Volume 28, Issue 6 (1-2026)
J Arak Uni Med Sci 2026, 28(6): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ganji A, farahani I, Sakhaie M. Protective Effects of Low-Frequency Electromagnetic Fields on the Cerebral Cortex in a C57BL/6 Female Mouse of Experimental Autoimmune Encephalomyelitis: A Histological and Molecular Study. J Arak Uni Med Sci 2026; 28 (6)
URL: http://jams.arakmu.ac.ir/article-1-8233-en.html
URL: http://jams.arakmu.ac.ir/article-1-8233-en.html
1- Associated Professor, Department of Immunology, School of Medicine, Arak University of Medical Sciences, AND, Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
2- MSc, Department of Immunology, School of Medicine, Arak University of Medical Sciences,Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
3- Assistance Professor, Department of anatomical science, School of Medicine, Arak University of Medical Sciences, Arak, AND Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran ,mh.sakhaie@arakmu.ac.ir
2- MSc, Department of Immunology, School of Medicine, Arak University of Medical Sciences,Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
3- Assistance Professor, Department of anatomical science, School of Medicine, Arak University of Medical Sciences, Arak, AND Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran ,
Abstract: (287 Views)
Introduction: Experimental Autoimmune Encephalomyelitis (EAE) is an immune-mediated inflammatory model of multiple sclerosis that induces axonal loss, demyelination and motor disabilities. Electromagnetic fields (EMFs) possess multiple biological capabilities that affect the nervous system. The aim of the present study is to investigate the beneficial effect of low-intensity electromagnetic field on clinical symptoms, histological structure and gene expression in the cerebral cortex.
Methods: Forty-eight female C57BL/6 mice were used for this study. Following model induction, with MOG immunization the animals exposed to the EMFs (1 mT,50 Hz) over a period of two weeks. At the end of experiments, the body weight, clinical score (paralysis score) and lymphocyte infiltration of the cortex were evaluated in experimental groups. Moreover, the mRNA expression levels Bcl2, BDNF and Nrf2 are also were studied by using quantitative polymerase chain reaction (qPCR).
Results: The EMFs, significantly reduced the clinical symptom scores, decreased lymphocytic infiltration. The applied EMF also upregulated the expression of Bcl2, BDNF and Nrf2 in the cerebral cortex in compared to EAE model.
Conclusions: Overall, the present study demonstrated that electromagnetic fields, as a complementary therapy, exert significant neuroprotective properties in EAE by inhibiting oxidative stress and reducing neural tissue inflammation.
Methods: Forty-eight female C57BL/6 mice were used for this study. Following model induction, with MOG immunization the animals exposed to the EMFs (1 mT,50 Hz) over a period of two weeks. At the end of experiments, the body weight, clinical score (paralysis score) and lymphocyte infiltration of the cortex were evaluated in experimental groups. Moreover, the mRNA expression levels Bcl2, BDNF and Nrf2 are also were studied by using quantitative polymerase chain reaction (qPCR).
Results: The EMFs, significantly reduced the clinical symptom scores, decreased lymphocytic infiltration. The applied EMF also upregulated the expression of Bcl2, BDNF and Nrf2 in the cerebral cortex in compared to EAE model.
Conclusions: Overall, the present study demonstrated that electromagnetic fields, as a complementary therapy, exert significant neuroprotective properties in EAE by inhibiting oxidative stress and reducing neural tissue inflammation.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2026/01/6 | Accepted: 2026/01/18
Received: 2026/01/6 | Accepted: 2026/01/18
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
