Volume 15, Issue 4 (September 2012)
J Arak Uni Med Sci 2012, 15(4): 34-39 |
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Shojapuor M, Mosayebi G, Ghasami K, Ghazavi A, Sadeghi A. Vitamin D receptor gene polymorphism in patients with multiple sclerosis in Mar kazi Province. J Arak Uni Med Sci 2012; 15 (4) :34-39
URL: http://jams.arakmu.ac.ir/article-1-1287-en.html
URL: http://jams.arakmu.ac.ir/article-1-1287-en.html
1- Arak University of Medical Sciences
2- Arak University of Medical Sciences ,sadegha@arakmu.ac.ir
2- Arak University of Medical Sciences ,
Abstract: (14127 Views)
Background: Multiple sclerosis (MS) is an autoimmune disease which demyelinates the central nervous system. Vitamin D, is a potential environmental factor which influences this disease. The majority of the biological activities of the polymorphism forms of vitamin D are done through its receptor gene (VDRG). The aim of this study was to examine the relationship between BsmI polymorphisms in VDRG and the incidence of MS. Materials and Methods: In this case-control study, the BsmI polymorphism in the VDRG was studied in 80 Iranian MS patients and 50 healthy controls of the same genetic background and age through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method Results: There was a significant difference in the frequency of BsmI VDRG polymorphism genotypes between MS patients and controls (P=0.023). Conclusion: This study indicated that the VDRG BsmI polymorphism is associated with MS in this population.
Subject:
Basic Sciences
Received: 2011/08/23
Received: 2011/08/23
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