (MBSR) training was used with experimental group 1, emotion regulation (ER) training was implemented with experimental group 2, and the control group received no training. Data were gathered using the General Health Questionnaire, Positive and Negative Affect and Depression-Happiness scales. Analysis of variance with repeated measure was used for analyzing the data. Results: The results indicated that mindfulness-based stress reduction and emotion regulation training significantly increased positive affect and mood and decreased negative affect in chemical weapons victims. Conclusion: The results supported the effectiveness of mindfulness and emotion regulation training on affect and mood in chemical victims. Therefore, attention to the effectiveness of mindfulness and emotion regulation on variables related to mental health is important in chemical weapon victims.
Zatollah Asemi, Ashraf Khorrami, Mohsen Taghizadeh, Zahra Abedini, Ali Akbar Rashidi,
Volume 15, Issue 6 (November 2012)
Abstract
Background: Protein-energy malnutrition is regarded as one of the public health problems in developing countries as a result of poor feeding due to poverty. This study was conducted to compare protein quality of two samples of commercial weaning food, Cerelac (based on dry milk, wheat and banana containing probiotic Bifidobactriumlactis) and Ghoncheh (based on dry milk, wheat, and honey), in rats. Materials and Methods: This experimental study was conducted on 64 male rats aged 23 days in 8 groups under 8 diets, including 2 test diets (Cerelaccontaining probiotic Bifidobactriumlactis and Ghoncheh), 1 standard diet (casein), 1 basal diet (protein free) for true protein digestibility and apparent digestibility study, 2 test diets, 1 standard diet, and 1 basal diet for net protein ratio, protein efficiency ratio, and food efficiency ratio study. Results: The contents of true protein digestibility for casein, Cerelac, and Ghoncheh were 93.77, 84.23 and 89.82, respectively and the results were significant in all of the groups (p<0.001). The content of net protein ratio for casein, Cerelac, and Ghoncheh was 4.38, 4.1 and 3.17, respectively and the results were significantin all of the groups (p=0.009). The contents of protein efficiency ratio for casein, Cerelac, and Ghoncheh were 3.05, 2.59, and 2.01, respectively and the results were significant in all of the groups (p<0.001). Conclusion: The findings of this study indicated that the protein value of Cerelaccontaining Bifidobactriumlactis was higher than Ghoncheh.
Zeinab Moghadami Fard, Jamilleh Abolghasemi, Mohsen Asadi Lari, Mehdi Mohammadi, Mahmood Reza Gohari, Masoud Salehi,
Volume 15, Issue 8 (January 2013)
Abstract
Background: There are various factors effective in the appearance of metastasis that have been surveyed and recognized in different studies. However, the appearance of metastasis by determination of these factors cannot be predicted. One of the models used for the analysis of recurrent data and consideration of heterogeneity between patients is frailty model. Materials and Methods: In this survival study, 133 women with breast cancer were treated in Fayazbakhsh Hospital, Tehran, during 2005-2007. All patients were followed until April 2011. Frailty model was employed for the analysis of data and gamma frailty distribution was assumed with the average one and Ө variance. All statistical methods were run in R software. Results: Disease-free survival rates for 3 and 5 years were 0.78 and 0.72, respectively. During the follow-up period, the risk of metastasis was estimated to be 43%. Two factors were identified as the prognostic factors in the appearance of metastasis: tumor malignancy grade and the number of positive lymph nodes. Frailty variance was 4.27 (P=0.001). Conclusion: The significant variance of frailty component in the model indicates that patients who have identical explanatory variables face different levels of risk experiencing metastasis. Also, specific characteristics of the patients are important in the incidence of metastasis.
Zahra Salemi, Samane Kamali Pooya, Mojtaba Ghasemi,
Volume 16, Issue 3 (6-2013)
Abstract
Background: The hypothesis that non-secretor status of individuals makes them more susceptible to certain bacterial infections and they might be at a greater risk of metabolic syndromes and autoimmune diseases motivated us to evaluate the relationship between secretor status and risk factors for duodenal ulcer in the present study.
