Volume 19, Issue 10 (1-2017)                   J Arak Uni Med Sci 2017, 19(10): 9-16 | Back to browse issues page

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Heidarpanah S, Kohan L, Hashemi S S. Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome. J Arak Uni Med Sci. 2017; 19 (10) :9-16
URL: http://amuj.arakmu.ac.ir/article-1-4579-en.html
Assistant Professor, PhD in Cell and Molecular Biology, Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com
Abstract:   (2066 Views)

Abstract

Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of Fas in ovarian apoptosis. The present study is the first investigation to examine the possible association of Fas rs1800682gene polymorphism with PCOS risk in Iranian women.

Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The Fas rs1800682 gene polymorphism genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk.

Results: There was a significant association between A allele and susceptibility to PCOS(OR =1.4, %95CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index(OR=1.6, %95CI=1.02-2.51, p=0.041).

Conclusion: For the first time, this study showed that Fas rs1800682 polymorphism is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/08/5 | Accepted: 2016/09/3 | Published: 2017/01/9

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