Volume 24, Issue 5 (December & January 2021)
J Arak Uni Med Sci 2021, 24(5): 640-645 |
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Azadeh S S, Keshmiri Neghab H. The Potential of the Use of the Flavonoid Fisetin in the Treatment of Coronavirus by Inhibition of Angiotensin Converting Enzyme 2. J Arak Uni Med Sci 2021; 24 (5) :640-645
URL: http://jams.arakmu.ac.ir/article-1-6362-en.html
URL: http://jams.arakmu.ac.ir/article-1-6362-en.html
1- Department of Biology, Faculty of Basic Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran. , sara.azadehhh@gmail.com
2- Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute Academic Center for Education, Culture and Research, Tehran, Iran.
2- Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute Academic Center for Education, Culture and Research, Tehran, Iran.
Abstract: (3630 Views)
In December 2019, a new type of coronavirus called COVID-19 was identified as an unknown cause of pneumonia in Wuhan, China. The pandemic virus was transmitted to humans from a type of seafood that could spread significantly among humans in a short time. Clinical signs of coronaviruses include fever, severe sweating, cough, pneumonia, and a weakened immune system, with acute cases leading to death. One of the most important coronavirus receptors in the host cell is the angiotensin 2 converting enzyme. It is noteworthy that the patient’s recovery process increases during the inhibition of angiotensin 2 converter enzyme. Therefore, the administration of drugs that inhibit this enzyme can be effective in recovering a patient with coronavirus. Flavonoids are one the inhibitors of the angiotensin-converting enzyme, which is abundant in fruits and vegetables. Fistula, a type of flavonoid known in nature as an antioxidant and anti-inflammatory agent in the treatment of many, can be effective in the treatment of coronavirus by inhibiting the enzyme converter angiotensin 2.
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