Showing 17 results for Alaei
Nasrin Alaei,
Volume 1, Issue 1 (Winter 1996)
Abstract
This article has no abstract.
Afsaneh Talaei ,
Volume 6, Issue 3 (Autumn 2003)
Abstract
Introduction: POEMS is a rare systemic disease. This syndrome is usually associated with multiple mylom and skin changes. By now, it has been reported two cases of this disease in Iran.
Case: The patient was a 53 years old male who had history of hospitalization for recurrent pulmonary infections. Additionally, he had history of hyperthyroidism and idoide treatment. In the last presentation, he was hospitalized because of low back pain. Bone marrow aspiration findings showed that the cause of low back pain is multiple mylom. In abdominal computed tomagraphy, splenomegaly was cleared that all of these systemic findings are representatives of multiple mylom and POEMS syndrome.
Conclusion: In this study a POEMS syndrome patient that suffering from hyperthyroidism was introduced.
Afsane Talaei, Saber Jabari, Mohammad Hassan Bigdeli, Heidar Farahani,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: Diabetes is the most important metabolic disease in human. The prevalence of both types of diabetes is rapidly increasing ocross the world. Diabetes causes many complications including End Stage Renal Disease (ESRD). Diabetes is responsible for 30% of ESRD. The prevalence of diabetic nephropathy in Iran is also high. Many of these patients are becoming dialysis dependent. Many studies have shown the changes of trace metals’ levels in diabetic patients including Copper, Zinc, Manganese and Chromium. This study evaluates the correlation between urinary Copper and diabetic nephropathy Materials and Methods: This is a case-control study. Samples were selected among type 2 diabetic patients attending to diabetes clinic in Vali-e-Asr hospital in Arak. Diabetic patients were divided in two groups based on microalbuminuria, 42 patients in case and 40 patients in control group. Then the patients were classified based on duration of diabetes into 4 groups and based on the HbA1c into two groups. Then urinary Copper was determined with atomic absorption spectophotometry and compared. Independent t-test was used to analyze data. Results: Patients were 28.1% male and 69.9% female in case group and 37.5% male and 62.5% female in control group. The mean Copper level was 36.14µg /L (14.54-57.74) in case group and 14.77% µg /L (10.17-19.37) in control group. There was a statistically significant difference between the two groups (p=0.003). Conclusion: The results show a positive relation between urinary Copper and diabetic nephropathy and confirmed the results of other studies that reported the elevation of Copper in microalbuminuria. This study also showed that age, gender, duration of diabetes and HbA1c level have no effect on urinary Copper.
Zahra Adgi, Afsaneh Talaei, Mahnaz Mohamadi Kelishadi,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Hirsutism in women is identified as the increasing growth of terminal hair in areas of skin that are sensitive to androgen. The most common causes of hirsutism are PCOS (polycystic ovary syndrome) and idiopathic hirsutism. The role of insulin resistance and hyperinsulinemia as the most important pathogenesis mechanism of PCO is quite obvious, but there is not enough information on the role of insulin resistance in idiopathic hirsutism.
Materials and Methods: This cross-sectional study was conducted on 16 to 40 year old women. Medical history and physical examination were completed for patients with PCOS and idiopathic hirsutism. Hormonal tests and sonography were run for both groups and insulin resistance was assessed using HOMA-IR formula. Data were analyzed using SPSS version. 17.
Results: Mean of serum insulin levels in PCOS and idiopathic hirsutism groups were 16.04±1.4 and 7.32±6.85 µIu/ml, respectively (P<0.001). HOMA-IR values in PCOS and idiopathic hirsutism groups were 3.7± 3.36 and 1.67±1.75, respectively (P< 0.001). Mean of serum DHEA-S levels in PCOS and idiopathic hirsutism groups were 2.48±1 and 1.84±0.46 pg/ml, respectively (P< 0.001). These findings indicated a significant difference between the two groups. However, in terms of serum glucose, testosterone, androstendione, and follicular hormones levels, there were not any significant differences between the two groups.
Conclusion: In both PCOS and idiopathic groups, there was a significant relationship between hirsutism and insulin resistance. This relationship, however, was more significant the PCOS group
Mahnaz Edalat-Nejad, Fatemeh Zameni, Afsaneh Talaeie,
Volume 14, Issue 4 (9-2011)
Abstract
Background: Recent studies have shown that nicotinic-amide and niacin induce significant reductions in serum phosphorous in patients undergoing hemo-dialysis. The aim of the present study was to determine the effect of nicotinic acid on serum phosphorous level in patients undergoing long-term hemodialysis.
