Showing 12 results for Alipour
Ali Akbar Abdollahi, Bijhan Arya, Mohammad Jafar Gol Alipour, Mohammad Ali Vakili,
Volume 6, Issue 3 (Autumn 2003)
Abstract
Introduction: Pain is one of the main complaints of many postoperative patients. Narcotic and NSAID drugs are used to control postoperative pain.
Recent studies suggest different results of pain relief by NSAID group. We compared analgesic effects of intramucular Pethedine to Didofenac Sodium and Indomethacin suppositories due to inguinal hernioplasty.
Materials and Methods: This study was a clinical trial study over 55 patients of 17-60 years old who underWent unilateral inguinal hernioplasty.
These patients divided into 3 groups. The first group included 17 patients who received 100 mg Indomethacin suppository every 8 hours to relief postoperative pain. The second group of 18 patients who received 100 mg Diclofenac Sodium suppository every 8 hours and the third group induded 20 patients who received 0.5 mg/kg body weight Pethedine intramuscularly every 8 hours. The first dose of each drug started 2 hours after termination of operation. Tue sevrity of pain was checked by visual analogue scale method every 2 hours for 24 hours. Mean pain severity recoded and compared in 6 hours intervals.
Results: The averages of pain severity in the first 24 hours were 23±12 for Indomethacin, 31±9 for Pthedine and 27±12 hours for Diclofenac Sodium groups. There was no significant difference in whole 24 hours.
Conclusion: We concluded that Indomethacin and Diclofenac Sodium suppositories are good substitutes for intramuscular Pethedine to relief postoperation pain during the first postoperation day.
Ahmad Alipour, Seyed Mohammad Siadati,
Volume 9, Issue 4 (12-2006)
Abstract
Introduction:Final examinations are important stressors in schools and universities that result in different psychoneuroimmunological outcomes but the study of these effects on children has not been paid enough attention to. The aim of this study is to investigate the effect of final examinations on salivary immunoglubulin A in children. Materials and Methods: In this clinical trial a total of 100 children (50 boys, 50 girls) in 5th grade, aged less than 12 years from two primary schools of 5th educational district in Tehran were choosen randomly. The subjects completed Test Anxiety Scales of Sarason & Abolghasemi. After making sure of their physical and mental health by reviewing their medical history, clinical examinations and after controlling sleep, food, drug and sport variables, based on time series design, salivary IgA samples were taken five times as followed: one week before and then three times through mathematics, history and science exams and at last one week after passing the exams at, 9 to 10 am. IgA samples were analyzed by nephlometry method. Data was analyzed using ANOVA. Results: Findings indicated that IgA level was decreased significantly during examinations comparing to IgA levels before and after examinations (p=0.01). The relations of sex and anxiety scores were not statistically significant. It means that decreased IgA levels are the same in all children. Conclusion: Final examinations as a stress resource, diminishes IgA and this change is not related to sex and test anxiety score.
Nages Escandary, Zahra Alipour, Minoor Lamyian, Hoda Ahmaritehran, Ebrahim Hajizadeh, Somaieh Mokhah,
Volume 15, Issue 10 (March 2013)
Abstract
Background: International AIDS questionnaire allows for making cross-cultural comparisons between individual’s levels of awareness and attitudes towards AIDS. This study assessed the reliability and validity of international AIDS questionnaire for Iranian student population. Materials and Methods: In this cross-sectional study, 448 students studying in non-medical sciences at universities in Qom were selected through convenience sampling. The participants completed the international AIDS questionnaire–Persian version (IAQ-P). Confirmatory and explanatory factor analysis, Pearson correlation, and Cronbach's Alpha were used in order to examine construct and concurrent validities, respectively. Independent t-test was run to compare the questionnaire scores between male and female participants. Results: The CFA supported the four-factor model, and the normative data showed patterns similar to previous research. Four dimensions of the questionnaire data were satisfactory (AGFI=0.91, GFI=0.93 and RMSEA=0.04, P<0.001). The total IAQ-P had a high internal consistency (Cronbach’s alpha=0.80). Cronbach’s alphas for the sub-scales were 0.78 (myths), 0.78 (attitudes), 0.79 (personal risk), and 0.60 (facts). After one month, test-retest study on a sub-sample of 41 students revealed Pearson correlation coefficient ranges from 0.36 to 0.75 (P<0.001). Conclusion: The IAQ-P was shown to be a valid and reliable instrument and the results of this study are similar to other versions of IAQ in other languages.
