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:: Volume 13, Number 1 (4-2010) ::
amuj 2010, 13(1): 97-104 Back to browse issues page
The protective effects of Melissa officinalis leaves usage on learning disorder induced by lead acetate administration during pre and postnatal periods in rats
Morteza Behnam Rassouli , Nargess Ghayour, Majid Afsharian, Maryam Tehranipour, Mohammad Bagher Ghayour
Prof. , behnam@um.ac.ir
Abstract:   (16236 Views)
Background: Oxidative stress is one of the probable molecular mechanisms involved in lead (Pb) neurotoxicity. On the other hand, lemon balm (Melissa officinalis) which is widely used in traditional medicine, has a high antioxidant activity. In this study, the protective impacts of Melissa officinalis on the adverse effects of Pb toxicity on learning ability were investigated. Materials and Methods: In this experimental-clinical trial, 40 virgin Wistar rats were mated and divided into control, control positive (vitamin C+Pb), control negative (Pb), and 3 Pb and Mellisa experimental groups. Mellisa was orally administered in three doses including + 25, 50 and 100 mg/ kg of body weight daily. Treatment started from 7th day of gestation and continued through pregnancy and lactation periods. The three month- old offsprings in each group were assessed in terms of memory and learning ability by Morris water maze test and the results were compared between the groups. Results: Exposure to Pb during and after gestation leads to learning disorders. While concomitant administration of Pb and Melissa, as well as vitamin C can, to a large degree, reduce the adverse effects of Pb on learning abilities. Conclusion: Since no significant differences were obtained from the comparison of results in the control, Pb+M and vitamin C+Pb groups, it can be concluded that Melissa has antioxidant impacts equal to vitamin C. Therefore, similar to vitamin C, Mellisa can decrease the neurotoxic effects of Pb.
Keywords: Antioxidants, Lead acetate, Learning, Melissa
Full-Text [PDF 319 kb]   (2257 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/09/1
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Behnam Rassouli M, Ghayour N, Afsharian M, Tehranipour M, Ghayour M B. The protective effects of Melissa officinalis leaves usage on learning disorder induced by lead acetate administration during pre and postnatal periods in rats. amuj. 2010; 13 (1) :97-104
URL: http://amuj.arakmu.ac.ir/article-1-440-en.html
Volume 13, Number 1 (4-2010) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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