Materials and Methods: In an 8-week cross-over randomized double-blind clinical trial, 37 patients were assigned to nicotinic acid or placebo groups with titration from 400 to 1000 mg/ daily. A 2-week washout preceded the switch from nicotinic acid to placebo or vice versa. Statistical analysis was performed using paired- sample t test.
Results: The mean dose of nicotinic acid at the end of the period was 740±204 mg/daily. Nicotinic acid showed a significant decrease in serum phosphorus after the 8-weeks treatment however no significant changes occurred in the placebo group (P =0.01). Also, nicotinic acid resulted in an increase of HDL cholesterol levels after 8 weeks.
Conclusion: Nicotinic acid can lead to a decrease and an increase in serum phosphorous and HDL cholesterol levels, respectively. However, there is need for longer trials with larger sample sizes for determining the most effective doses of this drug.
Afsaneh Talaei, Mahnaz Mohamadi Kelishadi, Zahra Adgi,
Volume 14, Issue 5 (11-2011)
Abstract
Background: Different studies have shown that vitamin D may play a functional role in insulin secretion and sensitivity. This study evaluates the effect of vitamin D on insulin resistance.
Materials and Methods: This clinical trial was done on 100 patients with type II diabetes mellitus that aged 30-70 years. The patients were randomly selected and different examinations were done on them. They received 50000 units of oral vitamin D daily for four weeks. Insulin resistance was measured before and after the intervention. Data analysis was done by paired t-test and Wilcoxon test using SPSS software version 17.
Results: The participants consisted of 70 women and 30 men. Mean vitamin D was 43.03±19.28 ng/ml and 24% of the participants were vitamin D deficient based on the cut-off 25(OH) D <20 ng/ml. At the beginning and the end of the study, the mean levels for FPG, insulin, HOMA-IR were 138.48±36.74 and 131.02±39 mg/dl (P=0.05), 10.76±9.46 and 8.6±8.25 µIu/ml (P= 0.02), and 3.57±3.18 and 2.89±3.28 (P= 0.008), respectively.
Conclusion: The findings of this study showed that vitamin D causes significant improvements in FPG, insulin, and insulin resistance, that was evaluated by HOMA-IR. It was also indicated that adding vitamin D supplements can improve glucose control in type II diabetes mellitus.
Mostafa Hosseini, Rahman Ghafari, Sima Karbalaei Esmaeili,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Monitoring of facial nerve function during surgery help surgeons to preserve the nerve during parotid gland surgery. EMG is currently the standard method for monitoring, however, the rates of facial nerve paresis and paralyses are 68-18% and 3%, respectively. The disadvantages of this method are its cost and lack of access to it everywhere. Unipolar alternating electric current stimulation of the facial nerve causes contraction of the muscles and the nerves, and the damage can be avoided.
Materials and Methods: In this study, patients in the years 1388 to 1390 using monopolar electrocautery was undergoing parotidectomy and one month after surgery, the facial nerve injury were examined. During the study period, twenty patients had undergone total or superficial parotid gland resection and one excluded due to facial nerve involvement before surgery.
Results: In this study, 19 patients were studied. The mean age of patients participating in this study, 43.1 ± 13.9 years and 63.2% of them (12 cases) were female. A temporary palsy (5.4%) was observed and there was no paralysis.
Conclusion: Due to its availability and low cost, using electrocautery devices compared with standard facial nerve monitoring, EMG, is beneficial and the treatment results are also satisfactory.
Sayyed Alireza Talaei, Mahmoud Salami, Sayyed Mojtaba Banitaba,
Volume 17, Issue 7 (10-2014)
Abstract
Background: Environmental signals have a crucial role in development of brain’s structure and function during critical period of brain development. Gt was valuated the devebpmental effeck in developmental effect of visual deprivation on synaptic plasticity of Dentate Gyrus neurons was evaluated.
Materials and Methods: This experimental study was carried on 2 groups (n=48) rats kept in standard 12-hour light/dark condition (Light Reared-LR) or in complete darkness (Dark Reared-DR) since birth throughout the study. Each group, in turn, was divided into 3 groups of 2, 6 and 10 weeks old subgroup (n=8 for each). Stimulating the perforant path, field potentials were recorded in the Dentate Gyrus area for 30 minutes. Then, the tetanic stimulation was applied to the Schaffer collaterals and the field potentials were pooled for 120 minutes post-tetanus in all animals.