Materials and Methods: This case-control study was done on 120 patients with duodenal ulcer, gastric ulcer, and gastric cancer undergoing endoscopy, and a control group including 120 healthy individuals. Secretor status was determined by saliva and the association of some risk factors with the prevalence of disease was determined by a questionnaire. The results were analyzed by SPSS software version 16.
Results: Overall, 27.5% of the patients were non-secretor and 72.5% were secretor, whereas 20.8 % of the controls were non-secretor and 79.2% were secretor. There was not a significant relationship between secretor status and the incidence of gastrointestinal diseases. However, some risk factors, such as gender, smoking, and physical activity, were significantly associated with gastric disease.
Conclusion: The statistical analysis showed that there was not a significant association between secretor status and prevalence of gastric disease. According to the results, gastrointestinal diseases are more common in men than women and in smokers more than nonsmokers. Furthermore, physical activities reduce the incidence of this disease.
Anis Jahanbazi, Karim Asgari, Ahmad Chitsaz, Hosseinali Mehrabi, Neda Asemi,
Volume 16, Issue 6 (9-2013)
Abstract
Background: Focal dystonia is a chronic disease with unwanted side effects. In addition to physical symptoms, some psychological problems, particularly depression, anxiety and stress are common in patients with focal dystonia. The aim of this study was investigating the effectiveness of medication in comparison to medication plus EMG biofeedback on depression, anxiety and stress in females with chronic focal dystonia.
Materials and Methods: This was an experimental/interventional study with pre, post, and follow-up phases. The sample was consisted of 20 female patients with spasmodic torticollis and 10 patients with blepharospasm. All of the patients have been already diagnosed by neurologist They were randomly selected and assigned into medication and medication plus EMG biofeedback groups. Both of the groups were treated with botulinum toxin type A and the second group in addition to receiving the drug for 10 weeks also participated in 20 sessions of EMG biofeedback treatment. Data were collected through the DASS-42 questionnaire which was completed in the pre-test, post-test, and follow-up phases.
Results: The mean of DASS-42 score in the Medication plus EMG biofeedback group showed a significantly higher decrease compared to the medication group (p<0.05).
Conclusion: The results suggested that medication plus EMG was more effective than medication alone in decreasing depression, anxiety and stress in females with chronic focal dystonia.
Navid Mazruei Arani, Homa Baghaei, Ashraf Khorrami Rad, Zatollah Asemi, Sabiheosadat Alizadeh, Ahmad Esmaeilzadeh,
Volume 16, Issue 6 (9-2013)
Abstract
Background: Increased insulin resistance, inflammatory factors and parameters of oxidative stress are associated with the development of diabetes complications. This study was designed to determine the beneficial effects of synbiotic Gaz on insulin resistance, inflammatory factor and oxidative stress in patients with type 2 diabetes.
Materials and Methods: This randomized crossover double-blinded controlled clinical trial was performed among 62 diabetic patients aged 35-70 y. Subjects were randomly assigned to consume of either the synbiotic (n=62) or control Gaz (n=62) for 6 weeks. A 3-week washout period considered. The synbiotic Gaz was consisted of a probiotic viable and heat-resistance strain Lactobacillus sporogenes (1×107 CFU), 0.04 g inulin and 0.05 g stevia per 1 g as sweeteners' substances. Control Gaz (the same substance without probiotic bacteria and prebiotic inulin) was. Patients were received synbiotic and control foods in a 7 g package thrice a day. Fasting blood samples were taken at baseline and after 6-week intervention to measure insulin resistance, hs-CRP and biomarkers of oxidative stress.
Results: Consumption of synbiotic Gaz, compared with control, resulted in a significant decrease in serum insulin (p=0.02) and hs-CRP levels (p=0.008). Supplementation with synbiotic Gaz led also to a significant increase in plasma total glutathione (p<0.0001) compared to the control.
Conclusion: In conclusion, consumption of synbiotic Gaz for 6 weeks resulted in decreased levels of serum insulin, hs-CRP and increased levels of plasma total glutathione.
