Journal of Arak University of Medical Sciences

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Showing 5 results for Asadpour

Determination of Specific Activities of Radionuclides in Soil and Their Transfer Factor from Soil to Bean and Calculation of Cancer Risk for Bean Consumption in Iran

Reza Pourimani, Fariba Asadpour,
Volume 19, Issue 2 (5-2016)

Abstract

Background: Nuclear radiation emission by radionuclides causes the diseases, such as cancer or genetic anomalies. Therefore, the study of radioactivity in soil and food as well as calculating the risk of cancer seems essential for foods consumption.

Materials and Methods: In this research, nine different varieties of beans containing the grain of beans, areal part and their soil cultivated were collected. The specific activity of ²²⁶Ra, ²³²Th, ⁴⁰K and ¹³⁷Cs was determined for each sample employing gamma ray spectrometry method using high purity germanium detector with 30% relative efficiency.

Results: The absorbed dose rate in the air in one meter above the ground surface varied from 77.23 to 112.78 in nGy/h. The annual effective dose rate absorbed by adult person from the beans consumption in Iran is in the range of 122.14 to 905.86 in μSv/y. The cancer risk for the different varieties of beans varied from of 1.87 × 10^-5 to 1.59 ×10^-4 which is less than acceptable value as 10^-3.

Conclusion: The specific activities of radionuclides in soils samples are more than average of world wide range. The absorbed dose rate from bean consumption for the most of Varieties is more than of world average. Cancer risk resulted from bean consumption is less than acceptable value and consumption of bean has no risk for population health.

The Effect of Silybin Encapsulated in Nanoparticles on oprM Gene Expression in Drug Resistant Isolates of Pseudomonas Aeruginosa

Aref Mohammadipour, Najmeh Ranji, Leila Asadpour,
Volume 20, Issue 5 (8-2017)

Abstract

Abstract
Background: Pseudomonas aeruginosa is an opportunistic nosocomial pathogen that using several classes of antibiotics to treat has been led to the emergence of multiple drug resistance. One of the drug resistance mechanisms in Pseudomonas aeruginosa is overexpression of mexXY-oprM efflux pump system. Silybin as main flavonolignan of silymarin extracted from Silybum marianum is a hepatoprotective agent that its anti-bacterial properties was studied, recently. In this study, the effect of combination of silybin and ciprofloxacin on oprM gene expression in clinical isolates of Pseudomonas aeruginosa was evaluated.
Materials and Methods: In this study, seven ciprofloxacin resistant isolates of Pseudomonas aeruginosa were treated by ciprofloxacin (1/2MIC) only (control sample) and in the combination with silybin-encapsulated micelle (nanoparticles) (test sample). After 24h, RNA extraction and cDNA synthesis were performed in silybin treated and un-treated cells and oprM gene expression was quantitatively investigated by realtime PCR method.
Results: Results of this study showed that a silybin encapsulated in nanoparticles (400µg/ml) induces death up to 50% in resistant isolates treated by ciprofloxacin (1/2MIC) during 24h. Also, quantitative Real-Time PCR analysis revealed that silybin encapsulated in nanoparticles decreases the expression of oprM gene compared to silybin untreated cells.
Conclusion: It seems that Decrease of oprM expression in resistant isolates lead to decrease of mexAB-oprM and mexXY-oprM in cell surface, subsequently decrease of antibiotic withdrawal to extracellular environment and increase of sensitivity to antibiotics.

The Effectiveness of Emotionally Focused Couple Therapy on Sexual Self-Esteem and Sexual Function in Women with Multiple Sclerosis

Esmail Asadpour, Saeed Veisi,
Volume 20, Issue 7 (10-2017)

Abstract

Abstract
Background: The aim of this study was to investigate the effectiveness of emotionally focused couple therapy on sexual self-esteem and sexual function in women with multiple sclerosis in the city of Tehran.
Materials and Methods: This was a quasi experimental study with pretest-posttest, a month follow-up and control group. The statistical population included women with multiple sclerosis in the city of Tehran. 30 patients with the age range of 20-50 years old were chosen as samples and randomly were divided in 2 groups of individuals as control and emotionally focused therapy. The experimental groups practiced the emotionally focused therapy for a month, 9 step and 60 minutes in each session. Then, post-test was performed for them. For data collecting, the sexual self-esteem and sexual function questionnaires were used. Data analysis was done by using multivariate analysis of covariance by SPSS 23 software at a significant level less than 0.05.
Results: Statistical data analysis illustrated that the amounts of sexual self-esteem of life after emotionally focused couple therapy intervention were significantly increased in experimental than control group (p<0.05). Also, of emotionally focused therapy was significant increase on sexual function of women with multiple sclerosis (p<0.05).
Conclusion: According to the findings of this study, emotionally focused couple therapy has affected on sexual self-esteem and sexual function in women with multiple sclerosis Thus, emotionally focused couple therapy can be a good approach to improve the sexual problems in women with multiple sclerosis.

