Volume 18, Issue 2 (5-2015)                   J Arak Uni Med Sci 2015, 18(2): 10-16 | Back to browse issues page

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Tajbakhsh F, Mashayekhi F, Salehi Z, Saidi Saedi H, Yousefi M. The Association of ApE1 Gene Asp148Glu Polymorphism and Breast Cancer Risk in Guilan Population. J Arak Uni Med Sci. 2015; 18 (2) :10-16
URL: http://amuj.arakmu.ac.ir/article-1-3184-en.html
Professor, Department of biology, University of Guilan, Rasht, Iran , mashayekhi @guilan.ac.ir
Abstract:   (4761 Views)

Background: Breast cancer is the most common cancer and one of the main causes of cancer-related death all over the world that has become a major public health concern. Human apurinic/apyrimidinic endonuclease (ApE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. Single- nucleotide polymorphism T>G found in exon 5 led to substitution of Asp>Glu at codon 148 (Asp148Glu). In this case-control study, we aimed to evaluate the association of this polymorphism on the risk of breast cancer in Guilan population.

Materials and Methods: To study gene polymorphism APE1 (Case- Control), blood samples were collected from 75 patients diagnosed with breast cancer and 75 control subjects, and genotyped by allele-specific PCR (AS-PCR). To estimate the association between genotype and allele frequencies in cases and controls, Chi-Square analysis was used.

Results: Analysis revealed no significant differences were found in genotype and allele distributions of ApE1 Asp148Glu polymorphism between breast cancer patients and controls (p=0.1, p=0.6 respectively) in this population.

Conclusion: Data from this study indicated no significant association between the Asp148Glu polymorphism and breast cancer risk (p=0.1). Further study is needed to clarify the impact of Asp148Glu polymorphism on the breast cancer.

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Type of Study: Original Atricle | Subject: Health
Received: 2014/09/23 | Accepted: 2014/12/20 | Published: 2015/04/19

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