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:: Volume 20, Number 2 (5-2017) ::
amuj 2017, 20(2): 22-32 Back to browse issues page
Comparison of Thromboemboli Prophylactic Effect of Aspirin and Low Dose Warfarin in Standard Risk Multiple Myeloma Patients that Treated with Regimens Containing Thalidomide
Seyed Amir Dadkhahi, Ali Arash Anoushirvani , Reza Aghabozorgi
Assistant Professor, Hematology and Cancer Speciatist, Ayatollah Khansari Education and Treatment Center, School of Medicine, Arak University of medical Sciences, Arak, Iran , anoush_aa@yahoo.com
Abstract:   (766 Views)

Background: Most of the current regimens in the treatment of multiple myeloma include thalidomide. Thalidomide is a modulator of the immune system and according to several studies, its main complication is thromboembolism. The aim of this study is to compare the thromboemboli prophylactic effect of aspirin and low dose warfarin in standard risk multiple myeloma patients that treated with regimens containing thalidomide.

Materials and Methods: In this double- blind clinical trial study, sixty-six patients with multiple myeloma under treatment with thalidomide-containing regimens with standard risk for thromboembolism who were admitted to Khansari hospital, entered the study according to inclusion and exclusion criteria. The incidence of thromboembolism in these patients was evaluated.

Results: Five patients in the warfarin group and 2 patients in the aspirin group had thromboemboli. Chi square analyses showed no significant difference between groups (p=0.635).

Conclusion: The results showed that both drugs are effective in preventing thromboembolism and can be used as a prophylactic treatment.

Keywords: Aspirin, Multiple myeloma, Thromboemboli, Warfarin
Full-Text [PDF 829 kb]   (194 Downloads)    
Type of Study: Original Atricle | Subject: Oncology
Received: 2017/02/21 | Accepted: 2017/03/7 | Published: 2017/04/19
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Dadkhahi S A, Anoushirvani A A, Aghabozorgi R. Comparison of Thromboemboli Prophylactic Effect of Aspirin and Low Dose Warfarin in Standard Risk Multiple Myeloma Patients that Treated with Regimens Containing Thalidomide . amuj. 2017; 20 (2) :22-32
URL: http://amuj.arakmu.ac.ir/article-1-4957-en.html
Volume 20, Number 2 (5-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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