Background: Interleukin-1&beta (IL-1&beta) as a cytokine act in relationship to development of obesity and Insulin resistance. purpose of the study was compare the effects of Ramadan fasting (as dietary pattern) and aerobic exercise training on IL-1&beta and Insulin resistance in non-active obese subjects.
Materials and Methods: This study was semi-experimental research with repeated measures design. In this study, 18 obese male in Mashhad (between 40 to 50 years old and body mass index>30 Kg/m2) randomly was selected and after it was divided into fasting (N=9) and fasting and aerobic exercise training (N=9) groups. While the first group performed the fasting, then other group was performed aerobic exercise training for 27 sessions. They also performed the fasting. Finally, blood samples were taken for four different times.
Results: Statistic analysis shown that body fat percent of subjects was significantly decreased in both groups (p<0.05). Also, amount of insulin resistance was significantly decreased in fasting group (p<0.05). In addition, amount of IL-1&beta was significantly decreased in both groups(p<0.05).
Conclusion: Research results shown that levels of IL-1&beta decreased by fasting and especially by aerobic exercise training and it may lead to the decrease of insulin resistance in obese subjects.