Results: The basic responses of the LR animals decreased and the amplitude of the DR rats increased, across aging. After the LTP induction, amplitude of responses increased in all groups but the amount and stability of them were lower dark reared in animals than the LR ones.
Conclusion: Change in environmental visual signals impairs basic response and LTP induction in neurons of Dentate Gyrus area of hippocampus.
Ahmad Hamta, Maryam Yousefi, Masood Fazeli Mosleh Abadi, Afsaneh Talaei, Abdorrahim Sadeghi,
Volume 18, Issue 9 (12-2015)
Abstract
Background: Thyroid nodules are common. 4-7% of adults have a palpable nodule and up to 50-70% of nodules are detected in high-resolution sonography. Thyroid nodules in women are 4 times greater than men and the rate of thyroid cancer in women is 3:1 compared to men, and is the sixth most common cancer in women. Epidemiological findings and experimental evidences show that sex hormones, especially estrogen, may have effect on this gland and its neoplasm. The aim of this study was to investigate the association between rs1256049 polymorphism in the estrogen receptor beta gene with thyroid nodular disease.
Materials and Methods: In this case-control study, 146 Patients with nodular thyroid and 151 health individuals were referred to Amiralmomenin hospital of Arak were recruited in study. Diagnosis is based on by ultrasonography and was confirmed by an endocrinologist. Genomic DNA was extracted from EDTA treated whole blood .The genotypes were determined using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) and analyzed by statistical methods.
Results: The frequency of CC, TC and TT genotypes in case group 136(93.2%), 10(6.8%) and 0(0%) and in the control group 139(92.1%), 12(7.9%) and 0(0%) were obtained respectively. No statistically significant association (p=0.72) was observed between nodular thyroid disease and rs1256049 polymorphism.
Conclusion: Our findings showed no significant association between rs1256049 polymorphism and nodular thyroid disease. For best deduction, it is recommended that this study be done in other populations.
Sanaz Mahdipour, Samaneh Teimouri, Omid Reza Tamtaji, Mojgan Mohammadifar, Mohsen Taghizadeh, Sayyed Alireza Talaei,
Volume 20, Issue 2 (5-2017)
Abstract
Background: Neuropathic pain is a chronic pain that affects on the patient’s quality of life. Use of herbal instead of synthetic drugs recently has been increased due to side effects of synthetic drugs and herbal effective components. Flavonoids are herbal compounds that have analgesic and anti-inflammatory effects. Because Allium cepa L. has a great amount of flavonoids, this study has been designed to evaluate analgesic effects of alcoholic extract of Allium cepa L. on neuropathic pain behavior in chronic constriction injury model in rats.
Materials and Methods: In this experimental study, neuropathic pain induced by chronic constriction injury (CCI model) in Rats. Animals were randomly divided into 4 groups (n=10 for each): Sham, CCI model, receiving red onion hydroalcoholic extract at a dose of 100 mg/kg and a group receiving gabapentin (100 mg/kg). Red onion extract and gabapentin were administered by gavage for 21 days. Using thermal hyperalgesia, mechanical and thermal allodynia tests, the analgesic effects of extract have been measured.
Results: Findings of this study revealed that CCI surgery on rats induced hyperalgesia, mechanical and thermal allodynia. Daily intakes of alcoholic extract of red onion and gabapentin significantly increase the paw withdrawal latency; increase the threshold to mechanical allodynia and decrease in response to acetone.
Conclusion: Oral use of alcoholic extract of Allium cepa L. reduces neuropathic pain behavior in CCI model in rats.
Majid Amiri Motlagh, Mohammad Ali Atlasi, Zeinab Vahidinia, Sayyed Alireza Talaei, Zeinab Rezazadeh Lavaf, Abolfazl Azami Tameh,
Volume 20, Issue 5 (8-2017)
Abstract
Abstract
Background: Glutamate is the most widespread excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays major role in the pathogenesis of ischemia brain injury.Glutamate transporters have a major role in glutamate removal and maintain its concentration below excitotoxic levels. Although estrogen’s and progesterone’s neuroprotective effects were well-described, the exact molecular mechanism has yet to be determined. This study has investigated estrogen and progesterone effect on glutamate transporters expression in the ischemic penumbra/peri-infarct region in rat.
Materials and Methods: Adult male Wistar rats were subjected to transient middle cerebral artery occlusion (tMCAO) for 1 h. Estrogen and progesterone combination was immediately injected after tMCAO subcutaneously. Sensorimotor functional tests for evaluating behavioral deficits and TTC staining for measurement of infarct volume were performed 24 h after MCAO. Real-time PCR technique was used for gene expression analysis of glutamate transporters EAAT2 and EAAT3.
