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:: Volume 18, Number 12 (3-2016) ::
amuj 2016, 18(12): 24-32 Back to browse issues page
Comparing the Expression Levels of Toll Like Receptors 2, 4 and, in Normal and Cancerous Tissues of Patients with Laryngeal Carcinoma
Bijan Khademi, Mahboubeh Razmkhah, Ebrahim Eftekhar, Ahmad Hosseini, Hossein Hamedi
Resident, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (1991 Views)
Background: Laryngeal carcinoma induce immune system suppression in tumour micro environments with unknown mechanism. Toll like receptors (TLRs) are important molecules which play a critical role in the management and induction of immune responses. In this regard, the importance and the role of TLR 2, 4 and 9 have not been studied together in laryngeal cancer. The present study aims to evaluate the expression level of TLR2, TLR4 and TLR9 in patients with laryngeal carcinoma.

Materials and Methods: 89 tumour samples and 35 tumour-free tissues were obtained from laryngeal carcinoma male patients and the expression level of TLR2, TLR4 and TLR9 was analysed using Real-time PCR method.

Results: The expression level of TLR2 was increased as the result of increasing lymph node involvement, pretumoral involvement and regional metastasis. Also, the TLR4 gene expression levels were increased 1.5 fold in patients with lymph node involvement. The expression Level of TLR9 was increased by increasing stage and primary tumour involvement. The expression pattern of TLR2 and TLR4 in tumour and tumour-free tissues was the same, while TLR9 gene expressions show higher level in tumour tissues than its normal tissue. None of our findings were statistical significant.

Conclusion: we have shown that the expression status of TLR2, TLR4 and TLR9 in patients with laryngeal cancer was correlated with their clinicopathologic features. Additionally, the expression level of TLRs in cancerous and non-cancerous tissues shows no significant changes.

Keywords: Laryngeal cancer, Toll like receptor 2, TLR4, TLR9
Full-Text [PDF 650 kb]   (381 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2015/08/31 | Accepted: 2015/10/31 | Published: 2016/02/17
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Khademi B, Razmkhah M, Eftekhar E, Hosseini A, Hamedi H. Comparing the Expression Levels of Toll Like Receptors 2, 4 and, in Normal and Cancerous Tissues of Patients with Laryngeal Carcinoma. amuj. 2016; 18 (12) :24-32
URL: http://amuj.arakmu.ac.ir/article-1-3940-en.html
Volume 18, Number 12 (3-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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