Investigation the Effect of Micelle Nanoparticles Containing Curcumin on Ciprofloxacin Resistant Isolates of Pseudomonas Aeruginosa and on mexC and mexD Genes Expression

Bozorgmehr Imani Pirsaraei, Najmeh Ranji, Leila Asadpour,
Volume 21, Issue 2 (5-2018)

Abstract

Abstract
Background: Pseudomonas aeruginosa is an opportunistic gram-negative bacterium that is a major cause of nosocomial infections such as severe burns. Curcumin is the main component of turmeric (Curcuma longa) that has anti-cancer and anti-inflammatory effects. The aim of this study was to evaluate antibacterial effect of curcumin in ciprofloxacin resistant isolates of Pseudomonas aeruginosa through mexC and mexD gene expression.
Materials and Methods: In this descriptive-analytical study, Pseudomonas aeruginosa strains were obtained from hospitals and laboratories in Guilan province. After disc difusion and MIC tests, four ciprofloxacin resistant strains of Pseudomonas aeruginosa were treated by ciprofloxacin (1/2MIC) only (control sample) and in the combination with curcumin encapsulated in micelle nanoparticles (test sample). After 24h, RNA extraction and cDNA synthesis was performed. Then, the expression of mexC and mexD genes was evaluated quantitatively by Real-time PCR method in curcumin treated and un-treated cells
Results: This study showed that combination of ciprofloxacin (1/2 MIC) with curcumin encapsulated in micelle nanoparticles led to approximately 50% of growth inhibition in Pseudomonas aeruginosa. In treated cells with curcumin and ciprofloxacin compared to treated cells with ciprofloxacin alone, mexC and mexD genes were significantly (p<0.05) downregulated >0.65 fold in three isolates and >0.1 fold in four isolates, respectively.
Conclusion: Our results suggested that curcumin encapsulated in micelle nanoparticles combined with 1/2 MIC value of ciprofloxacin inhibits the growth of Pseudomonas aeruginosa through reducing mexC and mexD expression.

The Effectiveness of Acceptance and Commitment Therapy on Marital Satisfaction, Sexual Self-Esteem and Burnout Martial among Women with Type 2 Diabetes

Esmail Asadpour, Saied Veisi,
Volume 21, Issue 7 (2-2019)

Abstract

Background and Aim: Marital and sexual problems of chronic patients, especially diabetes, that often are ignored, need special attention to proper treatment. The aim of this study was to investigate the effectiveness of acceptance and commitment therapy on marital satisfaction, sexual self-esteem and burnout martial among women with type 2 diabetes.
Materials and Methods: This study was a quasi-experimental research design with pretest-posttest and control group. The statistical population included women with type 2 diabetes in the city of Tehran. 30 patients were chosen as samples and randomly were divided into two groups of individuals as control and experimental. The experimental groups practiced the acceptance and commitment therapy 8 sessions and 60 minutes in each session. Then, post-test was performed for them. For data collecting, the marital satisfaction scale of Enrich (1993), sexual self-esteem scale of Doyle, Zeanah and Schwarz (1996) and burnout martial questionnaire of Pines (1993) were used. Data analysis was done by using multivariate analysis of multi covariance.
Ethical Considerations: This study with research ethics code IR.KHU.REC.1397.5 has been approved by research ethics committee at Kharazmi university of Tehran, Iran.
Findings: Results illustrated that after acceptance and commitment therapy, amounts of marital satisfaction and sexual self-esteem were significantly increased in experimental than control group (p<0.05). Also, acceptance and commitment therapy decreased burnout martial among women with type 2 diabetes significantly (p<0.05).
Conclusion: Acceptance and commitment therapy can be used as an effective psychological intervention on marital satisfaction, sexual self-esteem and burnout martial among women with type 2 diabetes.

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