Volume 20, Issue 2 (5-2017)                   J Arak Uni Med Sci 2017, 20(2): 78-88 | Back to browse issues page

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Motahari Rad M, Attarzadeh Hosseini S R. Response of Vascular Endothelial Growth Factor and Endostatin to a Session Activity before and after a Period of L-Arginine Supplementation in Active Men. J Arak Uni Med Sci. 2017; 20 (2) :78-88
URL: http://amuj.arakmu.ac.ir/article-1-4733-en.html
Professor, PhD of Sport Physiology, Department of Sport Physiology, Ferdowsi University of Mashhad, Mashhad, Iran , attarzadeh@um.ac.ir
Abstract:   (2433 Views)

Background: The aim of this study was to investigate the response of the most important angiogenic and angiostatic factors to a session activity before and after a period of L-Arginine supplementation in active men.

Materials and Methods: In this practical and semi experimental study, 22 active men were selected by convenience sampling method and they were randomly assigned into supplement (n=11) and placebo (n=11) groups. Baseline levels of VEGF and endostatin were measured, then subjects participated an exhaustive treadmill protocol in pre-test and post-test. Immediately and two hours after the protocol, 3 cc blood samples were prepared. The subjects used daily 0.1 g.kg-1 respectively taking l-arginine and placebo for 14 days. The results were analyzed at the significant level (p<0.05).

Results: Immediately after exercise, the levels of VEGF and VEGF to endostatin ratio were significantly decreased in both groups compared to baseline (p≤0.05), and two hours later this change were lower than the baseline value (p≤0.05). The levels of endostatin immediately after exercise were significantly increased in both groups compared to baseline (p≤0.05) and two hours later this change were lower than the baseline value (p≤0.05). Before and after L-Arginine supplementation, the levels, of VEGF and VEGF to endostatin ratio immediately after exercise were not significant(p≥0.05). while this change in the supplementation group were significantly increased two hours after exercise (p≤0.05). There was no significant change in the levels of endostatin between two groups immediately after exercise (p≥0.05); however, these changes were significantly decreased two hours after exercise (p≤0.05).

Conclusion: It seems that short-term L-arginine supplementation probably stimulate angiogenesis factors in response to exercise in active men.

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Type of Study: Original Atricle | Subject: General
Received: 2016/10/23 | Accepted: 2017/02/26 | Published: 2017/04/19

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