Bagher Seyed Alipour, Najmeh Barimani, Abbasali Dehpour Jooybari, Seyed Mohammad Hoseini,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Nanomaterials have gained increasing attention because of their novel properties, including a large specific surface area and high reaction activity. This study was designed to investigate the cytotoxic effects of CuO nanopaticles on brain, spleen, and embryo NMRI pregnant mice.
Materials and Methods: In this experimental study, forty two female NMRI mice of (weighting 30±3.0 g) were randomly divided into six groups (four experimental groups, one sham group and one control group).The experimental mice on days 3 and 12 of pregnancy received CuO nanoparticle with concentrations 50, 100, 150, 200 mg/kg intraperitoneal injection. On day 17 pregnancy, brain, spleen and fetus weights were measured.Tissues for histopathological evaluation were stained with hematoxylin and eosin.
Results: Based on the macroscopic observations of embryos weight with increasing concentration of nanoparticle compared to control reduces its toxicity increased (p&le0.05). Spleen only at concentration of 600 mg/kg showed significant changes compared to control (p&le0.05). Histopathologic examination on brain and spleen following IP administration of CuO nanoparticle showed signs of cytotoxicity (congestion, necrosis, inflammatory cell infiltration, vacuolar degeneration) and (congestion, necrosis, increased hemosiderin) compared to control group, respectively.
Conclusion: The present study clearly showed that CuO-NPs can produce the histopathological abnormalities on brain and spleen tissues of NMRI mice in a dose-dependent manner.
Atefeh Biabangard Zak, Masoud Golalipour, Gholamreza Hadadchi, Alireza Abbaspour,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Due to the changing lifestyle in terms of nutrition and physical activity, obesity has become one of the major challenges to human health. The study of metabolic factors involved in this phenomenon plays an important role in preventing and treating the obesity. The aim of this study was to investigate the relationship between testosterone level and serum lipoproteins such as LDL and HDL with Body Mass Index (BMI), in different age groups of men in Golestan population.
Materials and Methods: In this case-control study, 183 men were randomly selected during 2012. Anthropometric measures (weight and height) were obtained according to standard methods, and BMI was calculated for each one. Data was analyzed using SPSS version 16. Pearson bivariate correlation test between groups and one-way Anova test was performed and p<0.05 being considered as significant.
Results: Data analysis showed a significant inverse correlation between BMI and serum testosterone level (p=0.005). In the study population, higher BMI was associated with increased LDL level (p=0.049) and also increasing age (p=0.011). In addition, an inverse relationship was observed between BMI and HDL levels that were not statistically significant (p=0.068).
Conclusion: The results of this study indicate that weight gain is associated with increased LDL and low testosterone serum level, and this relation is more meaningful in old men.
Begher Seyedalipour, Ali Hasani, Mohammad Ali Ebrahimzadeh, Mojtaba Mohseni,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Lamiaceae family has about 200 genuses and 4000 species. The majority of species of the family have essence that was used for nutritional, cosmetic and pharmaceutical industry. The aim of this study was to investigate the chemical composition of essential oil from aerial parts of Bollota platyloma and antibacterial activity of it.
Materials and Methods: In this experimental study, study Ballota platyloma, belonging to lamiaceae family and entomic of iran, was collected from Versk region in Mazandaran provinc. Essential oil from aerial parts was obtained by hydro distillation method by using Clevenger apparatus. GC/MS analysis of essential oil was carried out to identify major volatile constituents. Extraction was prepared by maceration method. Antibacterial activity of methanolic extracts against Pseudomonas aeruginosa, Bacillus subtilis, Stapylococcus aureus, Escherichia coli was investigated by disc diffusion method and minimal inhibitory concentration(MIC) method.
Results: Results showed that GC/MS analysis of the essential oil confirms the presence of 24 constituents in Ballota platyloma. The main constituents were Hexadecanoic Acid (40.03%), Germacrene D (26.6%) and Beta Caryophylene (4.76%). The results indicated that methanolic extract of Ballota platyloma possessed antibacterial activity. Among the aforementioned bacteria, the highest antibacterial activity was seen against S. aureus and the lowest activity against P. aeruginosa.
Conclusion: The findings of the present study showed that the major component of oil essential was germacrene-D and methanolic extract from the aerial parts of Ballota platyloma Rech. f. possess anti-bacterial effects. Thus, in order to find the underlying mechanism of this activity, further research should be carried out.
