Volume 19, Issue 10 (1-2017)                   J Arak Uni Med Sci 2017, 19(10): 81-87 | Back to browse issues page

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Mirnezami M. Evaluating the Role of Omega 3 on the Side Effects of Isotretinoin in Patients with the Acnea Vulgaris . J Arak Uni Med Sci. 2017; 19 (10) :81-87
URL: http://amuj.arakmu.ac.ir/article-1-4503-en.html
Assistant Professor, Department of Dermatology, Arak University of Medical Sciences, Arak, Iran , mirnezamim@yahoo.com
Abstract:   (1508 Views)

BACKGROUND: Acne vulgaris is chronic  inflamatory disease  of the pilosebaceous unit.Patients  experience  psychological  burdens like depression ,anxiety , and low self-esteem. Isotretinoin  is used in the treatment of  severe ,recalcitrant acne ;however,treatment  commonly results in associated   with  a  number  of  adverse effects that treatment stopped  consequent  this side effects. The aim of this study is to evaluate  the effect of oral  omega 3 on  side-effects of  isotretinoin .

METHODS:One  hundred eighteen  patients with sever acne vulgaris  were  randomized to two groups. Control group recived  isotretinoin (0.5 mg∕kg) alone and case  group received  isotretinoin (0.5 mg∕kg)  combined  with omega 3 (2 capsuls) daily.the treatment duration was 16 weeks.Mucocutaneous  side-effects  were assessed(4,8,12,16th wk).

RESULTS:Lip  dryness (4,8,12th wk)  and  dryness of nose, skin ,eye  in the 4 th week in the patients treated with isotretinoin and omega3 was lesser than in the patients treated with isotretinoin  (P value < 0.001).

CONCLUSION:Omega 3 decreased  the  mucocutaneous side effects in the patients  with acne   vulgaris   who received  isotretinoin.

Full-Text [PDF 567 kb]   (422 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2016/06/24 | Accepted: 2017/01/9 | Published: 2017/01/9

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