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:: Volume 10, Number 3 (6-2007) ::
amuj 2007, 10(3): 48-57 Back to browse issues page
Effect of Allium Sativum extract on acid and pepsin secretion in basal condition and stimulated with Pentagastrin in rat
Mehrdad Shahrani , Fatemeh Nabavizade, Mahmoud Rafian, Hedayat Shirzad, Morteza Hashemzade, Hossein Yousefi, Reza Khadivi, Asadolah Amini, Bahman Khalili, Ghorbanali Rahimian
MS , mehrdadeshahrani2000@yahoo.com
Abstract:   (13007 Views)
Introduction: Allium Sativum (garlic) is used widely in the world, especially in Iran. This plant is used in cooking foods as an odorant. In Iran it is believed that it is useful for gastrointestinal disorders. So in this study the effect of Allium Sativum extract on acid and pepsin secretion in rat is investigated. Materials and Methods: This experimental study is performed on two groups of rats (12 in each group: control group and allium sativum group). After anesthesia with nesdonal (50 mg/kg, ip), rats had gone under surgical tracheotomy, laparatomy and gasterodeodenostomy. In garlic group Allium Sativum extract (100mg/kg) was introduced into the stomach by gasterodeodenostomy canula. In order to stimulation of acid and pepsin secretion, Pentagastrin was used (25mcg/kg, ip). Stomach secretion was washed out and acid was measured using titerimetery and pepsin using Anson method. Data was analyzed using t-test. Results: Allium Sativum caused a meaningful increase in acid and pepsin secretion in garlic group comparing to control group (p<0.001). Pentagastrin also increased acid and pepsin secretion in control group (p<0.001). Conclusion: Using garlic in nutritional regimen causes an increase in acid and pepsin secretion in those using this plant.
Keywords: Allium Sativum, extract, gastric acid, pepsin, Pentagastrin
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Subject: General
Received: 2008/10/15
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Shahrani M, Nabavizade F, Rafian M, Shirzad H, Hashemzade M, Yousefi H, et al . Effect of Allium Sativum extract on acid and pepsin secretion in basal condition and stimulated with Pentagastrin in rat. amuj. 2007; 10 (3) :48-57
URL: http://amuj.arakmu.ac.ir/article-1-68-en.html
Volume 10, Number 3 (6-2007) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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