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:: Volume 20, Issue 6 (9-2017) ::
AMUJ 2017, 20(6): 74-82 Back to browse issues page
In-Vitro Efficacy of Plantago lanceolata L. Extracts on Trichomonas Vaginalis
Mohammad Matini , Samira Bakhtiarnejad , Dara Dastan , Amir Hossein Maghsood , Mohammad Fallah
Assistant Professor, PhD in Parasitology, Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , matini@umsha.ac.ir
Abstract:   (1003 Views)
Background: Trichomoniasis is one of the most common non viral sexually transmitted diseases worldwide. The aim of this study was to investigate the effect of Plantago lanceolata extracts on Trichomonas vaginalis.
Materials and Methods: In this study, after collection and drying of P. lanceolata, n-hexanic, ethyl acetate, methanol and hydroalcoholic extracts, they were prepared by maceration. Five clinical T. vaginalis isoleates subjected to extract suscebtibility testing, in comparison of metronidazole. Minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) tests were carried out in duplicate and repeated two times for each T. vaginalis isolate.
Results: The results showed that the extracts of P. lanceolata had potent antitrichomonal activity. The most antitrichomonal activity was related to ethyl acetate extract with the least MIC of 500 µg/ml and mean of 1525 µg/ml, after 48 hrs incubation. And also, the lowest antitrichomonal activity was related to hydroalcoholic and methanolic extract with the least and mean MIC of 2000 µg/ml. The results of MLC and MIC tests were identical and this finding confirmed the trichomonacidal activity of the extracts. The drug suscebtibility testing showed that the T. vaginalis isoleates were susceptibale to metronidazole ranging from 3.1 to 6.2 µg/ml with a mean and standard deviation of 4.2 ± 1.5 µg/ml.
Conclusion: This study showed that the extracts of P. lanceolata hav e a considerable activity on T. vaginalis parasite. Hence, further studies are needed to clear more details of antimicrobial properties of  P. lanceolata compounds.
Keywords: Extract, Metronidazole, Plantago lanceolata, Trichomonas vaginalis
Full-Text [PDF 773 kb]   (240 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2017/05/7 | Accepted: 2017/08/2 | Published: 2017/08/21
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Matini M, Bakhtiarnejad S, Dastan D, Maghsood A H, Fallah M. In-Vitro Efficacy of Plantago lanceolata L. Extracts on Trichomonas Vaginalis. AMUJ. 2017; 20 (6) :74-82
URL: http://amuj.arakmu.ac.ir/article-1-5089-en.html

Volume 20, Issue 6 (9-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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