Results: The combination of estrogen and progesterone could significantly reduce lesion volume. Also, hormone therapy could improve ischemic neurological disorders. After hormone therapy, gene expression of glutamate transporters EAAT2 and EAAT3 did not show significant changes.
Conclusion: Combined estrogen–progesterone treatment significantly reduces neurological deficits and infarct volume; these effects are independent of the glutamate transporters signaling pathways.
Afsaneh Talaei, Mehdi Mahmoudpoor, Maryam Shahdost,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: Regarding to paradoxical results of the studies about the effects of atorvastatin on inflammatory markers and metabolism, we aimed to evaluate the effects of atorvastatin on inflammatory markers in diabetic patients.
Materials and Methods: Through a double blind randomized clinical trial, placebo control, 88 type two diabetic patients (T2DP), were treated with anti-diabetes oral agents, were randomly classified into two 44 cases groups. The intervention group took atorvastatin 40 mg daily and control group took placebo for three months and adiponectin, hsCRP, leptin, TNF-α, lipid profile and fasting blood glucose (FBS) were measured and compared at the beginning and the end of the study. The data were analyzed using student t test and paired t test.
Findings: After three months, adiponectin was significantly increased in intervention group in comparison to control group, but leptin had not a significant change in two groups. Total cholesterol, hsCRP and LDL cholesterol (Low density Lipoprotein) were decreased significantly in the intervention group than control group, while FBS was
non-significantly decreased.
Conclusion: It seems atorvastatin is effective to decrease inflammatopry markers in diabetic patients.
Farzaneh Fuladi Targhi, Fardin Faraji, Ali Akbar Maleki Rad, Keyvan Ghassami, Afsoon Talaei,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Multiple Sclerosis is (MS) is a common demyelinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. The aim of the present study was to determine the anti-inflammatory effects of Melatonin on fatigue in MS.
Materials and Methods: In a double-blind clinical trials study, 62 patients with relapsing remitting MS were randomized to oral Melatonin 3 mg or placebo daily for 8 weeks. Scale of Fatigue in MS was studied by assessing FSS (Fatigue Severity Scale) on weeks 1 and 8.
Findings: 47 patients in intervention group and 15 patients in placebo group completed the study. In intervention group, treatment with Melatonin produced a significant decrease in FSS vs placebo group (before intervention: the average of FSS in patient group was 32.04±13.97 and in control group was 35.86±15.44; after intervention: the average of FSS in patient group was 30.42±12.40 and in control group was 41±12.66). Although in control group, the average of FSS was 35.866 and it was 41 after intervention. Because the score of placebo patient is near or upper than 36, this study suggested that Melatonin has a significant effect on improving and decreasing fatigue in MS.
Conclusion: The use of melatonin alongside of First-line drugs such as mitoxantrone, IFN – B or glatimer acetate can improve fatigue and disability in patient with MS.
Afsaneh Talaei, Mehdi Mahmudpour, Maryam Shahdost,
Volume 22, Issue 2 (6-2019)
Abstract
Background and Aim: Regarding the controversy about the effects of atorvastatin on blood glucose control and diabetes, we evaluated the effects of atorvastatin on blood glucose and insulin resistance in the present study.
Materials and Methods: 88 type two diabetic patients (T2DP), were treated with anti-diabetes oral agents were enrolled in a double blind randomized clinical trial, placebo control. Then they were randomly classified into two 44 cases groups. The intervention group took atorvastatin 40 mg daily and control group took placebo for three months and fasting blood glucose (FBS), insulin resistance, HbA1c and lipid profile were measured and compared at the beginning and the end of the study. Data were analyzed using student t-test and paired t-test.
Ethical Considerations: This study with research ethics code IR.ARAKMU.REC.90.108.10 has been approved by research ethics committee at Arak University of Medical Sciences.
Findings: After three months, insulin, insulin resistance and HbA1c decreased significantly in the intervention group than control group, while FBS non-significantly decreased. Total cholesterol and LDL cholesterol (Low density Lipoprotein) were also decreased.
Conclusion: It seems atorvastatin is effective to decrease FBS and insulin resistance in diabetic patients.
Zahra Shiravand, Afsaneh Talaei,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Thyroid diseases are among the most common endocrine disorders. Animal and human experiences indicate that iron deficiency disrupts thyroid metabolism. On the other hand, iron therapy can improve thyroid function and even decrease the dose of levothyroxine.
