Volume 18, Issue 5 (8-2015)                   J Arak Uni Med Sci 2015, 18(5): 33-48 | Back to browse issues page

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Jahani S, Salehi M, Shakiba A, Moradipour A, Forouzandeh F. Production and Study of Antioxidant and Antibacterial Activities of Gelatin Nano-Capsules Containing Ferula Assa-Foetida Essential Oil. J Arak Uni Med Sci. 2015; 18 (5) :33-48
URL: http://amuj.arakmu.ac.ir/article-1-3462-en.html
MSc, Institute of Biotechnology, University of Shiraz, Shiraz, Iran , amin_shakiba01@yahoo.com
Abstract:   (3247 Views)

Background:  Ferula assa-foetida is one of the common medicines that was used as antiseptic with a view to traditional uses, it can be used as a safe and effective drug to treat diseases particularly resistant bacterial infections. This study aims to product gelatin nano- capsules containing Ferula assa-foetida essential oil and investigate their antioxidant and antibacterial activities.

Materials and Methods: This experimental study was performed on gelatin nano-capsules containing Ferula assa-foetida essential oil (FAO) (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer and glutaraldehyde as cross-linker. The morphology, antioxidant and antibacterial activities and operation of the nano-capsules were assessed according to American Standards by Scanning Electron Microscopy, ABTS, and microbiological tests.

Results: Gelatin nano-capsules exhibited low antioxidant and antibacterial activities while gelatin nano-capsules incorporated with FAO exhibited excellent antioxidant and antibacterial. The highest rates of these effects were seen merged with 8% of FAO.

Conclusion: Gelatin nano-capsules merged with FAO have excellent physical form, as well as they are an appropriate antioxidant and antibacterial that have been considered to produce antoxidant and antibacterial drugs.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2015/01/27 | Accepted: 2015/04/15 | Published: 2015/07/22

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