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:: Volume 12, Issue 4 (2-2010) ::
AMUJ 2010, 12(4): 36-43 Back to browse issues page
The effects of maternal diabetes on brain lateral ventricles in newborn rats
Маryam Tehranipour , Jina Khayyatzade , Zahra Ghorbani
student , Ghorbany_z50@yahoo.com
Abstract:   (11682 Views)
Background: Maternal diabetes is associated with an increased risk of several complications in the offspring, such as the growth of congenital disturbances and malformations. In the present study, we examined the effects of maternal hyperglycemia on the volume of brain and lateral ventricle in newborn Wistar rats. Materials and Methods: In this experimental study, on the 7th day of pregnancy, hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg-1) and the animals in control group were given an equal volume of citrate buffer. After parturition on the first day of birth, a litter was randomly selected from each mother, their brains dissected and fixed in 10% formalin. Then they were sectioned with 7μm thickness and stained by H.E. Through the use of stereological techniques and systematic random sampling scheme, the volume of the brain and lateral ventricles were estimated. Results: Statistical analyses showed significant increases (p<0.05) in the volume of the brains and lateral ventricles in the experiment group in comparison to the control group. Conclusion: By affecting blood brain barrier permeability in newborn rats, maternal diabetes can generate a large amount of CSF. These effects can bring about brain disorders such as hydrocephalus.
Keywords: Hydrocephaly, Gestational diabetes mellitus, Lateral ventricles
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/05/18
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Tehranipour М, Khayyatzade J, Ghorbani Z. The effects of maternal diabetes on brain lateral ventricles in newborn rats. AMUJ. 2010; 12 (4) :36-43
URL: http://amuj.arakmu.ac.ir/article-1-325-en.html

Volume 12, Issue 4 (2-2010) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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