Volume 20, Issue 11 (2-2018)
J Arak Uni Med Sci 2018, 20(11): 76-86 |
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Kaviani B, Sazegar H, Zia-jahromi N, Mohamadi Farsani F. Investigation of the Effects of rs137852599 Single-nucleotide Polymorphism Existence in Drug Resistance against Treatment with Enzalutamide in Individuals Diagnosed with Prostate Cancer in Isfahan Province. J Arak Uni Med Sci 2018; 20 (11) :76-86
URL: http://jams.arakmu.ac.ir/article-1-5262-en.html
URL: http://jams.arakmu.ac.ir/article-1-5262-en.html
1- Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran.
2- Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran. ,hoseinsazgar@yahoo.com
3- Department of Biology, Faculty of Basic Sciences, Isfahan University, Isfahan, Iran.
2- Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran. ,
3- Department of Biology, Faculty of Basic Sciences, Isfahan University, Isfahan, Iran.
Abstract: (3563 Views)
Abstract
Background: The aim of this study is to investigate the role of rs137852599 single-nucleotide polymorphism in the androgen receptor coding gene on drug resistance against treatment with Enzalutamide in individuals diagnosed with prostate cancer.
Materials and Methods: In this case-control study, the ARMS-PCR analysis was conducted on androgen receptor coding gene in 50 patients diagnosed with prostate cancer with drug resistance and on 50 patients diagnosed with prostate cancer without drug resistance. The statistical analyses were performed using the GeNePop server and then the results were investigated by the SISA server.
Results: The allele frequencies of A and C alleles in rs137852599 were 0.78 and 0.22 for drug resistant and 0.94 and 0.06 for non-drug resistance groups. The results indicated that there is a meaningful relationship between drug resistance and rs137852599 single-nucleotide polymorphism
(p = 0.020).
Conclusion: The existence of single-nucleotide polymorphisms may result in drug resistance in individuals diagnosed with prostate cancer. Therefore, investigation of the existence of such polymorphisms can be effective in prescription of suitable drugs for these patients.
Background: The aim of this study is to investigate the role of rs137852599 single-nucleotide polymorphism in the androgen receptor coding gene on drug resistance against treatment with Enzalutamide in individuals diagnosed with prostate cancer.
Materials and Methods: In this case-control study, the ARMS-PCR analysis was conducted on androgen receptor coding gene in 50 patients diagnosed with prostate cancer with drug resistance and on 50 patients diagnosed with prostate cancer without drug resistance. The statistical analyses were performed using the GeNePop server and then the results were investigated by the SISA server.
Results: The allele frequencies of A and C alleles in rs137852599 were 0.78 and 0.22 for drug resistant and 0.94 and 0.06 for non-drug resistance groups. The results indicated that there is a meaningful relationship between drug resistance and rs137852599 single-nucleotide polymorphism
(p = 0.020).
Conclusion: The existence of single-nucleotide polymorphisms may result in drug resistance in individuals diagnosed with prostate cancer. Therefore, investigation of the existence of such polymorphisms can be effective in prescription of suitable drugs for these patients.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/08/8 | Accepted: 2017/12/18
Received: 2017/08/8 | Accepted: 2017/12/18
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