Showing 5 results for Afshari
Morteza Behnam Rassouli, Nargess Ghayour, Majid Afsharian, Maryam Tehranipour, Mohammad Bagher Ghayour,
Volume 13, Issue 1 (4-2010)
Abstract
Background: Oxidative stress is one of the probable molecular mechanisms involved in lead (Pb) neurotoxicity. On the other hand, lemon balm (Melissa officinalis) which is widely used in traditional medicine, has a high antioxidant activity. In this study, the protective impacts of Melissa officinalis on the adverse effects of Pb toxicity on learning ability were investigated. Materials and Methods: In this experimental-clinical trial, 40 virgin Wistar rats were mated and divided into control, control positive (vitamin C+Pb), control negative (Pb), and 3 Pb and Mellisa experimental groups. Mellisa was orally administered in three doses including + 25, 50 and 100 mg/ kg of body weight daily. Treatment started from 7th day of gestation and continued through pregnancy and lactation periods. The three month- old offsprings in each group were assessed in terms of memory and learning ability by Morris water maze test and the results were compared between the groups. Results: Exposure to Pb during and after gestation leads to learning disorders. While concomitant administration of Pb and Melissa, as well as vitamin C can, to a large degree, reduce the adverse effects of Pb on learning abilities. Conclusion: Since no significant differences were obtained from the comparison of results in the control, Pb+M and vitamin C+Pb groups, it can be concluded that Melissa has antioxidant impacts equal to vitamin C. Therefore, similar to vitamin C, Mellisa can decrease the neurotoxic effects of Pb.
Masoume Afshari, Hamid Taher Neshat Doost, Fatemeh Bahrami, Hamid Afshar,
Volume 13, Issue 1 (4-2010)
Abstract
Background: This study was designed to investigate on efficacy of metacognitive–behavioral therapy (MCBT) on panic beliefs of panic female patients. Materials and Methods: This is a clinical- trial study. The participants, who were 24 panic female patients diagnosed with panic disorder, were selected from 76 panic patients referring to psychiatric clinics. The participants were randomly assigned in to two experimental and control groups. The data were gathered using the panic belief questionnaire which was completed in pretest, posttest and follow-up stages by the participants. MCBT was conducted in 8 sessions on the experimental group while the control group, in addition to the reception of common medical treatments, was laid in waiting list for psychological therapy. Results: According to the results of covariance analysis, the mean of panic beliefs scores obtained in the experimental group were significantly lower than those of the control group (p< 0.05). Conclusion: Panic female patients who attended in MCBT acquired lower scores in panic belief than the control group. Therefore, the results demonstrate that MCBT approach causes to keduce panic beliefs in panic female patients.
Haleh Sadat Tavakkol Afshari, Masoud Homayouni Tabrizi, Touran Ardalan,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Among nano-pharmaceutical materials, nanoemulsions are an important tool in the field of nanotechnology. They have been designed for clinical and therapeutic applications. Since the therapeutic efficacy of cancer is measured by the ability of the drug to reduce and eliminate tumors without damaging healthy tissues, nanoemulsions can be useful as a targeted drug carrier. Therefore, we are going to study the antioxidant and anticancer effects of nanoemulsions prepared using dill essential oil.
Methods and Materials Evaluate the antioxidant properties, we used DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid]) tests. We also applied MTT assay for the evaluation of induced cytotoxicity in liver hepatocellular carcinoma cells and normal human umbilical vein endothelial cells.
Ethical Considerations The Research Ethics Committee of Islamic Azad University (Mashhad Branch) approved this study (Code: IR.IAU.MSHD.REC.1398.027).
Results Nanoemulsions prepared using dill essential oil has a good potential for inhibiting DPPH (IC50=500 μg/mL) and ABTS (IC50=420 μg/mL) radicals. Nanoemulsions also caused a little toxicity to both cell lines. Nanoemulsions reduced cell viability in a dose-dependent manner and the cytotoxicity induced to cancer cells was higher than normal cells.
Conclusion The present study indicates that nanoemulsions prepared by dill essential oil will have the potential to become a therapeutic strategy for diseases caused by oxidative stress.
Haleh Sadat Tavakkol Afshari, Masoud Homayouni Tabrizi, Touran Ardalan,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Angiogenesis is the process of forming new blood vessels from the old ones; it plays an important role in physiological conditions, such as growth, wound healing, and reproduction. This process also plays a vital role in pathological phenomena and the occurrence of various diseases, especially tumor growth and metastasis. The present study evaluated the anti-angiogenic effects of nanoemulsion synthesized from Anethum graveolens essential oil using the CAM method.
Methods & Materials: To investigate the anti-angiogenic effects on the second day of incubation, a window was opened on the eggs. Subsequently, on the eighth day, a gelatin sponge with nanoemulsion with different doses (12.5, 25, and 50 μg/mL) was inserted on the chorioallantoic membrane. On the 12th day of incubation, a research stereomicroscope was used to evaluate the rate of angiogenesis and imaging of the treated area. Vascular factors were examined by Image J software.
Ethical Considerations: This study was approved by the Research Ethics Committee of Mashhad Branch, Islamic Azad University (Code: IR.IAU.MSHD.REC.1398.027).
Results: The obtained results concerning the effect of nanoemulsion on the rate of angiogenesis in the CAM test indicated a decrease in the length and number of vessels of the chorioallantoic membrane in the treated samples, compared to the controls. Moreover, there was a reduction in the height and weight of treated fetuses, compared to the untreated fetuses (P<0.05).
Conclusion: The anti-angiogenic activity of nanoemulsion synthesized from Anethum graveolens essential oil indicated the possible use of this substance for diseases, like cancer, in which the formation of blood vessels is inhibited. Therefore, Anethum graveolens nanoemulsion can be suggested as an agent for further cancer studies.
Vahid Hemmati Sabet, Saeedeh Alsadat Hoseini, Karim Afsharinia, Mokhtar Arefi,
Volume 24, Issue 4 (October & November 2021)
Abstract
Background and Aim: The main objective of the current study was to compare the effectiveness of schema therapy and dialectical behavior therapy (DBT) on health-promoting lifestyle (HPL) and quality of life (QoL) of HIV/AIDS patients.
Methods & Materials: The current study was an experimental study based on a pre-test-post-test design with a control group, and based on the objectives, it can be considered an applied study. The statistical population of the study included all HIV patients monitored by behavioral disorders clinics of the Healthcare Organization Centers in Hamedan County in Iran in 2019-2020. Using simple random sampling method, 45 patients were randomly selected from Shohada Clinic in Hamedan as the sample of the study, followed by randomly assigning them to three 15-member groups, i.e., two intervention groups and a control group. In order to measure the research variables, the Health-Promoting Lifestyle Profile (HPLP) (1987) and the Short Form (36) Health Survey (SF-36, 2001) were utilized. The obtained data were analyzed using ANCOVA in SPSS v. 12.
Ethical Considerations: The Ethics Committee of Hamedan University of Medical Sciences approved the study (Code: IR.UMSHA.REC.1398.1063). This study has been registered in the Iranian Registry of Clinical Trials (Code: IRCT20120215009014N348).
Results: The results of ANCOVA indicate that schema therapy and DBT affect HPL and quality of life, and there was a significant difference between the two groups (P<0.001).
Conclusion: The results show that while both therapy methods affect the selected variables, schema therapy is more effective than DBT on HPL and Quality of Life (QoL).