Homeyra Akbarzadeh, Abbas Alipour, Abolfazl Firuozian, Hadi Darvishi Khezri, Ghahraman Mahmoudi,
Volume 19, Issue 12 (3-2017)
Abstract
Abstract
Background: Ventilator-associated pneumonia (VAP) is one of the most important causes of mortality in intubated traumatic patients admitted in ICU. The aim of current study was to determine correlation between blood products transfusion with incidence of VAP in traumatic patients under mechanical ventilation in ICU.
Materials and Methods: This study was a prospective descriptive-analytical study. Current study was carried out on traumatic patients under mechanical ventilation admitted to Imam Khomeini hospital ICU wards of Sari city, from September 2015 to September 2016. In addition to demographic data, patients' clinical information were daily recorded.
Results: Of total of 2304 patients admitted to ICU, 186 traumatic patients under mechanical ventilation longer than 48 hours were reviewed and analyzed. Among patients infected with VAP, 36 persons(87.8%) had transfusion of blood products before VAP incidence. Blood products transfusion (before and / or after 48 hours) had the highest adjusted risk ratio in the incidence of VAP (Odds ratio; OR=3.58). Also, amount of injected Packed Red Blood Cells and platelet were significantly higher in patients infected with VAP (p<0.005).
Conclusion: Considering remarkable increase in incidence of VAP following blood products transfusion and its correlation with injected PRBC and platelet, considering these modifiable risk factors for controlling and preventing the incidence of VAP in traumatic patients under mechanical ventilation in ICU is necessary and reasonable.
Sanaz Alizadeh, Naser Aghdami, Bagher Seyed Alipour,
Volume 20, Issue 1 (4-2017)
Abstract
Abstract
Background: Copper nanoparticles (Cu NPs) induced angiogenesis, has been adapted to respond the most important challenging in wound healing. But due to the toxicity of nanoparticles, the nontoxic concentrations is important. The aim of this study was to determine the concentration and size of copper nanoparticles for investigating the effect of its cytotoxicity on the endothelial cell.
Materials and Methods: In this study, we exposed Cu NPs (40nm) with concentrations of 1, 10, 100 μM and 1 ,10 mM to endothelial cells and evaluate its viability effect after 24, 48 and 72 hours, according to the MTS) Methy Thiazol Tetrazolium (assay. Its optical density was determined using an ELISA reader and then was recorded.
Results: The findings demonstrated that Cu NPs was significantly (p<0.05) cytotoxic in concentration higher than 100 μM and cell viability was significantly increased following 48 and 72 hours in all concentrations, so that, the most difference was seen in 100 µM concentration. The IC50 values of Cu NPs at incubation time 24, 48 and 72 hours were 31.44, 36.67 and 29.38 μM.
Conclusion: The results showed that different concentration of Cu NPs in the 48 and 72 hours didn’t cause any cytotoxicity effect, but it stimulated endothelial cell proliferation. Therefore, Cu NPs with dose and time dependent effect has been increased endothelial cell proliferation.
Ali Asghar Ghorbanalipour, Pezhman Motamedi, Hamid Rajabi, Hadi Karami,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: The eNOS gene that is responsible for the production of nitric oxide and angiostatin is an inhibitor of angiogenesis. The aim of present study was to investigate the effect of endurance training on angiostatin and eNOS gene expression of cardiac tissue in type 2 diabetic male wistar rats.
Materials and Methods: In an experimental study, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (DET, n=12), Diabetic Control (DC, n=12) and Healthy Control (HC, n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 15 minutes in 1st week and reached to 27 m/min for 60 min/day in 9th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of angiostatin and eNOS were examined by Real-Time PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05.
Ethical Considerations: This study was approved in Research Ethics Committee of Arak university of medical sciences with the code IR.ARAKMU.REC.1394.329.
Findings: The gene expression of angiostatin and eNOS of DC group showed significant increase compared to HC group (p =0.000). The endurance training induced significant decrease in the gene expression of angiostatin and eNOS compared to DC group (p =0.000).
Conclusion: It appears that gene expression of angiostatin and eNOS of diabetic cardiac tissue are affected by positive effect of endurance training.
Mehrdad Nasrollahzadeh Sabet, Mohammad Foad Heidari, Mohammad Khanalipour, Saadat Allah Ghaffari, Milad Jafari Ashiani, Sajjad Biglari, Emran Esmaeilzadeh,
Volume 23, Issue 5 (December & January - Special Issue on COVID-19 2020)
Abstract
Background and Aim: Since late 2019, with the emergence of a new type of coronavirus that causes a new respiratory disease called COVID-19, there have been many concerns about the spread of this disease and how to deal with it. Due to the ability of the virus to be transmitted rapidly, diagnosing the infected individuals in the early stages for isolating them is critical. This study aims to evaluate the reliability of Computed Tomography (CT) scan in diagnosing COVID-19.
