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:: Volume 20, Issue 1 (4-2017) ::
AMUJ 2017, 20(1): 24-34 Back to browse issues page
The effect of three-week intensive interval training on Lipocalin-2 and Interleukin1-β in healthy and adult rat Hippocampus
Bahman Hasanvand , Rahman Soori , Sadegh Abbasian , Mahsa Rastegar Moghaddam Mansoori
Lecturer, Department of Physical Education, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran , hasanvand121@gmail.com
Abstract:   (1566 Views)

Abstract

Background: In response to the exercise, variety of inflammatory and anti-inflammatory changes in cytokines were occurred into the tissue spaces and also to the systemic circulation. The purpose of the current study was to determine the effect of three-week intensive interval training on Lipocalin-2 and Interleukin1-β in healthy and adult rat hippocampus.

Materials and Methods: Twenty Wistar rats were divided into training and control groups. Training group performed 15 (bouts) × 4 (min) exercise training for 60 min with 85 to 90% of VO2max used for four sessions/week (for 3 weeks). Then, blood (for ELISA analyzing) and tissue sampling was performed from rat’s hippocampus and they were evaluated by using a Real-Time PCR method. Also, independent and paired t tests were used to define within and between group differences.

Results: Findings showed that gene translations of Lipocalin-2 and Interleukin1-β were significantly decreased in rat’s hippocampus (p=0.0001 and p=0.0001, respectively). Also, similar decreases were shown in serum levels of Lipocalin-2 and Interleukin1-β in rats (p=0.017 and p=0.003, respectively).

Conclusion: It seems that significant decrease of Lipocalin-2 subsequent of short-time intensive interval training is due to decreasing and significant changes in Interleukin1-β. Also, current training protocol on treadmill can significantly decrease levels of Lipocalin-2 and Interleukin1-β in rat serum and hippocampus.

Keywords: Intensive interval training, Interleukin1-β, Lipocalin-2
Full-Text [PDF 739 kb]   (532 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2016/12/4 | Accepted: 2017/02/15 | Published: 2017/03/14
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Hasanvand B, Soori R, Abbasian S, Rastegar Moghaddam Mansoori M. The effect of three-week intensive interval training on Lipocalin-2 and Interleukin1-β in healthy and adult rat Hippocampus. AMUJ. 2017; 20 (1) :24-34
URL: http://amuj.arakmu.ac.ir/article-1-4806-en.html


Volume 20, Issue 1 (4-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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