Volume 20, Issue 1 (4-2017)                   J Arak Uni Med Sci 2017, 20(1): 44-58 | Back to browse issues page

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Heidarianpour A, Razavi Z, Seif M. Effects of Aerobic Exercise and GNRH Agonists on Apelin Serum Levels and Insulin Resistance Index in Girls with Central Precocious Puberty . J Arak Uni Med Sci. 2017; 20 (1) :44-58
URL: http://amuj.arakmu.ac.ir/article-1-4775-en.html
Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Bu-Ali University of Hamedan, Hamedan, Iran , heidarian317@gmail.com
Abstract:   (2135 Views)


Background: The aim of this study was to investigate the effect of aerobic exercise and GnRH agonist on the levels of apelin and insulin resistance index in girls with central precocious puberty.

Materials and Methods: In this study, twenty-five girls (7.44±0.34 years) with precocious puberty were included. They were randomly divided into three groups (drug, n=10, exercise+drug, n=8, and exercise, n=7) and one control group (healthy, n=10). In the experimental group, aerobic exercise for 12 weeks, 3 days/week was done, duration intensity of exercise gradually increased 5 minutes and 5% respectively every 2 week. Also, the GnRH agonists were used as medicine. BMI, the apelin and insulin resistance index were assessed before and after exercise.

Results: Insulin resistance index and apelin serum levels in experimental group (exercise and exercise+ drug) were significantly decreased(p=0.05), while these factors were unchanged in control group (p=0.05). Additionally, BMI in exercie groups was significantly decreased (p=0.000), while it was increased in experimental group (drug group) (p=0.06).

Conclusion: Considering to current data, it could demonstrate that aerobic training and GNRH agonists at the same time can lead to a decrease in BMI and apelin and an improvement in insulin resistance index.

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Type of Study: Original Atricle | Subject: General
Received: 2016/11/19 | Accepted: 2016/12/25 | Published: 2017/03/13

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