Pariya Karampoor, Mahnaz Azarnia, Ghadireh Mirabolghasemi, Farzane Alizadeh,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Fennel (Foeniculum vulgare) has estrogenic, anti-inflammatory and antioxidant effects and traditionally used for treatment of infertile women. Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in women, which affects 5-10% of them in their reproductive age. This study has examined the effects of hydroalcoholic extract of Fennel on female Wistar rats with PCOS.
Materials and Methods: In this experimental study, 30 rats (200 ± 20 gr), was injected 2 ml of estradiol valerate subcutaneously and 6 rats were considered as control(intact). After 60 days, the rats were divided into control, sham and experimental groups. Rats in experimental group were treated with 250, 500, 1000(mg/kg BW) of intraperitoneal injections extract of Fennel for 10 days. Serum FSH, LH and Testosterone were measured by ELISA and serum levels of these hormones between treatments all groups were compared using One-Way ANOVA at a significance level of p<0.05.
Results: The data suggests that extract of Fennel can increase serum concentrations of FSH and decrease LH and Testosterone in treatment groups. As FSH is 500 and 1000 mg/kg levels of doses, LH and Testosterone in dose 1000 mg/kg have shown statistically significant differences compared to control groups.
Conclusion: Considering the increasing positive effect of extract of Fennel on serum concentration of FSH and decreaseing LH and Testosterone in rats with PCOS, this compound might be considered for treatment of the patients.
Amir Abdollah Zangivand, Mahsa Ghasemi,
Volume 17, Issue 6 (9-2014)
Abstract
Background: Inflammation has an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the role of WBC (White Blood Cell) count and incidence of morbidity and mortality in patients with ACS.
Materials and Methods: This prospective study was carried out on 101 patients with ACS who admitted in Bu-ali Sina hospital. All patients were stratified according to WBC categories in to 3 groups, (WBC 1 :<7000 mm3, WBC 2:7000 -10000 mm3, WBC 3:> 10000 mm3). Demographic and laboratory data such as acute reactive protein, cardiac biomarker and etc. were recorded. Adverse cardiac events and mortality were recorded to a phone or in person for six months of follow up period. The collected data were analyzed using SPSS software (Statistical Package for Social Sciences, version 17.0). The Fisher´s exact chi-square test and the student t-test were applied. P-values less than 0.05 were considered significant.
Results: In our study, 5 patients (31.25%) in third group had recurrent non fatal cardiac event and the same percent (31.25%) were died after 6 months follow up. Multivariate analysis showed WBC count >10000 mm3 was strongest predictor of outcome in our patients.
Conclusion: WBC count can be considered one of the strong independent predictor of mortality and cardiac event in patients with ACS.
Maryam Kazemipoor, Afrooz Hajighasemi, Sanam Mirbeigi,
Volume 18, Issue 6 (9-2015)
Abstract
Background: Mandibular premolars, because of high anatomic variations, are among the most difficult teeth for root canal treatment.The aim of this study is to compare and evaluate root canal morphology of mandibular first premolars between males and famales in an Iranian population applying CBCT imaging.
Materials and Methods: In this analytical-cross sectional study, 230 CBCT imaging belonged to 115 males and 115 females were evaluated in this study. Images were assessed in the three spatial planes and the difference in the number of canals and roots were compared and reported statistically. Data were analyzed using SPSS 17 software and Chi-square test.The significance level was set as p<0.05.
Results: In total, of 460 mandibular first premolars, 85.7% had one root, 14.3% had two roots, 63.9% had one canal and 36/1% had two canals. In comparison between two genders, in the males the prevalence of one root was 78.7%, two roots 21.3%, one canal 60% and two canals 40%. In the females, the prevalence of one root was recorded as 92.6%, two roots 7.4%, one canal 67.8% and two canals 32.2%.
Conclusion: According to the results of this study the number of roots in the mandibular first premolars in males was statistically more than in females.
