[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 19, Issue 10 (1-2017) ::
amuj 2017, 19(10): 17-24 Back to browse issues page
The Effect of Air Pollution on γ-Glutamyltransferase Enzyme Activity
Nushin Rezaee Vandchali , Mojtaba Fathi , Ali Koolivand , Sheida Malekafzali , Farideh Jalali Mashayekhi
Assistant Professor, PhD of Clinical Biochemistry, Department of Clinical Biochemistry, Arak University of Medical Sciences, Arak, Iran , mashayekhi@arakmu.ac.ir
Abstract:   (1506 Views)


Background: Human exposure to air pollution is associated with an increased risk of diseases such as heart failure, asthma and cancer. It has been suggested that oxidative stress is involved in air pollution-induced disorders. Recently, γ-glutamyltransferase (GGT) is known as a marker of oxidative stress. This study was aimed to evaluate the effect of exposure to outdoor air pollution on enzyme activity of GGT and also usage of GGT serum level as a marker for studying of harmful effects of air pollution in the resident with high air pollution level.

Materials and Methods: In this analytical cross-sectional study, 110 healthy adult men, never-smoking, who worked in an area with high air pollution and 90 men who worked in an area with low air pollution, as control group, were enrolled. All subjects were in the age range of 25-45 years with minimum work history of three years. The GGT activity in the serum samples was determined using a spectrophotometric method.

Results: Our results showed that the serum levels of GGT in the subjects in the areas with high air pollution (33.92 ± 1.61 U/L) did not differ significantly with those of control region (33.62 ± 1.74 U/L).

Conclusion: Overall, this study did not support the hypothesis that GGT enzyme could be considered as an oxidative stress marker following exposure to outdoor air pollution. Further studies with a larger sample sizes and also trials in other areas are required to confirm these results.

Keywords: Air pollution, γ-glutamyltransferase, Oxidative stress
Full-Text [PDF 689 kb]   (397 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/09/10 | Accepted: 2016/10/26 | Published: 2017/01/9
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rezaee Vandchali N, Fathi M, Koolivand A, Malekafzali S, Jalali Mashayekhi F. The Effect of Air Pollution on γ-Glutamyltransferase Enzyme Activity. amuj. 2017; 19 (10) :17-24
URL: http://amuj.arakmu.ac.ir/article-1-4654-en.html
Volume 19, Issue 10 (1-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
Persian site map - English site map - Created in 0.06 seconds with 798 queries by yektaweb 3571