Methods & Materials: Participants were 212 patients admitted to hospital with confirmed diagnosis of COVID-19. Demographic information, medical history, symptoms, and the chest CT scan results were collected and analyzed. Finally, the power of CT scans in the diagnosis of this disease was compared with the Real-Time Polymerase Chain Reaction (RT-PCR) molecular test.
Ethical Considerations: This study received ethical approval from the ethics committee of AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091).
Results: The sensitivity of CT scan in the diagnosis of COVID-19 was relatively high, but its false-positive results were also high.
Conclusion: CT scan is a relatively sensitive method for diagnosing COVID-19, but caution should be made due to its high false-positive results which can lead to increased financial burden on the health system.
Mehrdad Nasrollahzadeh Sabet, Mohammad Khanalipour, Milad Gholami, Abdolazim Sarli, Arefeh Rahimi Khorrami, Emran Esmaeilzadeh,
Volume 23, Issue 5 (December & January - Special Issue on COVID-19 2020)
Abstract
Background and Aim: The new Coronavirus Disease 2019 (COVID-19) outbreak initiated from China in late December 2019, has posed a great global health threat. Since patients with high blood pressure, diabetes, and cardiovascular diseases are at high risk of COVID-19, this study aims to investigate the prevalence, severity, clinical manifestations, and mortality rate in COVID-19 patients with underlying diseases compared to those without underlying diseases.
Methods & Materials: This study was performed on 1408 patients with COVID-19 admitted to Golestan, Hajar, Khanevadeh and Besat hospitals in Tehran, Iran. Required data including disease prevalence, severity, clinical manifestations and mortality rate in patients with and without underlying diseases were collected and then analyzed using statistical tests in SPSS software, considering a significance level of P<0.05.
Ethical Considerations: This study was approved by the AJA University of Medical Sciences (Code: IR.AJAUMS.REC.1399.091). Ethical principles have been observed in accordance with the guidelines of the National Ethics Committee and the COPE regulations.
Results: Patients were 912 men (64.8%) and 496 women (35.2%) aged 18-98 years (Mean age= 57.8 years). Results reported that 27% of patients were intubated and 21.9% were died. Blood oxygen level in 53.7% of patients was less than 93 mg/dL; 36.1% had a history of hypertension, 24.1% had a history of diabetes, and 21.7% had a history of cardiovascular disease.
Conclusion: The severity, clinical manifestations, and mortality rate of COVID-19 patients with cardiovascular disease, diabetes and hypertension are significantly different compared to those without underlying diseases.
Arezoo Fathi, Ahmad Alipour, Aliakbar Malekirad,
Volume 26, Issue 2 (June & July 2023)
Abstract
Introduction: Infertility is one of the bitter events of married life that has various psychological consequences. On the other hand, there are different treatments to reduce its psychological effects. The purpose of this research was to compare the effectiveness of emotion-focused couple therapy and Gottman couple therapy on marital burnout and depression in infertile couples.
Methods: The present research method was semi-experimental with a pre-test-post-test design with a control group. The statistical population of this research included infertile couples of Arak city in 1400, of which 54 couples were selected using available sampling method and 18 couples were randomly assigned in three groups (two experimental groups and one control group). The experimental intervention groups received emotion-focused couple therapy (10 sessions of 90 minutes) and Gottman couple therapy (10 sessions of 90 minutes), and the control group did not receive any intervention. After two months, the follow-up phase was done. In order to collect data, Beck's (1967) depression questionnaire and Pines' (1966) marital burnout questionnaire were used, and the data were analyzed using repeated measures analysis of variance and SPSS version 26 software. This research is approved by the ethics committee with the code IR.IAU.B.REC.1400.026. Also, the principles of confidentiality, written informed consent and destruction of participants' information have been observed.
Results: The results showed that Gottman couple therapy and emotion-focused couple therapy reduce couples' depression (2 = 0.265, P = 0.001, F = 18.94) and marital burnout (2 = 0.348, P = 0.001, F = 27.99) has been effective. In addition, emotion-focused couple therapy has been more effective in reducing couples' depression (p=0.033) and marital burnout (P=0.001) than Gottman's couple therapy.
Conclusions: According to the results of the research, it can be said that emotion-focused couple therapy is more effective than Gottman's couple therapy in reducing couples' depression and marital exhaustion. Therefore, couple therapists are advised to use emotion-focused couple therapy to improve depression and marital burnout of infertile couples.
