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:: Volume 12, Number 2 (9-2009) ::
amuj 2009, 12(2): 117-124 Back to browse issues page
Effect of special periods of post-training REM sleep in memory formation of Rats
Ebrahim Nabaee , Fereshteh Motamedi, Mohammad Ali Shariat zade, Masoomeh Nabaee
MSc , E_nabaee@yahoo.com
Abstract:   (12037 Views)
Background: REM sleep has a role in memory processing. The period of post-learning, that REM sleep is higher than normal level and deprivation of REM sleep impairs memory, is called paradoxical sleep windows (PSW). Methods and Materials: In this experimental study, male N.M.RI rats were trained in a two-way shuttle avoidance task (100 trials/one sessions) then memory retention was tested in next week. In electrophysiology section, different sleep-memory factors were recorded in basal level and 1-4 hours after training. In behavioral section, animals that reached 70% learning criterion (learner group) were deprived of PS in the two periods of 1-4 hours and 5-8 hours after learning by Maze water technique. Results: The amount of REM sleep in group which gained 70% learning after 1-4 hours training, and group without it. In v.s of basic level, significantly increase (p0.01). Other factors were showed no significant difference between two groups before of training. In behavioral section those animals were deprived in 1-4 hr post-learning show significant memory impairment (p0.05). Conclusion: Paradoxical increased REM sleep is effective in memory consolidation after 1-4 hours training. This period can be consider as paradoxical sleep window.
Keywords: Paradoxical Sleep, Paradoxical Sleep Window, REM Sleep Deprivation, Rat, Memory
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/05/12
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Nabaee E, Motamedi F, Shariat zade M A, Nabaee M. Effect of special periods of post-training REM sleep in memory formation of Rats. amuj. 2009; 12 (2) :117-124
URL: http://amuj.arakmu.ac.ir/article-1-314-en.html
Volume 12, Number 2 (9-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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