Volume 20, Issue 3 (6-2017)                   J Arak Uni Med Sci 2017, 20(3): 31-38 | Back to browse issues page

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Khosrofar M, Pourreza M R, Asgharzadeh S, Tahmasebi P, Ali Asgari E, Ghasemikhah R, et al . Genetic Linkage Analysis of the DFNB21 Locus in Autosomal Recessive Hearing Loss in large families from Khuzestan Province.. J Arak Uni Med Sci 2017; 20 (3) :31-38
URL: http://jams.arakmu.ac.ir/article-1-4835-en.html
Genetic Linkage Analysis of the DFNB21 Locus in Autosomal Recessive Hearing Loss in large families from Khuzestan Province.
Mahtab Khosrofar1 , Mohammad Reza Pourreza2 , Samira Asgharzadeh3 , Parisa Tahmasebi4 , Elahe Ali Asgari1 , Reza Ghasemikhah5 , Nader Saki6 , Javad Mohammadi-asl7 , Morteza Hashemzadeh Chaleshtori8 , Mohammad Amin Tabatabaiefar9
1- Department of Cellular & Molecular Biology, School of Basic Sciences, East Tehran Branch (Ghiamdasht), Islamic Azad University, Tehran, Iran
2- Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3- School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4- Department of Biology, School of Sciences, Ilam University, Ilam, Iran
5- Department of Parasitology and Mycology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
6- Hearing Research Center, Department of Otorinholaringology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7- Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8- Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
9- Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , tabatabaiefar@med.mui.ac.ir
Abstract:   (5592 Views)

Abstract

Background: Hearing loss (HL) is the most common congenital defect in humans. One or two in thousand newborn babies have prelingual hearing loss. Autosomal recessive non-syndromic hearing loss (ARNSHL) is the most common form of hereditary deafness. Hearing loss is more common in the developing countries which is due to genetic and environmental (cultural -health factors) reasons. HL has a wide range of clinical demonstrations including: congenital or late onset, conductive or sensory-neural, syndromic or non-syndromic hearing loss. The goal of this project is to determine the portion of the DFNB21 (TECTA) in ARNSHL in families with negative GJB2 gene in Khuzestan province.

Materials and Methods: We studied 21 families with ARNSHL with at least 4 patients and negative for GJB2 mutations from Khuzestan province. Genetic linkage analysis was performed using STR markers linked to DFNB21 locus.

Results: Following genetic linkage analysis and haplotyping, out of 21 families with ARNSHL, one family showed linkage to the DFNB21 (TECTA) locus.

Conclusion: The results of this project confirm other studies in Iran and give insight into the most common loci causing ARNSHL in Iran which could be helpful in research and clinic.

Keywords: Autosomal recessive non-syndromic hearing loss, DFNB21 locus, Genetic linkage.
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/12/19 | Accepted: 2017/04/30
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