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:: Volume 17, Number 12 (3-2015) ::
amuj 2015, 17(12): 9-18 Back to browse issues page
Effects of Alpha-Lipoic Acid Supplementation on Blood Pressure and Some Inflammatory Factors in Women with Rheumatoid Arthritis
Bahram Pourghassem Gargari, Fereshteh Aliasghari, Sousan Kolahi, Mohammad Asghari jafarabadi, Elham Mirtaheri
MSc, Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , e.mirtaheri 2010@gmail.com
Abstract:   (3095 Views)

Background: Rheumatoid arthritis is an inflammatory disease. Hypertension could occur as a result of chronic inflammation in RA patients. Some evidence demonstrates anti-inflammatory effects of alpha-lipoic acid in inflammatory diseases. However, a limited number of studies have evaluated the effects of alpha-lipoic acid in rheumatoid arthritis. Therefore, the current study was designed to investigate the effects of alpha-lipoic acid supplementation on blood pressure and some inflammatory factors.

Materials and Methods: The present study was a randomized, double-blinded, placebo-controlled clinical trial in which 70 female patients aged 20–50 years were randomized to two groups to receive either alpha-lipoic acid (1200 mg/day) or placebo. The intervention duration was 8 weeks. Systolic and diastolic blood pressures were measured before and after the supplementation period. Also, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Statistical analysis was done using SPSS13 software.

Results: 65 RA patients completed the trial. Systolic and diastolic blood pressure in alpha-lipoic acid group was significantly decreased in comparison with placebo group (p<0.05). But, CRP and IL-6 serum levels did not indicate any significant within- and between group changes.

Conclusion: In the present study, alpha-lipoic acid supplementation resulted in significant blood pressure reduction in rheumatoid arthritis participants.

Keywords: Alpha-lipoic acid, Blood pressure, Inflammation, Rheumatoid arthritis
Full-Text [PDF 542 kb]   (837 Downloads)    
Type of Study: Original Atricle | Subject: Nutrition
Received: 2014/09/24 | Accepted: 2014/11/25 | Published: 2015/02/18
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Pourghassem Gargari B, Aliasghari F, Kolahi S, Asghari jafarabadi M, Mirtaheri E. Effects of Alpha-Lipoic Acid Supplementation on Blood Pressure and Some Inflammatory Factors in Women with Rheumatoid Arthritis. amuj. 2015; 17 (12) :9-18
URL: http://amuj.arakmu.ac.ir/article-1-3186-en.html
Volume 17, Number 12 (3-2015) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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