Volume 17, Issue 12 (3-2015)                   J Arak Uni Med Sci 2015, 17(12): 9-18 | Back to browse issues page

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Pourghassem Gargari B, Aliasghari F, Kolahi S, Asghari jafarabadi M, Mirtaheri E. Effects of Alpha-Lipoic Acid Supplementation on Blood Pressure and Some Inflammatory Factors in Women with Rheumatoid Arthritis. J Arak Uni Med Sci. 2015; 17 (12) :9-18
URL: http://amuj.arakmu.ac.ir/article-1-3186-en.html
MSc, Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , e.mirtaheri 2010@gmail.com
Abstract:   (3809 Views)

Background: Rheumatoid arthritis is an inflammatory disease. Hypertension could occur as a result of chronic inflammation in RA patients. Some evidence demonstrates anti-inflammatory effects of alpha-lipoic acid in inflammatory diseases. However, a limited number of studies have evaluated the effects of alpha-lipoic acid in rheumatoid arthritis. Therefore, the current study was designed to investigate the effects of alpha-lipoic acid supplementation on blood pressure and some inflammatory factors.

Materials and Methods: The present study was a randomized, double-blinded, placebo-controlled clinical trial in which 70 female patients aged 20–50 years were randomized to two groups to receive either alpha-lipoic acid (1200 mg/day) or placebo. The intervention duration was 8 weeks. Systolic and diastolic blood pressures were measured before and after the supplementation period. Also, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Statistical analysis was done using SPSS13 software.

Results: 65 RA patients completed the trial. Systolic and diastolic blood pressure in alpha-lipoic acid group was significantly decreased in comparison with placebo group (p<0.05). But, CRP and IL-6 serum levels did not indicate any significant within- and between group changes.

Conclusion: In the present study, alpha-lipoic acid supplementation resulted in significant blood pressure reduction in rheumatoid arthritis participants.

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Type of Study: Original Atricle | Subject: Nutrition
Received: 2014/09/24 | Accepted: 2014/11/25 | Published: 2015/02/18

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