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:: Volume 13, Number 2 (6-2010) ::
amuj 2010, 13(2): 125-133 Back to browse issues page
The investigation of the long-term effects of aquatic extraction of Cannabis sativa on spatial memory consolidation in Rats
Morteza Kafaee Razavi , Saeedeh Ebrahimpour, Maryam Tehranipour, Morteza Behnam Rasouli
M.S stdent , mortezakafaee@mshdiau.ac.ir
Abstract:   (11911 Views)
Background: From a physiologic point of view, memory is formed through changes in synaptic conductivity from one neuron to the next. These changes result in the formation of long-term potentiation for conducting a message. Cannabis sativa has more than 61 components that are called cannabinoid. The aim of this study was to investigate the effect of aquatic extraction of cannabis sativa seed on spatial memory consolidation in rats. Materials and Methods: First, 40 Wistar rats, each nearly 250-320g, were divided into four experimental groups and a control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To consolidate spatial memory, Morris water maze (MWM) test was administered in seven sessions, four trials for each session. Experimental groups 1, 2, 3 and 4 received 50mg/kg-1, 100mg/kg-1, 150mg/kg-1, 210mg/kg-1 peritoneal injections (IP), respectively. After memory consolidation, the position of platform area was changed and MWM was repeated for five days. Results: The results show that experimental groups 1, 2, and 3 had a significant decrease in learning time in the comparison to the control group (p<0.05), whereas experimental group 4 with a 210mg/kg-1 dose did not reveal any significant difference in comparison to the control group (p<0.05). Conclusion: It is likely that this long-term potentiation is done through depolarization-induced suppression inhibition (DSI) and depolarization-induced suppression excitatory (DSE) mechanisms in the CA1 area of Hippocamp that lead to neuro-plasticity through neurotransmitter regulation.
Keywords: Cannabis sativa, LTP, Spatial memory, Water moris maze
Full-Text [PDF 475 kb]   (1623 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/07/31
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Kafaee Razavi M, Ebrahimpour S, Tehranipour M, Behnam Rasouli M. The investigation of the long-term effects of aquatic extraction of Cannabis sativa on spatial memory consolidation in Rats. amuj. 2010; 13 (2) :125-133
URL: http://amuj.arakmu.ac.ir/article-1-406-en.html
Volume 13, Number 2 (6-2010) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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