Methods and Materials In this randomized clinical trial, we selected 94 women with hypothyroidism by simple random sampling method and divided them into two equal groups by simple block sampling. At the beginning of the study, we measured and recorded T4, TSH, T3, and iron profiles (Serum iron, total iron-binding capacity, ferritin, Hemoglobin) in all patients. Then, the patients in the intervention group were treated with levothyroxine plus 100 mg oral iron daily for 8 weeks, and the patients in the control group were treated with levothyroxine only. After two months, we measured their T4, TSH, T3 levels and iron profiles in both groups again.
Ethical Considerations The Research Ethics Committee of Arak University of Medical Sciences approved this study (Research Ethics Code: 1396154). Also, the study has been registered at the Iranian Registry of Clinical Trials (Code: IRCT 20151114025031).
Results After 2 months, the TSH Mean±SD serum levels were found as 2.2±1.0 mIU/L and 2.9±1.1 mIU/L for the intervention and control group, respectively (P=0.04). Also, the serum Mean±SD level of T4 and T3 were found as 9.3±1.48 mcg/dL vs. 8.2±0.9 mcg/dL (P=0.01), and 1.6±0.3 ng/mL vs. 1.1±0.3 ng/mL (P=0.01), for two different groups, respectively.
Conclusion Concurrent administration of iron supplementation with the usual dose of levothyroxine in patients with hypothyroidism decreases THS level and improves laboratory parameters and response to treatment.
Mahbobeh Karbalaei, Jahangir Karami, Parvaneh Karimi,
Volume 24, Issue 5 (December & January 2021)
Abstract
Background and Aim: The type of circadian rhythms is essential in maintaining physical and mental health and recovery from the disease. This study aimed to investigate the role of circadian rhythms on sleep quality and corona anxiety in men and women.
Methods & Materials: The present study is a descriptive comparative causal description. The statistical population included all 18-50 who participated in the survey online. People who completed the questionnaire online were selected for sampling. The research instruments included the circadian inventory rhythms Horne and Ostberg (1976), Petersburg Quality of Sleep Questionnaire (1989), and Alipour et al.’s (2020) Corona-related Anxiety Scale in the Iranian sample. Multivariate analysis of variance (MANOVA) and the Scheffe test were used to analyze the data.
Ethical Considerations: This study was registered with the Ethics Committee Razi University Technology Units Development Center at Institute for Psychoanalytic Studies (No.: 99133).
Results: The results showed that the mean of mental and corona physical anxiety in women and men with evening type is higher than in other classes. Men and women in the evening type have a lower sleep quality than in the morning and middle types. The results also showed significant differences between the types regarding corona anxiety, sleep quality, and sex. The difference between the mean of the morning type and evening types’ mean was more than other differences between the means.
Conclusion: Individual differences in morning-evening types seem to play an essential role in the quality of sleep and the experience of corona anxiety
Dr Afsaneh Talaei, Afsaneh Talaei,
Volume 28, Issue 2 (4-2025)
Abstract
Thyroid nodules are a common clinical finding. Recent attention has been drawn to the role of insulin resistance in their development. While several studies have explored the link between metformin and insulin resistance, fewer have assessed its effects on thyroid nodules.
This study examines the impact of metformin on thyroid nodule size and thyroid hormone levels.
The present study evaluate the effects of metformin on thyroid nodule size and thyroid hormones levels.
Methods:
A total of 240 euthyroid women with thyroid nodules were divided into four groups. Group 1 received 100 mcg of levothyroxine daily, Group 2 received metformin 500 mg twice daily, Group 3 received a combination of both drugs for three months, and Group 4 served as the control group with no treatment. Thyroid ultrasound was performed at baseline and after three months. Statistical analyses included the Kruskall–Wallis, Wilcoxon, and Chi-square tests, examined the differences of the size of thyroid nodules and the mean of thyroid hormones levels between groups, for each group and to compare the percentage of differences between the groups, respectively. Also P value less than 0.05 was considered meaningful.
Results:
Kruskall–Wallis test revealed no significant differences in thyroid hormone levels between the groups after treatment, except in the levothyroxine group. Wilcoxon test showed significant reductions in TSH and increases in T4 levels within the levothyroxine group. Additionally, thyroid nodule size significantly decreased in the levothyroxine and combination therapy groups, while metformin alone had no significant effect on the size of thyroid nodules.
Conclusion:
Metformin alone does not appear to reduce thyroid nodule size. Future studies with larger sample sizes and extended durations are necessary to validate these findings and further explore metformin’s role in thyroid nodule management.
