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:: Volume 20, Issue 1 (4-2017) ::
AMUJ 2017, 20(1): 14-23 Back to browse issues page
Metabolic Response to Soy Supplementation in Women with Polycystic Ovary Syndrome
Mehri Jamilian , Reyhaneh Sahebkashaf
Associate Professor, Department of Gynecology, Arak University of Medical Sciences, Arak, Iran , mjamilan@yahoo.com
Abstract:   (929 Views)


Background: We are aware of no study examining the effects of Soy supplementation on patients with polycystic ovary syndrome (PCOS).This study was conducted to evaluate the effects of Soy supplementation on metabolic profiles in women with PCOS.

Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted among 70 women diagnosed with PCOS. Participants were randomly divided into two groups to receive 50 mg Soy isoflavone supplements (n=35) or placebo (n=35) for 12 weeks. Fasting blood samples were taken at baseline and after a 12-week intervention to quantify related factors.

Results: Intervention group, subjects who received Soy supplements had significantly decreased total serum testosterone levels (-0.2±0.4 vs. +0.1±0.3 ng/mL, p=0.01) compared with the placebo. In addition, a significant rise in plasma glutathione (+96.0±102.2 vs. +22.7±157.8 µmol/L, p=0.04) and a significant decrease in malondialdhyde levels (-0.7±0.8 vs. +0.8±2.3, p=0.001) was observed following the consumption of Soy supplements compared with the placebo.

Conclusion: According to this study, Soy supplementation among PCOS women had beneficial effects on metabolic profiles.

Keywords: Metabolic profiles, polycystic ovary syndrome, Soy
Full-Text [PDF 681 kb]   (339 Downloads)    
Type of Study: Original Atricle | Subject: Obstetrics & Gynocology
Received: 2016/12/31 | Accepted: 2017/02/26 | Published: 2017/03/13
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Jamilian M, Sahebkashaf R. Metabolic Response to Soy Supplementation in Women with Polycystic Ovary Syndrome. AMUJ. 2017; 20 (1) :14-23
URL: http://amuj.arakmu.ac.ir/article-1-4863-en.html

Volume 20, Issue 1 (4-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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