Fatemeh Alian Fini, Morteza Ghasemi,
Volume 19, Issue 4 (7-2016)
Abstract
Background: Mental health is an important aspect of health and the World Health Organization defines health as "full physical, mental and social welfare, and not merely the absence of disease". Given that 79 percent of the health education focused on physical aspects, in fact, the most focus is on biological parameters of people to measure their health. So we need a valid questionnaire to measure mentally and physically the health of people in the research community.
Materials and Methods: The Holistic Wellness Model reflects that the researches is done on health which is different in variant cultures perspectives.102 managers and officials of Islamic Azad University of Arak participated in this studyin 2014 and the validity and reliability of the questionnaire were analyzed using the software SPSS20.
Results: 102 people were enrolled in this study, 74 males (72.5%) and the rest were female. Cronbach' Alpha coefficient for the entire questionnaire was 0.93.In all six aspects which reviewed, the correlation between all questions and its perspective was measured by using Spearman test. There was a significant positive correlation among all the questions and the related aspects.
Conclusion: The Persian version of physical and mental health questionnaire, based on the Holistic Wellness Model, is suitable to assess the health of people. Also, validity and reliability is appropriate.
Fatemeh Hakimi, Najmeh Ranji, Mohammad Faezi Ghasemi,
Volume 19, Issue 7 (10-2016)
Abstract
Background: Pseudomonas aeruginosa is a major nosocomial pathogen that due to its intrinsic and acquired resistance to a wide spectrum of antibiotics poses a threat in clinical settings. One of the drug resistance mechanisms in P. aeruginosa is mutation in negative regulators of efflux pump systems such as nalC. The aim of this study was investigation of nalC mutations in P. aeruginosa isolates from some Rasht hospitals and Lahijan laboratories.
Materials and Methods: In this cross-sectional study, forty-five P. aeruginosa strains was isolated from several Rasht hospitals and Lahijan laboratories between 2013 to 2014 and identified by biochemical tests. The antibiotic resistance and susceptibility of isolates was determined by Kirby Bauer method and microdilution method. Then PCR-sequencing was carried out to assess nalC mutations in ciprofloxacin resistant isolates.
Results: In this study, the most P. aeruginosa strains was isolated from urine sample (53%), followed by burned strains (31%). The most resistance was seen to erythromycin (100%) and the lowest resistance was seen to ciprofloxacin (~31 %). The highest MIC of ciprofloxacin was determined in some strains >512 μg/ml. Sequencing results showed that 12 ciprofloxacin resistant isolates had one or several missense mutations G71E, S209R and E153Q in nalC gene.
Conclusion: Given that mutation was defined in most isolates in this study, it seems that mutation in nalC gene plays an important role in ciprofloxacin resistance of nosocomial P. aeruginosa isolates in Guilan province.
Mahtab Khosrofar, Mohammad Reza Pourreza, Samira Asgharzadeh, Parisa Tahmasebi, Elahe Ali Asgari, Reza Ghasemikhah, Nader Saki, Javad Mohammadi-Asl, Morteza Hashemzadeh Chaleshtori, Mohammad Amin Tabatabaiefar,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: Hearing loss (HL) is the most common congenital defect in humans. One or two in thousand newborn babies have prelingual hearing loss. Autosomal recessive non-syndromic hearing loss (ARNSHL) is the most common form of hereditary deafness. Hearing loss is more common in the developing countries which is due to genetic and environmental (cultural -health factors) reasons. HL has a wide range of clinical demonstrations including: congenital or late onset, conductive or sensory-neural, syndromic or non-syndromic hearing loss. The goal of this project is to determine the portion of the DFNB21 (TECTA) in ARNSHL in families with negative GJB2 gene in Khuzestan province.
Materials and Methods: We studied 21 families with ARNSHL with at least 4 patients and negative for GJB2 mutations from Khuzestan province. Genetic linkage analysis was performed using STR markers linked to DFNB21 locus.
Results: Following genetic linkage analysis and haplotyping, out of 21 families with ARNSHL, one family showed linkage to the DFNB21 (TECTA) locus.
Conclusion: The results of this project confirm other studies in Iran and give insight into the most common loci causing ARNSHL in Iran which could be helpful in research and clinic.
