Volume 12, Issue 2 (9-2009)                   AMUJ 2009, 12(2): 73-87 | Back to browse issues page

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Shariat zadeh M A, Hamta A, Solimani M, Rasoli Z. Determination of chromosomal changes in DMBA-induced skin cancer in SD rat strains. AMUJ. 2009; 12 (2) :73-87
URL: http://amuj.arakmu.ac.ir/article-1-386-en.html
Associat professor
Abstract:   (11742 Views)
Background: Skin cancer is one of the most important cancers in the world. This cancer is more common in men than women. We survey chromosomal changes in DMBA-induced skin cancer in SD rat strains. Methods and Materials: In this fundamental study, 20 SD rat strains were randomly divided into case and contal group. DMBA (2.5 mg) was injected to SD rat strains subcutaneously therefore skin cancer model for studies was created. Tumors became subjects for cell culture and metaphase chromosomal were prepared. Finally G-banding were stained. We have also transmitted genomic information from rat to human using suitable databases and Gene were determined. Results: Data showed numerical and frequent structural changes in different number of chromosomes. For example gain in chromosomes number 1, 15, 17 and loss in 1, 7, 15, and also structural changes like deletion was seen in chromosomes number 1, 4, 8, 10, 15, 17, and addition in chromosome number 15. Discussion: It is predicted that CST6، PRKCDBP، PTCH1، DKK3، ، BRMS1، CDKN1C، CD81، DMP1، CDKN2B ، EEF1A1 ، HRAS، CASP2، KLF4 probably cause skin cancer.
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/07/11

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