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:: Volume 12, Number 2 (9-2009) ::
amuj 2009, 12(2): 73-87 Back to browse issues page
Determination of chromosomal changes in DMBA-induced skin cancer in SD rat strains
Mohammad ali Shariat zadeh , Ahmad Hamta, Malek Solimani, Zahra Rasoli
Associat professor
Abstract:   (11215 Views)
Background: Skin cancer is one of the most important cancers in the world. This cancer is more common in men than women. We survey chromosomal changes in DMBA-induced skin cancer in SD rat strains. Methods and Materials: In this fundamental study, 20 SD rat strains were randomly divided into case and contal group. DMBA (2.5 mg) was injected to SD rat strains subcutaneously therefore skin cancer model for studies was created. Tumors became subjects for cell culture and metaphase chromosomal were prepared. Finally G-banding were stained. We have also transmitted genomic information from rat to human using suitable databases and Gene were determined. Results: Data showed numerical and frequent structural changes in different number of chromosomes. For example gain in chromosomes number 1, 15, 17 and loss in 1, 7, 15, and also structural changes like deletion was seen in chromosomes number 1, 4, 8, 10, 15, 17, and addition in chromosome number 15. Discussion: It is predicted that CST6، PRKCDBP، PTCH1، DKK3، ، BRMS1، CDKN1C، CD81، DMP1، CDKN2B ، EEF1A1 ، HRAS، CASP2، KLF4 probably cause skin cancer.
Keywords: DMBA, Skin Cancer, SD Rat Strain
Full-Text [PDF 2055 kb]   (2601 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/07/11
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Shariat zadeh M A, Hamta A, Solimani M, Rasoli Z. Determination of chromosomal changes in DMBA-induced skin cancer in SD rat strains. amuj. 2009; 12 (2) :73-87
URL: http://amuj.arakmu.ac.ir/article-1-386-en.html
Volume 12, Number 2 (9-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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