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:: Volume 19, Number 1 (4-2016) ::
amuj 2016, 19(1): 23-31 Back to browse issues page
Association of rs1042658 Polymorphism of the CSF3 Gene with the Susceptibility of Recurrent Pregnancy Loss in Women of Fars Province
Kobra Jahangirizade, Mahboobeh Nasiri , Naeimehossadat Asmarian
Assistant Professor Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran. , nasiri@iaua.ac.ir
Abstract:   (1987 Views)

Background: Recurrent pregnancy loss (RPL) is a heterogeneous condition with the prevalence of more than 1% among women of reproductive age, which is defined as the occurrence of more than two miscarriages. Immune-mediators, cytokines, determine the role of immune cells in response to tissue incompatibility conditions. Colony stimulating factor 3 (CSF3) is a cytokine affecting the expression of other cytokines such as IL-4, and suppressing the immune response against semi-allograft embryo. This study was done for the first time on the association of the rs1042658 polymorphism at 3’UTR of the CSF3 gene with the susceptibility to recurrent pregnancy loss, supposing the effect of it on the expression level and stability of the CSF3 gene transcript.

Materials and Methods: 122 RPL women and 140 healthy fertile women as a control group were enrolled in this case-control study. Genotype distribution of the selected polymorphism was evaluated by T-ARMS PCR method and the results were analyzed by logistic regression test.

Results: comparison of the genotypic frequencies in the 3'UTR of the CSF3 gene in patients and controls resulted in the statistically significant difference in the incidence of pregnancy loss in order to the protection effect of the genotypes carrying T allele was observed between two groups (p<0.05). History of the abortion among the relatives of RPL women versus the relatives of controls showed significant differences (p=0.05).

Conclusion: Findings showed significant relationship between rs1042658 polymorphism and the risk of recurrent pregnancy loss, which can affect the susceptibility of the condition.

Keywords: CSF3, Cytokine, Polymorphism, Recurrent pregnancy loss
Full-Text [PDF 628 kb]   (594 Downloads)    
Type of Study: Original Atricle | Subject: Obstetrics & Gynocology
Received: 2015/08/7 | Accepted: 2015/11/29 | Published: 2016/03/14
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Jahangirizade K, Nasiri M, Asmarian N. Association of rs1042658 Polymorphism of the CSF3 Gene with the Susceptibility of Recurrent Pregnancy Loss in Women of Fars Province. amuj. 2016; 19 (1) :23-31
URL: http://amuj.arakmu.ac.ir/article-1-3899-en.html
Volume 19, Number 1 (4-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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