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AMUJ 2017, 20(1): 69-83 Back to browse issues page
Effect of Supplementing Mouse Maternal Diet during Pregnant and Weaning Period by Fish Oil and Vitamin E on Male Offspring Reproductive Organs
Fahimeh Zare Ebrahim Abad , Abdolhosein Shahverdi , Mitra Heidari Nasr Abadi , Alireza Alizadeh
Associate Professor, Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , shahverdi@royaninstitute.org
Abstract:   (1980 Views)


Background: The aim of this study was to investigate the effect of fed fish oil (FO) with or without vitamin E for mothers on the testis cells of male offsprings.

Materials and Methods: Sixty mature female NMRI mice were divided into different groups: control (CTR; Standard diet(vitamin E 50 mg IU/kg) pre and postnatal period); I) Gavages 0.01 ml/day/mother fish oil (FO)+CTR diet during prenatal period; II) Gavages FO+CTR diet during postnatal period; III) consumed VITE(125 mg IU/kg) 2.5 folded greater than standard recommendations(2×)during prenatal period; IV)consumed VITE(2×)diet during pre and postnatal period; V)consumed VITE(2×)diet during postnatal period; VI) Gavages FO+VITE(2×) diet during prenatal period; VII) Gavage FO+VITE(2×)diet during postnatal period ;VIII) Gavages FO+VITE (2×)diet during pre and postnatal period. After weaning, the testes were collected and histological data were analyzed using SAS software by Duncan test.

Results: testes cells length, width and weight was lower in offspring which their mothers fed FO+CTR diet during prenatal, (p<0.05).Vitamin E consumption during postnatal period improved these parameters (p<0.05). Spermatogoni (47 vs. 43), spermatocyte (43 vs. 34), Spermatid (63 vs. 44), Sertoli (0.9 vs. 2), and Leydig (3 vs. 1.7) were increased as FO+VITE was used than CTR (p<0.05).

Conclusion: The positive effects of supplementation maternal diet by FO with VITE or sole VITE was observed. Thus, antioxidants should be consumed along with omega-3 fatty acids in maternal diet.

Keywords: Fish oil, Maternal nutrition, Offspring testes, Vitamin E
Full-Text [PDF 1128 kb]   (598 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/07/14 | Accepted: 2017/01/18 | Published: 2017/03/14
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Zare Ebrahim Abad F, Shahverdi A, Heidari Nasr Abadi M, Alizadeh A. Effect of Supplementing Mouse Maternal Diet during Pregnant and Weaning Period by Fish Oil and Vitamin E on Male Offspring Reproductive Organs. AMUJ. 2017; 20 (1) :69-83
URL: http://amuj.arakmu.ac.ir/article-1-4533-en.html

Volume 20, Issue 1 (4-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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